Table 1 Model input parameters
Parameter | Value | Reference |
Mortality rates | % (95% CI) | Â |
Mortality rates at 2 weeks |  | [9] |
 1-week AmBd/5FC | 11.6 (5.7–17.5) |  |
 1-week AmBd/Flu | 32.4 (23.7–41.1) |  |
 2-week AmBd/5FC | 20.9 (13.4–28.3) |  |
 2-week AmBd/Flu (SC) | 21.9 (14.3–29.5) |  |
 Oral 5FC/Flu | 18.2 (13.2–23.3) |  |
Mortality rates at 10 weeks |  | [9] |
 1-week AmBd/5FC | 23.9 (16.2–32.1) |  |
 1-week AmBd/Flu | 48.6 (39.4–57.9) |  |
 2-week AmBd/5FC | 38.3 (29.4–47.2) |  |
 2-week AmBd/Flu (SC) | 41.2 (32.3–50.4) |  |
 Oral 5FC/Flu | 35.1 (28.9–41.3) |  |
Mortality rates at 6 months |  | [12] |
 1-week AmBd/5FC | 27.5 (16.3–44.1) |  |
 1-week AmBd/Flu | 55.6 (40.4–72.0) |  |
 2-week AmBd/5FC | 45.9 (31.6–63.1) |  |
 2-week AmBd/Flu (SC) | 47.2 (32.6–64.5) |  |
 Oral 5FC/Flu | 36.0 (26.3–47.9) |  |
Mortality rates at 12 months |  | [12] |
 1-week AmBd/5FC | 27.5 (16.3–44.1) |  |
 1-week AmBd/Flu | 61.1 (45.8–76.7) |  |
 2-week AmBd/5FC | 45.9 (31.6–63.1) |  |
 2-week AmBd/Flu (SC) | 50.0 (35.1–67.1) |  |
 Oral 5FC/Flu | 44.0 (33.7–55.9) |  |
Parameter | Basecase (range) | Â |
Mortality rate per annum (year 2 onwards) | 0.65% (0.57–0.72) | [15] |
Utilities | ||
 Well with HIV | 0.95 (0.8–0.98) | [16] (a) |
 Ill with CM (induction) | 0.5 (0.43–0.58) | [16] (a) |
 Well with CM (maintenance) | 0.8 (0.68–0.92) | [16] (a) |
Length of stay (LOS) (days) | 17 (7–10) | [9] (b) |
Patient weight (kg) | 60 (45–75) | (c) |
Medicine costs (per dose) | USD | Â |
 Amphotericin B Deoxycholate (50 mg) | 0.63 | [17] |
 Fluconazole (200 mg) | 0.13 | [17] |
 Flucytosine (500 mg) | 34.02 | (d) |
 Saline 0.9% 1 l | 0.62 | [17] |
 Potassium chloride inj (15% in 10 ml) | 0.13 | [17] |
 Potassium tablets 600 mg | 0.08 | [17] |
 Magnesium tablets 250 mg | 0.02 | [17] |
 Flucloxacillin (50 mg) | 0.04 | [17] |
 Ceftriaxone 1 g vial | 0.44 | [17] |
 Ampicillin 500 mg vial | 12.14 | [17] |
 Ciprofloxacin 400 mg vial | 2.76 | [17] |
ART first line total cost per year | 251 | [18] |
Infusion fee per day | 15.25 (0–113.6) | [19] (e) |
Hospital cost per day | 85.06 (73.41–189.39) | [19] (f) |
Laboratory monitoring | ||
 Serum potassium | 2.17 | [20] |
 Serum creatinine | 2.17 | [20] |
 Serum magnesium | 2.17 | [20] |
 Haemoglobin | 4.38 | [20] |
 Full blood count | 4.14 | [20] |
 Blood draw | 2.79 | [20] |
Lumbar puncture | ||
 Diagnostic | 60.75 | |
 Therapeutic | 46.02 | |
 Blood transfusion | 170 | [21] |
Discount rate | 5% (0–10%) | [14] |