Comorbidity | Index admission LOS (n = 140,094) | Index hospital admission cost (n = 104,609) | ||||
n (%) | Index LOS (mean, 95% CI) | Adjusted ORa,b (95% CI) | IRRc,d (95% CI) | Coste (mean, 95% CI) | Adjusted beta coefficienta (95% CI) | |
HIV/AIDS | 54 (0.0) | 11.1 (5.0–17.1) | 1.05 (0.53–2.11) | 1.11 (0.85–1.44) | 13,064.9 (6672.5–19,457.4) | 0.40 (0.12–0.68) |
Alcohol dependence | 6425 (4.6) | 7.1 (6.6–7.6) | 1.38 (1.29–1.48) | 1.17 (1.14–1.20) | 8927.3 (8464.9–9389.7) | 0.20 (0.17–0.23) |
Drug dependence | 1496 (1.1) | 8.1 (7.0–9.2) | 2.34 (2.01–2.72) | 1.56 (1.49–1.64) | 11,228.8 (10,195.1–12,262.4) | 0.47 (0.41–0.52) |
Any malignancy | 706 (0.5) | 21.2 (19.5–22.8) | 6.15 (3.09–12.22) | 1.56 (1.40–1.73) | 23,110.8 (21,132.8–25,088.8) | 0.65 (0.52–0.78) |
Blood loss anemia | 170 (0.1) | 24.7 (21.0–28.5) | 5.56 (1.71–18.08) | 1.40 (1.20–1.63) | 29,192.2 (24,390.9–33,993.4) | 0.61 (0.44–0.77) |
Cardiac arrhythmias | 3775 (2.7) | 19.0 (18.2–19.8) | 2.44 (2.14–2.79) | 1.32 (1.28–1.36) | 20,572.8 (19,549.5–21,596.0) | 0.48 (0.44–0.51) |
Cerebrovascular disease | 602 (0.4) | 24.2 (21.0–27.5) | 1.74 (1.08–2.79) | 1.18 (1.08–1.29) | 23,691.7 (21,388.4–25,995.0) | 0.19 (0.08–0.30) |
Chronic pulmonary disease | 1302 (0.9) | 22.8 (21.3–24.2) | 6.24 (4.22–9.22) | 1.46 (1.38–1.54) | 26,770.7 (24,643.6–28,897.8) | 0.57 (0.51–0.64) |
Coagulopathy | 1133 (0.8) | 18.9 (17.1–20.8) | 3.73 (2.79–4.98) | 1.43 (1.35–1.51) | 22,255.5 (19,748.4–24,762.6) | 0.49 (0.43–0.56) |
Congestive heart failure | 1257 (0.9) | 24.8 (23.5–26.2) | 6.84 (4.14–11.30) | 1.27 (1.20–1.34) | 26,944.0 (25,240.2–28,647.9) | 0.38 (0.31–0.44) |
Deficiency anemias | 578 (0.4) | 24.1 (21.9–26.2) | 8.56 (4.65–15.75) | 1.62 (1.50–1.76) | 22,380.0 (20,429.5–24,330.5) | 0.66 (0.56–0.75) |
Dementia | 2889 (2.1) | 16.2 (15.5–16.9) | 1.99 (1.70–2.34) | 1.05 (1.02–1.09) | 16,671.0 (15,968.2–17,373.8) | 0.16 (0.11–0.20) |
Depression | 2966 (2.1) | 9.2 (8.6–9.9) | 3.25 (2.89–3.65) | 1.93 (1.86–2.01) | 10,987.7 (10,125.5–11,849.9) | 0.63 (0.59–0.67) |
Diabetes with chronic complications | 4243 (3.0) | 18.6 (17.9–19.4) | 1.42 (1.26–1.60) | 1.27 (1.23–1.31) | 19,104.6 (18,238.8–19,970.5) | 0.26 (0.22–0.30) |
Diabetes without complications | 8969 (6.4) | 12.0 (11.5–12.4) | 1.20 (1.13–1.28) | 1.12 (1.09–1.14) | 12,223.6 (11,710.2–12,737.0) | 0.10 (0.07–0.12) |
Hemiplegia/paraplegia | 538 (0.4) | 25.7 (22.3–29.1) | 4.14 (2.51–6.83) | 1.61 (1.47–1.78) | 25,975.1 (22,961.5–28,988.6) | 0.60 (0.49–0.71) |
Hypertension complicated | 54 (0.0) | 25.4 (17.6–33.1) | O | 1.41 (1.09–1.82) | 28,041.4 (20,243.3–35,839.6) | 0.48 (0.20–0.76) |
Hypertension uncomplicated | 4510 (3.2) | 21.5 (20.7–22.2) | 2.45 (2.11–2.84) | 1.26 (1.22–1.30) | 22,582.5 (21,702.8–23,462.3) | 0.41 (0.37–0.45) |
Hypothyroidism | 152 (0.1) | 21.3 (17.3–25.3) | 21.00 (2.89–152.81) | 1.72 (1.48–1.99) | 22,116.8 (17,862.1–26,371.5) | 0.56 (0.38–0.74) |
Metastatic solid tumor | 380 (0.3) | 20.4 (18.3–22.5) | 1.39 (0.54–3.57) | 1.32 (1.15–1.52) | 22,163.4 (19,616.7–24,710.1) | 0.16 (−0.02–0.33) |
Mild liver disease | 1167 (0.8) | 10.5 (9.4–11.7) | 1.63 (1.37–1.93) | 1.27 (1.20–1.34) | 13,166.4 (11,933.4–14,399.4) | 0.31 (0.25–0.38) |
Moderate or severe liver disease | 116 (0.1) | 20.2 (15.1–25.3) | 20.59 (2.83–149.95) | 1.83 (1.54–2.19) | 25,608.6 (19,508.8–31,708.4) | 0.81 (0.60–1.01) |
Myocardial infarction | 248 (0.2) | 23.9 (21.0–26.8) | 2.78 (1.11–6.96) | 0.96 (0.85–1.09) | 27,805.7 (24,266.1–31,345.4) | 0.24 (0.10–0.38) |
Obesity | 229 (0.2) | 27.9 (22.6–33.2) | 4.39 (2.26–8.54) | 2.10 (1.85–2.39) | 29,539.4 (23,323.0–35,755.7) | 0.80 (0.65–0.95) |
Peptic ulcer disease | 84 (0.1) | 20.3 (14.4–26.2) | 1.96 (0.90–4.29) | 1.55 (1.25–1.92) | 23,885.5 (15,681.1–32,089.8) | 0.66 (0.40–0.91) |
Peripheral vascular disease | 702 (0.5) | 17.2 (15.4–19.1) | 3.10 (2.34–4.11) | 1.88 (1.76–2.02) | 19,444.2 (17,341.6–21,546.9) | 0.75 (0.66–0.83) |
Psychoses | 568 (0.4) | 20.2 (17.2–23.1) | 5.54 (3.96–7.74) | 3.14 (2.91–3.39) | 22,213.8 (19,103.3–25,324.3) | 1.04 (0.95–1.13) |
Pulmonary circulation disorders | 133 (0.1) | 33.6 (28.0–39.2) | 9.06 (1.24–66.43) | 1.81 (1.52–2.16) | 39,206.1 (30,612.7–47,799.5) | 0.79 (0.58–0.99) |
Renal disease including renal failure | 3402 (2.4) | 22.3 (21.5–23.2) | 1.54 (1.29–1.84) | 1.16 (1.11–1.20) | 22,865.3 (21,879.6–23,851.0) | 0.20 (0.15–0.24) |
Rheumatic disease including some other connective tissue disorders | 177 (0.1) | 25.4 (21.7–29.1) | 31.75 (4.41–228.88) | 1.93 (1.66–2.23) | 27,277.3 (22,034.9–32,519.7) | 0.84 (0.66–1.02) |
Valvular disease | 326 (0.2) | 27.9 (24.8–31.0) | 5.23 (2.27–12.02) | 1.36 (1.22–1.52) | 28,473.9 (24,958.1–31,989.7) | 0.41 (0.28–0.55) |
Comorbidity | Readmissions (n = 136,670) | |||||
n (%) | All-cause 30-day readmission | Non-planned 30-day readmission | ||||
beta coefficienta (95% CI) | % with condition that had the outcome | Adjusted ORa (95% CI) | % with condition that had the outcome | Adjusted ORa (95% CI) | ||
HIV/AIDS | 53 (0.0) | 20.8 | 1.50 (0.76–2.95) | 20.8 | 2.57 (1.31–5.06) | |
Alcohol dependence | 6119 (4.5) | 15.3 | 1.22 (1.13–1.31) | 11.4 | 1.34 (1.23–1.46) | |
Drug dependence | 1350 (1.0) | 16.0 | 1.27 (1.09–1.48) | 12.9 | 1.45 (1.23–1.72) | |
Any malignancy | 561 (0.4) | 44.0 | 3.45 (2.71–4.40) | 20.7 | 1.64 (1.21–2.23) | |
Blood loss anemia | 159 (0.1) | 22.0 | 1.20 (0.81–1.77) | 14.5 | 1.09 (0.69–1.72) | |
Cardiac arrhythmias | 3480 (2.5) | 18.2 | 1.06 (0.97–1.16) | 13.4 | 1.10 (0.99–1.22) | |
Cerebrovascular disease | 545 (0.4) | 19.1 | 1.08 (0.83–1.40) | 14.3 | 1.08 (0.81–1.45) | |
Chronic pulmonary disease | 1176 (0.9) | 23.0 | 1.40 (1.21–1.61) | 18.2 | 1.60 (1.37–1.86) | |
Coagulopathy | 1032 (0.8) | 23.5 | 1.43 (1.23–1.66) | 18.1 | 1.53 (1.30–1.81) | |
Congestive heart failure | 1048 (0.8) | 24.0 | 1.20 (1.03–1.40) | 19.3 | 1.34 (1.14–1.58) | |
Deficiency anemias | 550 (0.4) | 24.0 | 1.28 (1.05–1.58) | 18.7 | 1.42 (1.13–1.77) | |
Dementia | 2663 (1.9) | 15.5 | 0.89 (0.79–0.99) | 13.3 | 1.12 (1.00–1.26) | |
Depression | 2877 (2.1) | 18.8 | 1.36 (1.23–1.52) | 11.8 | 1.14 (1.01–1.30) | |
Diabetes with chronic complications | 3978 (2.9) | 23.9 | 1.24 (1.13–1.35) | 16.9 | 1.29 (1.16–1.43) | |
Diabetes without complications | 8655 (6.3) | 17.2 | 1.18 (1.11–1.25) | 12.1 | 1.21 (1.13–1.30) | |
Hemiplegia/paraplegia | 494 (0.4) | 18.6 | 1.17 (0.89–1.54) | 13.8 | 1.20 (0.88–1.63) | |
Hypertension complicated | 42 (0.0) | 40.5 | 1.89 (1.01–3.55) | 21.4 | 1.30 (0.61–2.76) | |
Hypertension uncomplicated | 4165 (3.0) | 22.0 | 1.05 (0.96–1.15) | 16.0 | 1.13 (1.02–1.25) | |
Hypothyroidism | 148 (0.1) | 17.6 | 0.93 (0.61–1.44) | 14.9 | 1.15 (0.73–1.83) | |
Metastatic solid tumor | 287 (0.2) | 46.3 | 1.37 (0.98–1.92) | 22.6 | 1.50 (0.99–2.26) | |
Mild liver disease | 1055 (0.8) | 21.5 | 1.65 (1.41–1.93) | 17.3 | 1.84 (1.55–2.18) | |
Moderate or severe liver disease | 90 (0.1) | 30.0 | 1.45 (0.90–2.32) | 23.3 | 1.41 (0.84–2.36) | |
Myocardial infarction | 197 (0.1) | 21.8 | 1.08 (0.76–1.53) | 18.3 | 1.21 (0.83–1.76) | |
Obesity | 219 (0.2) | 20.1 | 1.34 (0.95–1.89) | 16.4 | 1.59 (1.10–2.31) | |
Peptic ulcer disease | 70 (0.1) | 17.1 | 0.96 (0.51–1.82) | 7.1 | 0.54 (0.21–1.36) | |
Peripheral vascular disease | 673 (0.5) | 19.5 | 1.37 (1.12–1.67) | 12.9 | 1.30 (1.03–1.64) | |
Psychoses | 536 (0.4) | 21.6 | 1.64 (1.33–2.03) | 15.1 | 1.56 (1.22–1.99) | |
Pulmonary circulation disorders | 120 (0.1) | 20.8 | 0.94 (0.59–1.49) | 15.0 | 0.89 (0.53–1.51) | |
Renal disease including renal failure | 3042 (2.2) | 30.0 | 1.92 (1.73–2.12) | 20.2 | 1.56 (1.39–1.76) | |
Rheumatic disease including some other connective tissue disorders | 168 (0.1) | 22.0 | 1.39 (0.95–2.02) | 15.5 | 1.46 (0.95–2.24) | |
Valvular disease | 290 (0.2) | 19.3 | 1.03 (0.76–1.39) | 14.5 | 1.08 (0.77–1.51) |