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Table 1 Base-case model variables and ranges used in a sensitivity analysis

From: Cost‐effectiveness analysis of dabigatran, rivaroxaban and warfarin in the prevention of stroke in patients with atrial fibrillation in China

Variable Value Range Reference
Probabilities
 Probability of ischemic stroke caused by different drugs
  Warfarin 0.04 0.023–0.0453 [18,19,20]
  Rivaroxaban 0.0193 NA [19]
  Dabigatran110mg 0.0183 0.0167–0.0189 [18, 19]
  Dabigatran150mg 0.0137 NA [20]
 Probability of ischemic stroke outcome by severity
  Light 0.091 0.091–0.133 [21]
  Moderate 0.425 0.348–0.425 [21]
  Severe 0.402 0.402–0.417 [21]
  Die(in 30day) 0.082 0.082–0.101 [21]
  Probability of ICH caused by different drugs    
  Warfarin 0.0121 0.0057–0.0294 [18, 19, 22]
  Rivaroxaban 0.00257 0.0021–0.0033 [19, 22]
  Dabigatran110mg 0.00359 0.0028–0.0039 [18, 19]
  Dabigatran150mg 0.0027 NA [18]
 Probability of ICH outcome by severity
  Light 0.12 NA [21, 23]
  Moderate 0.27 NA [21, 23]
  Severe 0.43 NA [21, 23]
  Die 0.18 NA [21, 23]
 Probability of ECH caused by different drugs
  Warfarin 0.027 NA [24]
  Rivaroxaban 0.03 NA [23]
  Dabigatran110mg 0.007 NA [24]
  Dabigatran150mg 0.0217 NA [23]
 Probability of ECH outcome by severity
  Die 0.0147 0.01–0.04 [21]
  Probability of MI caused by different drugs    
  Warfarin 0.0098 NA [21]
  Rivaroxaban 0.0098 NA [21]
  Dabigatran110mg 0.0072 NA [18]
  Dabigatran150mg 0.0074 NA [18]
  Probability of MI outcome by severity
  Death 0.166 0.158–0.174 [21, 25]
 All-cause mortality by different drugs
  Warfarin 0.026 0.0258–0.0261 [18, 22]
  Rivaroxaban 0.0164 NA [22]
  Dabigatran110mg 0.0333 NA [18]
  Dabigatran150mg 0.0219 NA [18]
 Cost
  Price (specification/$)   Range of daily dose  
  warfarin 3 mg/0.07 1.5 mg-6 mg/d  
  Rivaroxaban 20 mg/4.87 15–20 mg qd  
  Dabigatran110mg 110 mg/2.34 110–150 mg bid  
  Dabigatran150mg 150 mg/3.01 110–150 mg bid  
  Cost of examination and service 10.77 NA  
  Frequency about examination/Annual    
  warfarin 21 NA [26]
 Rivaroxaban and Dabigatran 1 NA  
 Total cost $(drug and examination)
  Warfarin 253.30 239.70-280.51  
  Rivaroxaban 1787.00 1435.86-2844.52  
  Dabigatran110mg 1718.21 1711.17-2206.93  
  Dabigatran150mg 2206.93 1711.17-2206.93  
 Event
  Stroke 1351.20 851.36-2681.69  
  ICH 2605.43 1935.86-3862.05  
  ECH 1216.72 867.23-2516.68  
  MI 3875.18 1805.02-5529.89  
Health utility values in each state
  Light 0.76 0.7–0.9 [27]
  Moderate 0.39 0.1–0.5 [27]
  Severe 0.16 0.0-0.32 [27]
  ICH 0.8 0.79–0.84 [28]
  ECH 0.8 0.79–0.84 [28]
  MI 0.84 0.67–0.96 [29]
  1. ICH Intracranial hemorrhage; ECH Extracranial hemorrhage; MI Myocardial infarction