Table 5 Economic evaluation based on CHEERS criteria (statistical analysis and results)
Study ID | Statistical analysis of cost data | Statistical analysis for missing data | Incremental economic analysis reported | Sensitivity analysis | Difference in outcome | Difference in costs | Difference in outcome and costs |
|---|---|---|---|---|---|---|---|
Skouen 2002 [19] Norway | Not reported, only mean difference in outcome evaluated by ANOVA. RR and 95% CI for the effect of intervention versus comparator on outcome. | Not reported | productivity gain = NoK 7,858,100 - cost, the net productivity gain = 240,900 | Not performed | Yes | Not reported | No |
Rivero-Arias [22] 2005 UK | Arithmetic mean for cost and outcomes | Intention to treat and multiple imputation (variance correction) | Bootstrapping (1000 replications) | Yes | No | Yes | Yes |
Smeets 2009 [21] Netherland | student t test for change in outcomes, linear regression to adjust for baseline differences | Intention to treat analysis, missing data were replaced by mean score of cost and utility | Bootstrapping (1000 replications) | Yes | No | No | No |
Lambeek [20] 2010 Netherlands | Not reported | Intention to treat analysis, multiple imputation | Bootstrapping (5000 replications) | Yes | Yes | Yes | Yes |
Johnsen 2014 [18] Norway | Student t test for cost and utilities | Intention to treat analysis, multiple imputation | Bootstrapping (10,000 replications) | Yes | Yes | Yes | Yes |