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Table 1 Definitions of thyroid disorders based on SHIP-data and claims data

From: Frequency of thyroid function tests and examinations in participants of a population-based study

Thyroid disordersSubgroupsClinical examination (SHIP)aBilling diagnosisb
laboratory value and measurementsmedication (ATC codes)ICD-10 GM
HyperthyroidismsubclinicalTSH < 0.49 mIU/l
fT4 10.10–16.50 pmol/l
noE05.- hyperthyroidism
clinical manifestation, untreatedTSH < 0.49 mIU/l
fT4 > 16.50 pmol/l
no
treatednot consideredH03BB01 carbimazol
H03BB02 thiamazol
iatrogenicTSH < 0.49 mIU/lH03AA.- levothyroxin /combinations
HypothyroidismsubclinicalTSH > 3.29 mIU/l
fT4 10.10–16.50 pmol/l
noE02.- subclinical Iodine deficiency hypothyroidism
E03.- other hypothyroidism
clinical manifestation, untreatedTSH > 3.29 mIU/l
fT4 < 10.10
no
treatedTSH 0.49–3.29 mIU/lH03AA.- levothyroxin / combination
potentially undertreatedTSH > 3.29 mIU/lH03AA.- levothyroxin /combination
Thyroiditis TPO-antibody
> 200 IU/ml
 E06.- thyroiditis
Goitre thyroid volume
men > 25 ml
women > 18 ml
 E01.0 diffuse goitre due to iodine deficiency
E01.1 multinodular goitre due to iodine deficiency
E01.2 goitre due to iodine deficiency
E03.0 congenital hypothyroidism with diffuse goitre
E04.0 nontoxic diffuse goitre
E04.2 nontoxic multinodular goitre
E04.8 other nontoxic goitre
E04.9 other not specified nontoxic goitre
E05.0 hyperthyroidism with diffuse goitre
E05.2 hyperthyroidism with toxic multinodular goitre
E07.1 dyshormonogenetic goitre
Nodular goitre thyroid volume
men > 25 ml
women > 18 ml and at least one nodule
 E01.1 multinodular goitre due to iodine deficiency
E04.2 nontoxic multinodular goitre E05.2 hyperthyroidism with toxic multinodular goitre
Diffuse goitre thyroid volume
men > 25 ml
women > 18 ml and no nodule
 E01.0 diffuse goitre due to iodine deficiency
E03.0 congenital hypothyroidism with diffuse goitre
E04.0 nontoxic diffuse goitre
E05.0 hyperthyroidism with diffuse goitre
Thyroid nodule ultrasound examination nodule size < 1 cm or > = 1 cm E01.1 multinodular goitre due to iodine deficiency
E04.1 nontoxic thyroid nodule
E04.2 nontoxic multinodular goitre E05.1 hyperthyroidism with toxic solitary thyroid nodule
E05.2 hyperthyroidism with toxic multinodular goitre
D34 benign neoplasm of the thyroid
Thyroid cancer self-reported (interview) C73 malignancy neoplasm of the thyroid
D09.3 carcinoma in situ thyroid and other endocrine gland
  1. ATC-Codes Anatomical Therapeutic Chemical Classification, ICD-10 GM International Classification of Disease 10th Revision, German Modification, TSH Thyroid Stimulating Hormone, fT3 free triiodothyronine, fT4 free thyroxine, TPO-antibody Thyroid Peroxidase Antibody
  2. aat the time of SHIP-2 or SHIP-TREND examination
  3. bat least one relevant and confirmed ICD diagnosis coded as acute or permanent diagnosis in the billing data within 5 years prior to the SHIP-2/SHIP-TREND study entrance of the participant