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Table 2 Prevalence, adjusted odds ratio and weights from the (new) Swiss derivation sample and the van Walraven (VW) derivation sample [25]

From: Comparing Charlson and Elixhauser comorbidity indices with different weightings to predict in-hospital mortality: an analysis of national inpatient data

Elixhauser comorbidities Alive cohort (%) Mortality cohort (%) SMD Adjusted odds ratio (95% CI) Weights
  Swiss derivation sample VWa Swiss VWa Swiss
bDerivation group 2,975,887 (97.7) 71,449 (2.3)      
Congestive heart failure 163,685 (5.5) 16,333 (22.9) 0.514 1.96 (1.85–2.07) 3.07 (3.00–3.14) 7 13
Cardiac arrhythmias 341,280 (11.5) 20,754 (29.0) 0.448 1.71 (1.62–1.80) 1.69 (1.66–1.73) 5 6
Valvular disease 117,450 (3.9) 6568 (9.2) 0.213 0.91 (0.82–0.99) 0.92 (0.89–0.95) -1 -1
Pulmonary circulation disorders 53,292 (1.8) 4813 (6.7) 0.247 1.48 (1.34–1.62) 1.62 (1.57–1.68) 4 6
Peripheral vascular disorders 141,051 (4.7) 6912 (9.7) 0.192 1.26 (1.17–1.36) 1.27 (1.24–1.31) 2 3
Hypertension (uncomplicated) 676,609 (22.7) 15,692 (22.0) 0.019 0.69 (0.68–0.70) 0 −4
Hypertension (complicated) 218,656 (7.3) 11,003 (15.4) 0.256 0.79 (0.77–0.81) 0 −3
Paralysis 61,546 (2.1) 5153 (7.2) 0.246 1.93 (1.75–2.12) 2.60 (2.52–2.69) 7 11
Other neurological disorders 120,045 (4.0) 8011 (11.2) 0.273 1.83 (1.70–1.96) 2.45 (2.39–2.52) 6 10
Chronic pulmonary disease 170,770 (5.7) 8269 (11.6) 0.209 1.36 (1.29–1.44) 1.31 (1.27–1.34) 3 3
Diabetes, uncomplicated 245,817 (8.3) 9059 (12.7) 0.145 1.09 (1.06–1.11) 0 1
Diabetes, complicated 66,161 (2.2) 2763 (3.9) 0.096 0.89 (0.86–0.93) 0 −1
Hypothyroidism 126,062 (4.2) 3454 (4.8) 0.029 0.76 (0.74–0.79) 0 −3
Renal failure 289,047 (9.7) 20,526 (28.7) 0.497 1.63 (1.54–1.73) 2.06 (2.02–2.11) 5 8
Liver disease 49,916 (1.7) 5822 (8.1) 0.303 2.97 (2.73–3.22) 3.83 (3.7–3.97) 11 16
Peptic ulcer disease, excluding bleeding 5808 (0.2) 258 (0.4) 0.032 0 0
AIDS/HIV 2300 (0.1) 85 (0.1) 0.013 0 0
Lymphoma 25,049 (0.8) 1759 (2.5) 0.127 2.55 (2.31–2.81) 2.19 (2.07–2.31) 9 9
Metastatic cancer 119,667 (4.0) 18,907 (26.5) 0.657 3.30 (3.10–3.52) 4.09 (3.98–4.21) 12 17
Solid tumour without metastasis 268,298 (9.0) 24,046 (33.7) 0.631 1.47 (1.39–1.56) 2.36 (2.3–2.42) 4 10
Rheumatoid arthritis/collagen vascular diseases 47,305 (1.6) 1254 (1.8) 0.013 0.91 (0.86–0.97) 0 −1
Coagulopathy 90,551 (3.0) 9528 (13.3) 0.382 1.30 (1.22–1.40) 2.12 (2.07–2.18) 3 9
Obesity 68,155 (2.3) 1011 (1.4) 0.065 0.64 (0.53–0.77) 0.59 (0.56–0.63) −4 −6
Weight loss 98,545 (3.3) 9527 (13.3) 0.369 1.85 (1.67–2.04) 1.67 (1.63–1.71) 6 6
Fluid and electrolyte disorders 257,618 (8.7) 17,440 (24.4) 0.434 1.61 (1.53–1.69) 1.58 (1.55–1.61) 5 5
Blood loss anaemia 19,759 (0.7) 685 (1.0) 0.033 0.81 (0.70–0.93) 0.66 (0.60–0.71) −2 −5
Deficiency anaemia 72,290 (2.4) 1886 (2.6) 0.013 0.80 (0.71–0.90) 0.54 (0.51–0.56) −2 −7
Alcohol abuse 96,708 (3.2) 3086 (4.3) 0.056 0.75 (0.72–0.78) 0 −3
Drug abuse 38,044 (1.3) 583 (0.8) 0.045 0.50 (0.42–0.60) 0.67 (0.61–0.73) −7 −5
Psychoses 29,598 (1.0) 404 (0.6) 0.049 0.72 (0.65–0.79) 0 −4
Depression 173,898 (5.8) 3715 (5.2) 0.028 0.73 (0.67–0.80) 0.73 (0.70–0.75) −3 −3
  1. The total cohort percentages can exceed 100%, as each admission contributes to one or more comorbidities. Swiss weights are calculated by dividing the coefficient of each comorbidity by the coefficient in the model with the smallest absolute value (which is ‘diabetes uncomplicated’ with a coefficient of 0.084) and rounding to the nearest whole number
  2. Abbreviations: SMD standardized mean difference between alive and mortality cohort, VWa van Walraven, `–` excluded in the final model, bRow percentage