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Table 2 Prevalence, adjusted odds ratio and weights from the (new) Swiss derivation sample and the van Walraven (VW) derivation sample [25]

From: Comparing Charlson and Elixhauser comorbidity indices with different weightings to predict in-hospital mortality: an analysis of national inpatient data

Elixhauser comorbidities

Alive cohort (%)

Mortality cohort (%)

SMD

Adjusted odds ratio (95% CI)

Weights

 

Swiss derivation sample

VWa

Swiss

VWa

Swiss

bDerivation group

2,975,887 (97.7)

71,449 (2.3)

     

Congestive heart failure

163,685 (5.5)

16,333 (22.9)

0.514

1.96 (1.85–2.07)

3.07 (3.00–3.14)

7

13

Cardiac arrhythmias

341,280 (11.5)

20,754 (29.0)

0.448

1.71 (1.62–1.80)

1.69 (1.66–1.73)

5

6

Valvular disease

117,450 (3.9)

6568 (9.2)

0.213

0.91 (0.82–0.99)

0.92 (0.89–0.95)

-1

-1

Pulmonary circulation disorders

53,292 (1.8)

4813 (6.7)

0.247

1.48 (1.34–1.62)

1.62 (1.57–1.68)

4

6

Peripheral vascular disorders

141,051 (4.7)

6912 (9.7)

0.192

1.26 (1.17–1.36)

1.27 (1.24–1.31)

2

3

Hypertension (uncomplicated)

676,609 (22.7)

15,692 (22.0)

0.019

–

0.69 (0.68–0.70)

0

−4

Hypertension (complicated)

218,656 (7.3)

11,003 (15.4)

0.256

–

0.79 (0.77–0.81)

0

−3

Paralysis

61,546 (2.1)

5153 (7.2)

0.246

1.93 (1.75–2.12)

2.60 (2.52–2.69)

7

11

Other neurological disorders

120,045 (4.0)

8011 (11.2)

0.273

1.83 (1.70–1.96)

2.45 (2.39–2.52)

6

10

Chronic pulmonary disease

170,770 (5.7)

8269 (11.6)

0.209

1.36 (1.29–1.44)

1.31 (1.27–1.34)

3

3

Diabetes, uncomplicated

245,817 (8.3)

9059 (12.7)

0.145

–

1.09 (1.06–1.11)

0

1

Diabetes, complicated

66,161 (2.2)

2763 (3.9)

0.096

–

0.89 (0.86–0.93)

0

−1

Hypothyroidism

126,062 (4.2)

3454 (4.8)

0.029

–

0.76 (0.74–0.79)

0

−3

Renal failure

289,047 (9.7)

20,526 (28.7)

0.497

1.63 (1.54–1.73)

2.06 (2.02–2.11)

5

8

Liver disease

49,916 (1.7)

5822 (8.1)

0.303

2.97 (2.73–3.22)

3.83 (3.7–3.97)

11

16

Peptic ulcer disease, excluding bleeding

5808 (0.2)

258 (0.4)

0.032

–

–

0

0

AIDS/HIV

2300 (0.1)

85 (0.1)

0.013

–

–

0

0

Lymphoma

25,049 (0.8)

1759 (2.5)

0.127

2.55 (2.31–2.81)

2.19 (2.07–2.31)

9

9

Metastatic cancer

119,667 (4.0)

18,907 (26.5)

0.657

3.30 (3.10–3.52)

4.09 (3.98–4.21)

12

17

Solid tumour without metastasis

268,298 (9.0)

24,046 (33.7)

0.631

1.47 (1.39–1.56)

2.36 (2.3–2.42)

4

10

Rheumatoid arthritis/collagen vascular diseases

47,305 (1.6)

1254 (1.8)

0.013

–

0.91 (0.86–0.97)

0

−1

Coagulopathy

90,551 (3.0)

9528 (13.3)

0.382

1.30 (1.22–1.40)

2.12 (2.07–2.18)

3

9

Obesity

68,155 (2.3)

1011 (1.4)

0.065

0.64 (0.53–0.77)

0.59 (0.56–0.63)

−4

−6

Weight loss

98,545 (3.3)

9527 (13.3)

0.369

1.85 (1.67–2.04)

1.67 (1.63–1.71)

6

6

Fluid and electrolyte disorders

257,618 (8.7)

17,440 (24.4)

0.434

1.61 (1.53–1.69)

1.58 (1.55–1.61)

5

5

Blood loss anaemia

19,759 (0.7)

685 (1.0)

0.033

0.81 (0.70–0.93)

0.66 (0.60–0.71)

−2

−5

Deficiency anaemia

72,290 (2.4)

1886 (2.6)

0.013

0.80 (0.71–0.90)

0.54 (0.51–0.56)

−2

−7

Alcohol abuse

96,708 (3.2)

3086 (4.3)

0.056

–

0.75 (0.72–0.78)

0

−3

Drug abuse

38,044 (1.3)

583 (0.8)

0.045

0.50 (0.42–0.60)

0.67 (0.61–0.73)

−7

−5

Psychoses

29,598 (1.0)

404 (0.6)

0.049

–

0.72 (0.65–0.79)

0

−4

Depression

173,898 (5.8)

3715 (5.2)

0.028

0.73 (0.67–0.80)

0.73 (0.70–0.75)

−3

−3

  1. The total cohort percentages can exceed 100%, as each admission contributes to one or more comorbidities. Swiss weights are calculated by dividing the coefficient of each comorbidity by the coefficient in the model with the smallest absolute value (which is ‘diabetes uncomplicated’ with a coefficient of 0.084) and rounding to the nearest whole number
  2. Abbreviations: SMD standardized mean difference between alive and mortality cohort, VWa van Walraven, `–` excluded in the final model, bRow percentage