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Table 4 Clinically significant drug – drug interactions in prescriptions which were not detected by pharmacists

From: Nature of dispensing errors in selected hospitals providing free healthcare: a multi-center study in Sri Lanka

Interacting medicine pair Severity of interactiona Frequency (%)
Olanzapine, clonazepam Major 11 (27.5)
Clopidogrel, omeprazole Major 3 (7.5)
Amitriptyline, fluoxetine Major 3 (7.5)
Haloperidol, fluphenazine Major 3 (7.5)
Olanzapine, topiramate Major 3 (7.5)
Losartan, spironolactone Major 2 (5.0)
Haloperidol, promethazine Major 2 (5.0)
Haloperidol, lithium Major 2 (5.0)
Haloperidol, chlorpromazine Major 2 (5.0)
Enalapril, spironolactone Major 1 (2.5)
Fluoxetine, clopidogrel Major 1 (2.5)
Imipramine, haloperidol Major 1 (2.5)
Pioglitazone, clopidogrel Major 1 (2.5)
Sodium valproate, lamotrigine Major 1 (2.5)
Captopril, potassium chloride Major 1 (2.5)
Imipramine, fluoxetine Major 1 (2.5)
Enalapril, potassium chloride Major 1 (2.5)
Clonazepam, topiramate Major 1 (2.5)
Total   40
  1. aSeverity of interactions as denoted in the Drugs.com [25], online drug interaction checker