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Table 4 Consumption of diabetes medications in 2016 and 2017.

From: Impact of co-payment level increase of antidiabetic medications on glycaemic control: an interrupted time-series study among Finnish patients with type 2 diabetes

 

N of users (N of purchases)

Total consumption, DDDs

Purchases/patient (SD)

DDDs/patient/purchase (SD)

DDDs/patient/year (SD)

2016

2017

2016

2017

2016

2017

P value

2016

2017

P value

2016

2017

P value

All patients (n = 8143)

7116 (55,104)

7036 (58,212)

12,065

11,621

7.7 (7.5)

8.3 (8.2)

< 0.001

79.9 (61.3)

72.9 (59.4)

< 0.001

618.9 (487.8)

602.9 (475.6)

0.048

Patients alive on Jan 1, 2018 (n = 8025)

6793 (52,050)

6780 (56,764)

11,619

11,446

7.7 (7.4)

8.4 (8.2)

< 0.001

81.5 (60.9)

73.6 (59.3)

< 0.001

624.3 (489.0)

616.2 (477.2)

0.326

Subgroup analyses:

 Used only metformin in 2016 (n = 2271)

2271 (9632)

2184 (10,036)

1678

1681

4.2 (4.2)

4.6 (4.6)

0.007

63.6 (42.6)

61.1 (42.2)

< 0.001

269.6 (129.0)

280.9 (145.4)

0.006

 Used metformin and other OAD in 2016 (n = 1430)

1430 (12,946)

1412 (14,009)

2806

2700

9.1 (7.7)

9.9 (8.7)

0.005

79.1 (44.0)

70.3 (44.9)

< 0.001

716.3 (268.6)

697.9 (299.2)

0.084

 Used only other diabetes medications than insulin or metformin in 2016 (n = 726)

726 (4009)

694 (4316)

714

701

5.5 (5.3)

6.2 (5.6)

0.016

65.0 (41.9)

59.3 (39.7)

< 0.001

358.8 (169.4)

368.6 (193.9)

0.309

 Used insulin and OAD (incl. metformin) in 2016 (n = 2112)

2112 (25,656)

2088 (26,503)

6046

5745

12.1 (9.0)

12.7 (9.8)

0.061

86.0 (72.3)

79.2 (70.7)

< 0.001

1044.9 (572.1)

1004.9 (559.7)

0.022

 Used only insulin in 2016 (n = 577)

577 (2861)

548 (2893)

821

737

5.0 (2.5)

5.3 (3.2)

0.064

104.8 (77.0)

93.0 (70.4)

< 0.001

519.6 (440.6)

490.8 (413.1)

0.259

 Patients alive on Oct 1, 2019 (n = 7669)

6730 (51,486)

6721 (56,235)

11,526

11,372

7.7 (7.3)

8.4 (8.2)

< 0.001

81.7 (60.7)

73.8 (59.3)

< 0.001

625.1 (488.6)

617.6 (477.9)

0.366

  1. Abbreviations: DDD defined daily dose, OAD oral antidiabetic drug