Table 2 Input values used in the analysis for vaginal delivery
From: Economic evaluation of carbetocin as prophylaxis for postpartum hemorrhage in the Philippines
Parameters | Values | Standard error | Distribution | Source |
|---|---|---|---|---|
Probability parameters | ||||
 Probability of needing treatment dose with oxytocin, VD | 0.1067 | 0.0025 | beta | Meta-analysis [2] |
 Probability of needing blood transfusion with oxytocin, VD | 0.0134 | 0.0153 | beta | Meta-analysis [2] |
 Probability of needing hysterectomy with oxytocin, VD | 0.0013 | 0.0003 | beta | Global survey [29] |
 Probability of maternal deaths with oxytocin, VD | 0.0013 | 0.0003 | beta | Global survey [29] |
 Risk ratio of carbetocin as prophylaxis in VD (PPH ≥ 500 mL) | 0.67 | 0.12 | lognormal | Meta-analysis [2] |
 Probability of needing treatment dose with carbetocin, VD | 0.0715 | 0.0025 | beta | Meta-analysis [2] |
 Probability of needing blood transfusion with carbetocin, VD | 0.0091 | 0.0153 | beta | Meta-analysis [2] |
 Probability of needing hysterectomy with carbetocin, VD | 0.00089 | 0.0003 | beta | Global survey [29] |
Meta-analysis [2] | ||||
 Probability of maternal deaths with carbetocin, VD | 0.00089 | 0.0003 | beta | Global survey [29] |
Meta-analysis [2] | ||||
Cost parameters | ||||
 Direct medical costs | ||||
  No complication (n = 38) | 180.09 | 6.15 | gamma | Primary data collection |
  Additional treatment dose (n = 37) | 185.54 | 10.35 | gamma | Primary data collection |
  Blood transfusion (n = 13) | 316.12 | 11.54 | gamma | Primary data collection |
  Hysterectomy (n = 12)a | 987.68 | 87.05 | gamma | Primary data collection |
 Direct non-medical costs | ||||
  No complication | 33.84 | 2.22 | gamma | Primary data collection |
  Additional treatment dose | 35.38 | 2.72 | gamma | Primary data collection |
  Blood transfusion | 48.55 | 5.25 | gamma | Primary data collection |
  Hysterectomy | 57.08 | 5.82 | gamma | Primary data collection |
 Indirect cost of one caregiver | ||||
  No complication | 58.88 | 4.41 | gamma | Primary data collection |
  Additional treatment dose | 59.27 | 5.09 | gamma | Primary data collection |
  Blood transfusion | 62.49 | 4.50 | gamma | Primary data collection |
  Hysterectomy | 57.08 | 5.82 | gamma | Primary data collection |
Utility parameters | ||||
 Utility in VD, no complications (n = 108) | 0.85 | 0.01 | beta | Primary data collection |
 Utility in VD, with PPH episode (n = 8) | 0.78 | 0.03 | beta | Primary data collection |
 Utility in VD, with hysterectomy | 0.50 | – |  | Visual analogue scale, expert advise [30] |