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Table 2 Input values used in the analysis for vaginal delivery

From: Economic evaluation of carbetocin as prophylaxis for postpartum hemorrhage in the Philippines

Parameters Values Standard error Distribution Source
Probability parameters
 Probability of needing treatment dose with oxytocin, VD 0.1067 0.0025 beta Meta-analysis [2]
 Probability of needing blood transfusion with oxytocin, VD 0.0134 0.0153 beta Meta-analysis [2]
 Probability of needing hysterectomy with oxytocin, VD 0.0013 0.0003 beta Global survey [29]
 Probability of maternal deaths with oxytocin, VD 0.0013 0.0003 beta Global survey [29]
 Risk ratio of carbetocin as prophylaxis in VD (PPH ≥ 500 mL) 0.67 0.12 lognormal Meta-analysis [2]
 Probability of needing treatment dose with carbetocin, VD 0.0715 0.0025 beta Meta-analysis [2]
 Probability of needing blood transfusion with carbetocin, VD 0.0091 0.0153 beta Meta-analysis [2]
 Probability of needing hysterectomy with carbetocin, VD 0.00089 0.0003 beta Global survey [29]
Meta-analysis [2]
 Probability of maternal deaths with carbetocin, VD 0.00089 0.0003 beta Global survey [29]
Meta-analysis [2]
Cost parameters
Direct medical costs
  No complication (n = 38) 180.09 6.15 gamma Primary data collection
  Additional treatment dose (n = 37) 185.54 10.35 gamma Primary data collection
  Blood transfusion (n = 13) 316.12 11.54 gamma Primary data collection
  Hysterectomy (n = 12)a 987.68 87.05 gamma Primary data collection
Direct non-medical costs
  No complication 33.84 2.22 gamma Primary data collection
  Additional treatment dose 35.38 2.72 gamma Primary data collection
  Blood transfusion 48.55 5.25 gamma Primary data collection
  Hysterectomy 57.08 5.82 gamma Primary data collection
Indirect cost of one caregiver
  No complication 58.88 4.41 gamma Primary data collection
  Additional treatment dose 59.27 5.09 gamma Primary data collection
  Blood transfusion 62.49 4.50 gamma Primary data collection
  Hysterectomy 57.08 5.82 gamma Primary data collection
Utility parameters
 Utility in VD, no complications (n = 108) 0.85 0.01 beta Primary data collection
 Utility in VD, with PPH episode (n = 8) 0.78 0.03 beta Primary data collection
 Utility in VD, with hysterectomy 0.50   Visual analogue scale, expert advise [30]
  1. PPH Postpartum hemorrhage, asame with cost in CS with hysterectomy