Table 1 Input values used in the analysis for cesarean section
From: Economic evaluation of carbetocin as prophylaxis for postpartum hemorrhage in the Philippines
Parameters | Values | Standard error | Distribution | Source |
|---|---|---|---|---|
Probability parameters | ||||
 Probability of needing treatment dose with oxytocin, CS | 0.2318 | 0.0119 | beta | Meta-analysis [2] |
 Probability of needing blood transfusion with oxytocin, CS | 0.0287 | 0.0390 | beta | Meta-analysis [2] |
 Probability of needing hysterectomy with oxytocin, CS | 0.00134 | 0.0003 | beta | Global survey [29] |
 Probability of maternal deaths with oxytocin, CS | 0.00134 | 0.0003 | beta | Global survey [29] |
 Risk ratio of carbetocin as prophylaxis in CS (PPH ≥ 1000 mL) | 0.62 | 0.23 | lognormal | Meta-analysis [2] |
 Probability of needing treatment dose with carbetocin, CS | 0.1437 | 0.0119 | beta | Meta-analysis [2] |
 Probability of needing blood transfusion with carbetocin, CS | 0.0178 | 0.0390 | beta | Meta-analysis [2] |
 Probability of needing hysterectomy with carbetocin, CS | 0.00083 | 0.0003 | beta | Global survey [29] |
Meta-analysis [2] | ||||
 Probability of maternal deaths with carbetocin, CS | 0.00083 | 0.0003 | beta | Global survey [29] |
Meta-analysis [2] | ||||
Cost parameters | ||||
 Direct medical costs | ||||
  No complication (n = 31) | 445.01 | 13.87 | gamma | Primary data collection |
  Additional treatment dose (n = 31) | 465.04 | 11.46 | gamma | Primary data collection |
  Blood transfusion (n = 13) | 584.99 | 22.98 | gamma | Primary data collection |
  Hysterectomy (n = 12) | 987.68 | 87.05 | gamma | Primary data collection |
 Direct non-medical costs | ||||
  No complication | 33.12 | 2.11 | gamma | Primary data collection |
  Additional treatment dose | 45.17 | 2.49 | gamma | Primary data collection |
  Blood transfusion | 54.57 | 8.32 | gamma | Primary data collection |
  Hysterectomy | 57.08 | 5.82 | gamma | Primary data collection |
 Indirect cost of one caregiver | ||||
  No complication | 50.79 | 2.28 | gamma | Primary data collection |
  Additional treatment dose | 67.24 | 3.93 | gamma | Primary data collection |
  Blood transfusion | 85.77 | 12.84 | gamma | Primary data collection |
  Hysterectomy | 57.08 | 5.82 | gamma | Primary data collection |
Utility parameters | ||||
 Utility in CS, no complications (n = 77) | 0.83 | 0.02 | beta | Primary data collection |
 Utility in CS, with PPH episode (n = 3) | 0.67 | 0.15 | beta | Primary data collection |
 Utility in CS, with hysterectomy | 0.50 | – |  | Visual analogue scale, expert advise [30] |