Scenario | Description | Components and context |
---|---|---|
0) SAFER Study | Total cost as observed in the clinical trial, including high intensity of resource use and above-market prices. Incremental to current practice as observed in trial. | • High private sector prices • Monthly visits and monitoring until pregnancy confirmed • Up to 12 months of conception attempts • 100% of trial participants used MOHCC delivered ART, therefore no ART cost included in this scenario • Full costs for delivery of VL testing, PrEP, AVI, and SW |
1) High Intensity + Real-world Prices | Same resource intensity as above, but using prices normally paid by the Zimbabwe MOHCC. | • Public sector prices • Monthly visits and monitoring until pregnancy confirmed • Up to 12 months of conception attempts • Full costs for delivery of VL testing, PrEP, AVI, and SW |
2) Target Intensity, Incremental Cost Added to Current Practice | Target resource intensitya, incremental to current population service coverage for HIV treatment and prevention. | • Public sector prices • After strategy initiation, visits and monitoring q3–6 months until pregnancy confirmed • Up to 12 months of conception attempts • With 72% ART coverage in community, includes costs to provide ART for 28% of HIV+, ART-naive individuals • Includes costs for needed VL tests beyond those recommended in MOHCC guidelines • Full costs for delivery of PrEP, AVI, SW, safer conception counselling |
3) Target Intensity, Incremental Cost Added to Standard of Care | Same as above, except incremental to current MOHCC-specified standard of care. | • Public sector prices • After strategy initiation, visits and monitoring q3–6 months until pregnancy confirmed • Up to 12 months of conception attempts • No costs for ART and PrEP, which are in MOHCC guidelines as standard of care • Includes costs for needed VL tests beyond those recommended in MOHCC guidelines • Includes full costs for delivering AVI, SW, safer conception counselling |