Table 2 Comparison of PROMs in the EMPATHY Trial
|  | ESAS-r: Renal | IPOS-Renal | EQ-5D-5 L |
|---|---|---|---|
Type of PROM | Disease-specific (renal) measure | Disease-specific (renal) measure | Generic, preference-based HRQL measure |
Use by Renal Programs | •AKC-N •ORN •Study groups 1 and 3 | •AKC-S •Study groups 1 and 3 | •AKC-N •AKC-S •ORN •Study groups 2 and 3 |
Measurement Properties | •Clinically validated and reliable •Sensitive to change | •Clinically validated and reliable •Sensitive to change | Limited evidence for clinical use •Produces utility scores •Comparison with any population, including population norms |
Content | Symptoms: •Pain •Tiredness •Drowsiness •Nausea •Lack of appetite •Shortness of breath •Depression •Anxiety •Wellbeing •Itch •Problems sleeping •Restless legs | Symptoms: •Pain •Shortness of breath •Weakness or lack of energy •Nausea •Vomiting •Poor appetite •Constipation •Sore or dry mouth •Drowsiness •Poor mobility •Itch •Difficulty sleeping •Restless legs •Changes in skin •Diarrhea •Anxiety •Depression Other: Information needs, practical concerns, family anxieties, and overall feeling of being at peace | Problems: •Mobility •Selfcare •Usual activities •Pain/discomfort •Anxiety/depression Visual Analogue Scale: overall health state |
Number of items/dimensions | 12 | 26 | 5 + VAS |
Scale | 0–10 | 0–4 | 5 dimensions: 1–5 categorical Index score: 0-dead, 1-full health VAS: 0–100 |