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Table 2 Percentage distribution of type of drug switch per active substance (GG = generic drug to generic drug switch, BG = brand-name drug to generic drug switch, GB = generic drug to brand-name drug switch, and BB = brand-name drug to brand-name drug switch) in descending order by percentage of generic-to-generic drug switch in the last period, similar to the order in Fig. 3. Periods are June 2009 to December 2011, January 2012 to June 2014, and July 2014 to December 2016

From: Drug switching in the Netherlands: a cohort study of 20 active substances

  June 2009 to December 2011 January 2012 to June 2014 July 2014 to December 2016
GG BG GB BB GG BG GB BB GG BG GB BB
metformin 99.9 0.07 0.01 0.00 100 0.00 0.00 0.00 100 0.00 0.00 0.00
methotrexate (immunosuppressive) 100 0.00 0.00 0.00 100 0.00 0.00 0.00 100 0.00 0.00 0.00
enalapril 99.3 0.46 0.27 0.00 99.5 0.32 0.16 0.00 99.7 0.17 0.13 0.00
simvastatin 99.2 0.39 0.38 0.07 99.1 0.27 0.14 0.44 99.7 0.12 0.09 0.09
atorvastatin 0.00 0.00 0.00 100 56.0 33.2 1.34 9.44 99.1 0.50 0.37 0.00
pantoprazole 65.8 26.4 3.64 4.10 97.5 1.46 1.02 0.01 99.1 0.49 0.43 0.03
perindopril 96.4 0.03 0.01 3.54 98.0 0.02 0.00 2.01 99.0 0.05 0.03 0.93
paroxetine 96.3 1.67 1.98 0.00 97.2 1.55 1.23 0.00 97.9 0.74 0.74 0.61
metoprolol 95.3 3.17 1.44 0.06 96.2 2.10 0.99 0.71 97.3 0.91 0.65 1.11
venlafaxine 84.3 10.4 4.88 0.38 95.5 2.61 1.90 0.01 96.2 1.44 1.46 0.91
ethinylestradiol/
levonorgestrel
25.7 46.0 14.9 13.4 73.8 13.2 10.5 2.56 94.3 1.16 1.23 3.31
irbesartan 0.00 0.00 0.00 100 58.1 38.5 3.44 0.00 91.1 2.25 6.59 0.08
esomeprazole 10.8 38.0 9.05 42.2 70.7 12.4 6.34 10.6 82.3 3.77 3.65 10.2
methylphenidate 72.6 11.1 11.7 4.57 69.1 18.5 9.70 2.61 63.1 20.3 14.6 1.90
omeprazole 97.2 1.31 1.37 0.07 94.2 3.11 2.65 0.01 62.0 13.3 24.7 0.07
salbutamol 46.4 29.3 16.6 7.60 55.0 21.1 15.3 8.61 57.9 17.8 20.1 4.24
losartan 35.3 32.6 3.34 28.8 77.8 8.06 11.1 3.01 45.3 10.7 41.7 2.18
rivastigmine 14.0 75.6 10.3 0.08 20.9 14.8 2.67 61.6 43.8 35.0 12.9 8.33
salmeterol/
fluticasone
0.00 0.00 0.00 100 0.00 0.65 0.20 99.1 16.3 29.3 9.78 44.6
levothyroxine 0.15 19.1 21.3 59.4 2.19 29.9 21.7 46.2 1.72 26.1 5.89 66.3
methotrexate (antineoplastic) 0.00 9.04 1.66 89.3 0.00 0.03 0.00 100 0.25 0.02 0.00 99.7
Average 75.0 8.31 2.22 14.5 84.1 7.14 2.18 6.54 82.2 5.59 6.63 5.53