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Table 4 Characteristics of the 13 studies not providing any justification for the patient relevance of outcomes

From: Patient-relevant outcomes: what are we talking about? A scoping review to improve conceptual clarity

Authors Objective/ motivation of article Type of article/ study Terms used synonymously Indicator disease/
intervention
Outcomes considered patient-relevant [instrument, if applicable]
Agarwal et al. 2017 [40] Examination to what extent Cochrane and non-Cochrane reviews report absolute effects for patient-important outcomes in the abstract Systematic review 1 term:
- patient-important outcome
Generic - mortality
- morbidity
- symptoms
- quality of life
- functional status
Cao et al. 2014 [41] Comparison of the efficacy of two commonly used Chinese patent medicines for patients with angina pectoris Study protocol for a randomized controlled trial 1 term:
- patient-important outcome
Angina pectoris - short of breath
- fatigue
- palpitations
- sweating
Cleveringa et al. 2010 [42] Determination of the effects of the Diabetes Care Protocol on patient-important outcomes
Note: When applying the Diabetes Care Protocol, routine diabetes care is delegated to a nurse, who uses a computerized decision support system to structure diabetes care and set targets
Cluster-randomized trial 1 term:
- patient-important outcome
Type 2 diabetes - diabetes-specific health status: psychological distress, barriers to activity, disinhibited eating [DHP-18]
- general health status [SF-36, EQ-5D]
- treatment satisfaction [DTSQ-status]
- self-efficacy [DES-SF]
Englund et al. 2001 [43] Evaluation of long-term patient-relevant outcomes after removal of knee meniscus Retrospective cohort study 2 terms:
- patient-relevant outcome
- self-administered outcome measure
Meniscectomy - general health status [SF-36]
- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life [KOOS]
Gandhi et al. 2008 [3] Determination to what extent registered randomized controlled trials among patients with diabetes plan to assess patient-important outcomes Systematic review 1 term:
- patient-important outcome
Diabetes - mortality
- quality of life
- major morbid events
- minor morbid events
- pain
- functional status
Griffith et al. 2019 [44] Determination how different disease frameworks impact the prevalence of multimorbidity and its association with patient-important outcomes Baseline analysis of a population-based cohort study 2 terms:
- patient-important functional outcome
- patient-important outcome
Generic; community-living adults aged 45 to 85 years - functional disability [OARS questionnaire]
- social participation restriction
- self-rated physical health
- self-rated mental health
Nilsdotter et al. 2003 [45] Evaluation of long-term patient-relevant outcomes after unilateral total hip replacement for osteoarthritis Case-control-study 1 term:
- patient relevant outcome
Unilateral total hip replacement for osteoarthritis - general health status [SF-36]
- knee-specific health status: pain, stiffness, physical function [WOMAC]
- postoperative complications
- general comorbidity
- musculoskeletal comorbidity: need of walking assistance, walking distance, pain, need for analgesics, joint replacement in contralateral hip or in knee, fractures
- patient satisfaction
Paradowski et al. 2004 [46] Assessment of variation in knee pain, function, and quality of life over two years after removal of knee meniscus in patients with and and without radiographic knee osteoarthritis Prospective follow-up study 1 term:
- patient-relevant outcome
Meniscectomy - knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life [KOOS]
Porat et al. 2004 [47] Identification of the consequences of an anterior cruciate ligament tear 14 years after injury in a cohort of male soccer players regarding radiographic knee osteoarthritis
and patient-relevant outcomes
Prospective cohort study 1 term:
- patient relevant outcome
Anterior cruciate ligament tear - general health status [SF-36]
- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life, functional disability [KOOS, Lysholm Knee Score]
Ramar et al. 2017 [48] Synthesis of the literature with regard to models of care targeting patient-important outcomes for maintenance dialysis patients focusing on hospitalization and mortality Systematic review & meta-analysis 2 terms:
- patient-important outcome
- patient outcome
Maintenance dialysis care - mortality
- hospitalization
Schnabel et al. 2014 [49] Comparison of the analgesic efficacy and safety of ultrasound and nerve stimulator guided peripheral nerve catheters for postoperative pain therapy Retrospective database analysis 4 terms:
- patient-relevant target parameter
- patient-related outcome
- patient-relevant parameter [German: Patienten-relevanter Parameter]
- patient-relevant efficacy parameter [German: Patienten-relevanter Effektivitätsparameter]
Peripheral nerve catheters for pain therapy - postoperative pain
- postoperative need for additional opioids
- cumulative local anesthetic consumption
- puncture-associated complications
- postoperative catheter-related complications
Stallmach et al. 2015 [50] Examination of possible improvements in the clinical situation of patients with inflammatory bowel disease in Germany, focusing on patient-relevant endpoints Secondary data analysis 1 term:
- patient-relevant endpoint
Inflammatory bowel diseases - number of stationary treatments per year (cases)
- average residence time
- number of operations
- inability to work
- premature mortality
W-Dahl et al. 2005 [51] Evaluation of the patient-relevant outcomes pain, function, and quality of life during two years in patients operated on for knee osteoarthritis with tibial osteotomy Prospective follow-up study 1 term:
- patient-relevant outcome
Tibial osteotomy for uni-compartmental
knee osteoarthritis
- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life [KOOS]
- complications, e.g., delayed healing, deep venous thrombosis