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Table 4 Characteristics of the 13 studies not providing any justification for the patient relevance of outcomes

From: Patient-relevant outcomes: what are we talking about? A scoping review to improve conceptual clarity

Authors

Objective/ motivation of article

Type of article/ study

Terms used synonymously

Indicator disease/

intervention

Outcomes considered patient-relevant [instrument, if applicable]

Agarwal et al. 2017 [40]

Examination to what extent Cochrane and non-Cochrane reviews report absolute effects for patient-important outcomes in the abstract

Systematic review

1 term:

- patient-important outcome

Generic

- mortality

- morbidity

- symptoms

- quality of life

- functional status

Cao et al. 2014 [41]

Comparison of the efficacy of two commonly used Chinese patent medicines for patients with angina pectoris

Study protocol for a randomized controlled trial

1 term:

- patient-important outcome

Angina pectoris

- short of breath

- fatigue

- palpitations

- sweating

Cleveringa et al. 2010 [42]

Determination of the effects of the Diabetes Care Protocol on patient-important outcomes

Note: When applying the Diabetes Care Protocol, routine diabetes care is delegated to a nurse, who uses a computerized decision support system to structure diabetes care and set targets

Cluster-randomized trial

1 term:

- patient-important outcome

Type 2 diabetes

- diabetes-specific health status: psychological distress, barriers to activity, disinhibited eating [DHP-18]

- general health status [SF-36, EQ-5D]

- treatment satisfaction [DTSQ-status]

- self-efficacy [DES-SF]

Englund et al. 2001 [43]

Evaluation of long-term patient-relevant outcomes after removal of knee meniscus

Retrospective cohort study

2 terms:

- patient-relevant outcome

- self-administered outcome measure

Meniscectomy

- general health status [SF-36]

- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life [KOOS]

Gandhi et al. 2008 [3]

Determination to what extent registered randomized controlled trials among patients with diabetes plan to assess patient-important outcomes

Systematic review

1 term:

- patient-important outcome

Diabetes

- mortality

- quality of life

- major morbid events

- minor morbid events

- pain

- functional status

Griffith et al. 2019 [44]

Determination how different disease frameworks impact the prevalence of multimorbidity and its association with patient-important outcomes

Baseline analysis of a population-based cohort study

2 terms:

- patient-important functional outcome

- patient-important outcome

Generic; community-living adults aged 45 to 85 years

- functional disability [OARS questionnaire]

- social participation restriction

- self-rated physical health

- self-rated mental health

Nilsdotter et al. 2003 [45]

Evaluation of long-term patient-relevant outcomes after unilateral total hip replacement for osteoarthritis

Case-control-study

1 term:

- patient relevant outcome

Unilateral total hip replacement for osteoarthritis

- general health status [SF-36]

- knee-specific health status: pain, stiffness, physical function [WOMAC]

- postoperative complications

- general comorbidity

- musculoskeletal comorbidity: need of walking assistance, walking distance, pain, need for analgesics, joint replacement in contralateral hip or in knee, fractures

- patient satisfaction

Paradowski et al. 2004 [46]

Assessment of variation in knee pain, function, and quality of life over two years after removal of knee meniscus in patients with and and without radiographic knee osteoarthritis

Prospective follow-up study

1 term:

- patient-relevant outcome

Meniscectomy

- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life [KOOS]

Porat et al. 2004 [47]

Identification of the consequences of an anterior cruciate ligament tear 14 years after injury in a cohort of male soccer players regarding radiographic knee osteoarthritis

and patient-relevant outcomes

Prospective cohort study

1 term:

- patient relevant outcome

Anterior cruciate ligament tear

- general health status [SF-36]

- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life, functional disability [KOOS, Lysholm Knee Score]

Ramar et al. 2017 [48]

Synthesis of the literature with regard to models of care targeting patient-important outcomes for maintenance dialysis patients focusing on hospitalization and mortality

Systematic review & meta-analysis

2 terms:

- patient-important outcome

- patient outcome

Maintenance dialysis care

- mortality

- hospitalization

Schnabel et al. 2014 [49]

Comparison of the analgesic efficacy and safety of ultrasound and nerve stimulator guided peripheral nerve catheters for postoperative pain therapy

Retrospective database analysis

4 terms:

- patient-relevant target parameter

- patient-related outcome

- patient-relevant parameter [German: Patienten-relevanter Parameter]

- patient-relevant efficacy parameter [German: Patienten-relevanter Effektivitätsparameter]

Peripheral nerve catheters for pain therapy

- postoperative pain

- postoperative need for additional opioids

- cumulative local anesthetic consumption

- puncture-associated complications

- postoperative catheter-related complications

Stallmach et al. 2015 [50]

Examination of possible improvements in the clinical situation of patients with inflammatory bowel disease in Germany, focusing on patient-relevant endpoints

Secondary data analysis

1 term:

- patient-relevant endpoint

Inflammatory bowel diseases

- number of stationary treatments per year (cases)

- average residence time

- number of operations

- inability to work

- premature mortality

W-Dahl et al. 2005 [51]

Evaluation of the patient-relevant outcomes pain, function, and quality of life during two years in patients operated on for knee osteoarthritis with tibial osteotomy

Prospective follow-up study

1 term:

- patient-relevant outcome

Tibial osteotomy for uni-compartmental

knee osteoarthritis

- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life [KOOS]

- complications, e.g., delayed healing, deep venous thrombosis