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Table 2 Characteristics of the 12 articles referring to other studies or special classifications to justify patient relevance of outcomes

From: Patient-relevant outcomes: what are we talking about? A scoping review to improve conceptual clarity

Authors Objective/ motivation of article Type of article/ study Terms used synonymously Indicator disease/intervention Outcomes considered patient-relevant [instrument, if applicable]
Adie et al. 2017 [4] Determination of the proportion of patient-important primary outcomes in surgical randomized controlled trials Systematic review & meta-analysis 2 terms:
- patient-important outcome
- patient-centered outcome
Surgical interventions - mortality/survival
- pain
- function
- quality of life
- any morbid event or symptom
- patient satisfaction
- any intervention to address the previous outcomes
Ameur et al. 2017 [27] Determination whether recently published an ongoing systematic reviews with meta-analyses of therapeutic interventions assess patient-important outcomes Methodological review 1 term:
- patient-important outcome
Generic; therapeutic interventions - mortality
- clinical events
- pain
- quality of life
- therapeutic decision
- function
Fei et al. 2018 [28] Examination of the impact of adding ezetimibe to statins on patient-important outcomes in patients at high cardiovascular risk Narrative systematic review 1 term:
- patient-important outcome
High cardiovascular risk - all-cause mortality
- cardiovascular mortality
- non-fatal stroke
- non-fatal myocardial infarction
- adverse events
Gaudry et al. 2017 [5] Investigation whether randomized controlled trials in critically ill patients assess patient-important outcomes Systematic review 1 term:
- patient-important outcome
Critical illness - mortality
- quality of life after Intensive Care Unit discharge
- functional, cognitive, and neurological outcomes after Intensive Care Unit discharge
Kvitkina et al. 2014 [29] Description of the feasibility of the early benefit assessment of novel agents on the basis of patient-relevant outcomes by characterizing the outcomes available in the companies dossiers and comparing them to outcomes defined as patient-relevant by the German Institute for Quality and Efficiency in Health Care Systematic Review 1 term:
- patient-relevant outcome
Drugs (novel agents) - mortality
- morbidity
- health-related quality of life
- adverse events
Roos et al. 2000 [30] Evaluation of patient-relevant outcomes preoperatively and three months after partial meniscectomy Prospective follow-up study 1 term:
- patient-relevant outcome
Partial meniscectomy - general health status [SF-36]
- knee-specific health status: pain, symptoms, activities of daily life, sports and recreation function, knee-related quality of life, functional disability [KOOS, Lysholm Knee Score]
Schumacher et al. 2016 [31] Assessment of current approaches to measure the impact of tuberculosis nucleic acid amplification tests on patient-important outcomes in adults with possibly tuberculosis and/or drug-resistant tuberculosis Methodological review 2 terms:
- patient-important outcome
- patient outcome
Tuberculosis nucleic acid amplification tests - culture conversion
- tuberculosis treatment outcomes
- infection control/ contact tracing
- morbidity
- mortality
Singh et al. 2017 [32] Simulation of the long-term effect of novel agents versus chemotherapy-based regimens on progression-free survival, overall survival and health-related quality of life in patients with chronic lymphocytic leukemia Review & data simulation 2 terms:
- patient-relevant outcome
- patient-relevant benefit
Chronic lymphocytic leukemia - progression-free survival
- overall survival
- quality-adjusted life years
- post-progression survival
Wieseler et al. 2013 [33] Determination of the information gain between clinical study reports and publicly available sources for patient-relevant outcomes included in health technology assessments for drugs Systematic review 2 terms:
- patient-relevant clinical trial outcome
- patient-relevant outcome
Drugs - mortality
- clinical events
- symptoms
- health-related quality of life
- (serious) adverse events
Yordanov et al. 2018 [34] 1. Evaluation whether the outcomes reported in the summary of finding table of Cochrane reviews could be considered patient-important
2. Evaluation of the quality of evidence for these outcomes
Methodological review 1 term
- patient-important outcome / PIO
Generic - mortality
- other clinical events (e.g., myocardial infarction, stroke)
- adverse events
- function (e.g., anxiety, depression, disability)
- pain
- quality of life
- therapeutic decisions
El Dib et al. 2017 [35] Review of randomized controlled trials on diagnostic tests with regard to their topic areas, population, setting, study groups, patient-important outcomes, risk of bias, and results Systematic review 1 term:
- patient-important outcome
Diagnostic tests - mortality
- morbidity
- symptoms
- quality of life
- functional status
Fayed et al. 2014 [36] 1. Review to which extent activity and participation outcomes are included in pediatric clinical trials
2. Determination what characteristics are associated with using theses outcomes
Systematic review 3 terms:
- patient-important outcome
- patient-important activity and participation outcome
- child and family-important outcome
Generic; children with chronic conditions - body function
- activity
- participation
- environmental factors
- personal factors
- health condition
- general health