Skip to main content

Table 2 Summary of per person costs of genomic sequencing (AU$)

From: Estimating the costs of genomic sequencing in cancer control

 

Lung cancer/melanoma

Breast cancer

Melanoma

Lung cancer

Oesophageal cancer

Mesothelioma

No. of patients

745

192

383

10

100

3

Description

tumour samples

panel

blood samples

panel

saliva samples

exome

blood/tumour pairs

exome

blood/tumour pairs

genome

blood/tumour pairs

genome

1.Sampling

  -saliva/blooda

$0.00

$25.05

$27.50

$25.05

$25.05

$25.05

 % of total

0.0%

7.2%

3.2%

0.9%

0.5%

0.9%

2.DNA extraction

  -consumablesb

$22.13

$39.37

$19.28

$39.99

$84.19

$72.69

  -validation / quality control

$5.34

$5.34

$32.91

$81.50

$180.70

$139.90

 -labour

$0.78

$0.78

$13.86

$63.86

$35.39

$31.05

  % of total

6.6%

13.1%

7.6%

6.6%

6.2%

8.4%

3.Library preparation & Capture

  -consumablesc

$322.23

$149.67

Included in sequencing

$1050.21

Included in sequencing

Included in sequencing

  -pre-sequencing quality control

$0.78

 

n/a

$11.54

n/a

n/a

  -labour

$6.31

$6.79

n/a

$139.72

n/a

n/a

  % of total

76.8%

45.1%

 

43.1%

  

4.Sequencing

  -testing

n/a

$79.67

$750.00

$1111.75

$4188.60

$1631.26d

  -labour

n/a

$3.88

Included above

$69.86

Included above

Included above

  % of total

0.0%

24.1%

86.1%

42.4%

86.7%

56.3%

5. Analysis

  -computing software

$1.74

$3.20

n/a

$0.73

n/a

n/a

  -labour

$59.74

$23.82

$17.29

$57.63

$98.54

$777.96

  % of total

14.3%

7.8%

2.0%

2.1%

2.0%

26.9%

6. Storage

  -data storage

$1.96

$1.96

$9.79

$39.15

$217.28

$217.28

  % of total

0.5%

0.6%

1.1%

1.4%

4.5%

7.5%

7. Reporting to clinicians

  -multidisciplinary team meeting

$7.56

$7.56

n/a (project is pre-clinical)

$96.54

n/a (project is pre-clinical)

n/a (project is pre-clinical)

  % of total

1.8%

2.2%

    

TOTAL per person

AU$428.56 (US$240)

AU$347.08 (US$297)

AU$870.63 (US$604)

$2787.53 (US$1932)

AU$4829.76 (US$3447)

AU$2895.19 (US$2006)

Capital costs

  -sequencing machine

$22.46

$22.46

$61.58

$131.01

$62.45

$74.24

  -maintenance

$11.23

$11.23

$30.79

$65.51

$31.22

$37.12

Total

$33.69

$33.69

$92.36

$196.52

$93.67

$111.36

% extra from total per person

7.9%

9.7%

10.6%

7.0%

1.9%

3.8%

TOTAL per person including capital

$462.25

$380.77

$963.00

$2984.07

$4923.53

$3006.65

  1. aThe costs of tumour samples were not included because these were routinely biopsied in the normal course of diagnosis and not specifically for sequencing
  2. bIncludes tube racks, plate racks, storage racks, tips, tubes, ethanol, tube & lid cap strips, sealing film, DNA gel stain, gel extraction kit, microplate buffer etc. (see Additional file 1 for details)
  3. cIncludes reagents, tips, beads, prep kit, microtubes, plates, PCR plates, TapeStation Assay (see Additional file 1 for details)
  4. dUSD 600 converted to AUD xe.com, 1.29038 exchange rate