Table 2 Summary of per person costs of genomic sequencing (AU$)
From: Estimating the costs of genomic sequencing in cancer control
Lung cancer/melanoma | Breast cancer | Melanoma | Lung cancer | Oesophageal cancer | Mesothelioma | |
|---|---|---|---|---|---|---|
No. of patients | 745 | 192 | 383 | 10 | 100 | 3 |
Description | tumour samples panel | blood samples panel | saliva samples exome | blood/tumour pairs exome | blood/tumour pairs genome | blood/tumour pairs genome |
1.Sampling | ||||||
-saliva/blooda | $0.00 | $25.05 | $27.50 | $25.05 | $25.05 | $25.05 |
% of total | 0.0% | 7.2% | 3.2% | 0.9% | 0.5% | 0.9% |
2.DNA extraction | ||||||
-consumablesb | $22.13 | $39.37 | $19.28 | $39.99 | $84.19 | $72.69 |
-validation / quality control | $5.34 | $5.34 | $32.91 | $81.50 | $180.70 | $139.90 |
-labour | $0.78 | $0.78 | $13.86 | $63.86 | $35.39 | $31.05 |
% of total | 6.6% | 13.1% | 7.6% | 6.6% | 6.2% | 8.4% |
3.Library preparation & Capture | ||||||
-consumablesc | $322.23 | $149.67 | Included in sequencing | $1050.21 | Included in sequencing | Included in sequencing |
-pre-sequencing quality control | $0.78 | n/a | $11.54 | n/a | n/a | |
-labour | $6.31 | $6.79 | n/a | $139.72 | n/a | n/a |
% of total | 76.8% | 45.1% | 43.1% | |||
4.Sequencing | ||||||
-testing | n/a | $79.67 | $750.00 | $1111.75 | $4188.60 | $1631.26d |
-labour | n/a | $3.88 | Included above | $69.86 | Included above | Included above |
% of total | 0.0% | 24.1% | 86.1% | 42.4% | 86.7% | 56.3% |
5. Analysis | ||||||
-computing software | $1.74 | $3.20 | n/a | $0.73 | n/a | n/a |
-labour | $59.74 | $23.82 | $17.29 | $57.63 | $98.54 | $777.96 |
% of total | 14.3% | 7.8% | 2.0% | 2.1% | 2.0% | 26.9% |
6. Storage | ||||||
-data storage | $1.96 | $1.96 | $9.79 | $39.15 | $217.28 | $217.28 |
% of total | 0.5% | 0.6% | 1.1% | 1.4% | 4.5% | 7.5% |
7. Reporting to clinicians | ||||||
-multidisciplinary team meeting | $7.56 | $7.56 | n/a (project is pre-clinical) | $96.54 | n/a (project is pre-clinical) | n/a (project is pre-clinical) |
% of total | 1.8% | 2.2% | ||||
TOTAL per person | AU$428.56 (US$240) | AU$347.08 (US$297) | AU$870.63 (US$604) | $2787.53 (US$1932) | AU$4829.76 (US$3447) | AU$2895.19 (US$2006) |
Capital costs | ||||||
-sequencing machine | $22.46 | $22.46 | $61.58 | $131.01 | $62.45 | $74.24 |
-maintenance | $11.23 | $11.23 | $30.79 | $65.51 | $31.22 | $37.12 |
Total | $33.69 | $33.69 | $92.36 | $196.52 | $93.67 | $111.36 |
% extra from total per person | 7.9% | 9.7% | 10.6% | 7.0% | 1.9% | 3.8% |
TOTAL per person including capital | $462.25 | $380.77 | $963.00 | $2984.07 | $4923.53 | $3006.65 |