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Table 2 The daily doses of dispensed potentially addictive drugs

From: Dispensations of benzodiazepines, z-hypnotics, and gabapentinoids to patients receiving opioid agonist therapy; a prospective cohort study in Norway from 2013 to 2017

a)
All indications 20132014201520162017
Benzodiazepine and z-hypnotic dose per patient (in diazepam equivalents) mean (lowest-highest)
Mean (mg/day)21 (17–29)20 (16–27)19 (15–25)17 (14–23)17 (14–22)
Median (mg/day)10 (9–12)10 (9–12)10 (8–12)10 (8–12)10 (8–11)
25 percentile (mg/day)3 (2–3)2 (2–3)3 (2–3)3 (2–3)3 (2–3)
75 percentile (mg/day)23 (20–29)22 (19–27)21 (18–26)21 (18–26)20 (18–25)
All indications 20132014201520162017
Pregabalin dose per patientMean (mg/day)365365371381386
Median (mg/day)205230249285255
25 percentile (mg/day)4674628469
75 percentile (mg/day)506552552561552
All indications 20132014201520162017
Gabapentin dose per patientMean (mg/day)9119709979601047
Median (mg/day)411488493493513
25 percentile (mg/day)821248282164
75 percentile (mg/day)12281314138312861430
b)
All indications 20132017   
  Mean dose (95 % CI)Mean dose (95% CI)   
 Diazepam equivalents per patient   
Benzodiazepine and z-hypnotic dose per patient (in diazepam equivalents)Mean (mg/day)21 (20–23)a17 (16–17)b   
 Pregabalin dose per patientMean (mg/day)365 (309–421)c386 (349–423)d   
Gabapentin dose per patientMean (mg/day)911 (753–1068)e1047 (885–1209)f   
  1. Df Degrees of freedom, Lowest Lowest equipotency dose, Highest Highest equipotency dose, and Mean = Min + Max divided by 2
  2. aOne sample t-test, df = 3746, bone sample t-test, df = 3761, cone sample t-test, df = 486, done sample t-test, df = 590, eone sample t-test, df = 260, and fone sample t-test, df = 309
  3. The table a) displays the daily doses (mean, median, 25 percentile, and 75 percentile) of dispensed benzodiazepines or z-hypnotics (calculated in diazepam equivalents), pregabalin and gabapentin per year among patients on OAT in Norway in period 2013 to 2017
  4. The table b) displays the mean daily doses of dispensed benzodiazepines or z-hypnotics (calculated in diazepam equivalents), pregabalin and gabapentin in 2013 and 2017. The 95% confidence intervals were calculated by one-sample t-test analyses
  5. For table a) and b), an equipotency table for benzodiazepines and z-hypnotics were used to make sensitivity analyses displaying the lowest equipotency dose and the highest equipotency dose of the included benzodiazepines and z-hypnotics. The results were presented in parentheses. All dispensed benzodiazepines and z-hypnotics were summarized per year