Table 1 Adverse event rates for vaccines containing whole-cell pertussis and acellular pertussis components [30]
Adverse Event | 1st Dose | 2nd Dose | 3rd Dose | |||
|---|---|---|---|---|---|---|
Whole-cell vaccine (%) | Acellular vaccine (%) | Whole-cell vaccine (%) | Acellular vaccine (%) | Whole-cell vaccine (%) | Acellular vaccine (%) | |
Fever between 100.1°-101 °F (37.8–38.38 °C) | 24.3 | 2.3 | 28.8 | 12.8 | 27.8 | 15.2 |
Fever between 101.1°-102 °F (38.39–38.89 °C) | 3.0 | 0.8 | 3.9 | 0.8 | 7.3 | 2.3 |
Fever > 102 °F (> 38.9 °C) | 0 | 0 | 1.4 | 0.8 | 2.6 | 0 |
Skin reddening (1-20 mm) | 40.8 | 13.5 | 41.6 | 24.1 | 44.4 | 25.8 |
Skin reddening (> 20 mm) | 8.6 | 0.8 | 6.1 | 1.5 | 3.2 | 3.0 |
Edema (1-20 mm) | 23.2 | 7.5 | 26.6 | 16.5 | 30.1 | 14.4 |
Edema (> 20 mm) | 16.5 | 0.8 | 9.5 | 0.8 | 5.6 | 3.8 |
Moderate pain | 17.6 | 2.3 | 12.6 | 3.0 | 12.0 | 3.8 |
Severe pain | 9.7 | 0 | 6.1 | 0 | 3.8 | 0 |
Moderate irritation | 16.8 | 3.8 | 16.5 | 6.0 | 12.6 | 4.5 |
Severe irritation | 3.8 | 0.8 | 7.0 | 0.8 | 4.7 | 0.8 |
Use of anti-pyretics | 60.5 | 35.3 | 59.8 | 35.3 | 61.4 | 33.3 |
Fatigue | 43.5 | 28.6 | 31.0 | 14.3 | 24.6 | 14.4 |
Reduced appetite | 19.5 | 7.5 | 16.5 | 4.5 | 14.3 | 12.1 |
Vomiting | 7.0 | 3.0 | 4.5 | 1.5 | 5.3 | 3.8 |