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Table 4 Bootstrapped results of the base case, sensitivity and subgroup analyses of all three study outcomes (UPCC, USER-Participation and QALYs)

From: A trial-based economic evaluation of the Restore4Stroke self-management intervention compared to an education-based intervention for stroke patients and their partners

AnalysisaPatientsΔCosts (€)ΔEffectsICERDistribution cost-effectiveness plane (quadrant,%)b
SMIEDU   NESE (dominant)SWNW (inferior)
Base case UPCC58551921.60.0726,514.35422618
Sensitivity analyses5855       
  Unit price rehabilitation day  1489.50.0720,511.85221522
  Friction costs  784.30.0710,821.24727818
  Healthcare perspective  164.00.072263.341331115
Subgroup analysis4844       
  Complete cases  3143.00.1226,167.16913117
Base case USER-Participation58551921.65.56345.6722305
Sensitivity analyses5855       
  Unit price rehabilitation day  1489.55.56267.9682714
  Friction costs  784.35,56141.1603514
  Healthcare perspective  164.05.5629.5534214
Subgroup analysis4844       
  Complete cases  3143.04.86646.3771409
Base case QALY58551921.60.0444,687.9732304
Sensitivity analyses5855       
  Unit price rehabilitation day  1489.50.0434,638.6702613
  Friction costs  784.30.0418.238.4613612
  Healthcare perspective  164.00.043814.6534313
  Delta QALY  1921.60.1117,970.3752401
  QALY UK tariff  1921.60.0539,744.8752302
Subgroup analysis4844       
  Complete cases  3143.00.0557,702.2851402
  1. ICER incremental cost-effectiveness ratio, SMI self-management intervention, EDU education-based intervention
  2. aBase case analysis values a rehabilitation day as a hospital treatment day (€266.53), calculates production costs by means of human capital method, uses the societal perspective to calculate total costs, corrects for baseline differences with regression analysis and calculates utilities with a Dutch tariff
  3. Sensitivity analyses values a rehabilitation treatment day as a rehabilitation contact (€116.81), calculates production costs with the friction cost method, estimates total cost from a healthcare perspective, correction for baseline differences in utility scores with Delta QALY, utilities are calculated with a UK tariff, Subgroup analysis values complete cases defined as patients with more than 3 items missing on primary study outcomes (n = 44 education-based intervention and n = 48 self-management intervention
  4. bNE (northeast quadrant): SM more effective and more costly compared to Edu
  5. SE (southeast quadrant): SM more effective and less costly compared to Edu
  6. SW (southwest quadrant): SM less effective and less costly compared to Edu
  7. NW (northwest quadrant): SM less effective and more costly compared to Edu