A trial-based economic evaluation of the Restore4Stroke self-management intervention compared to an education-based intervention for stroke patients and their partners

Table 4 Bootstrapped results of the base case, sensitivity and subgroup analyses of all three study outcomes (UPCC, USER-Participation and QALYs)

Analysis^a	Patients		ΔCosts (€)	ΔEffects	ICER	Distribution cost-effectiveness plane (quadrant,%)^b
Analysis^a	SMI	EDU				NE	SE (dominant)	SW	NW (inferior)
Base case UPCC	58	55	1921.6	0.07	26,514.3	54	22	6	18
Sensitivity analyses	58	55
Unit price rehabilitation day			1489.5	0.07	20,511.8	52	21	5	22
Friction costs			784.3	0.07	10,821.2	47	27	8	18
Healthcare perspective			164.0	0.07	2263.3	41	33	11	15
Subgroup analysis	48	44
Complete cases			3143.0	0.12	26,167.1	69	13	1	17
Base case USER-Participation	58	55	1921.6	5.56	345.6	72	23	0	5
Sensitivity analyses	58	55
Unit price rehabilitation day			1489.5	5.56	267.9	68	27	1	4
Friction costs			784.3	5,56	141.1	60	35	1	4
Healthcare perspective			164.0	5.56	29.5	53	42	1	4
Subgroup analysis	48	44
Complete cases			3143.0	4.86	646.3	77	14	0	9
Base case QALY	58	55	1921.6	0.04	44,687.9	73	23	0	4
Sensitivity analyses	58	55
Unit price rehabilitation day			1489.5	0.04	34,638.6	70	26	1	3
Friction costs			784.3	0.04	18.238.4	61	36	1	2
Healthcare perspective			164.0	0.04	3814.6	53	43	1	3
Delta QALY			1921.6	0.11	17,970.3	75	24	0	1
QALY UK tariff			1921.6	0.05	39,744.8	75	23	0	2
Subgroup analysis	48	44
Complete cases			3143.0	0.05	57,702.2	85	14	0	2

ICER incremental cost-effectiveness ratio, SMI self-management intervention, EDU education-based intervention
^aBase case analysis values a rehabilitation day as a hospital treatment day (€266.53), calculates production costs by means of human capital method, uses the societal perspective to calculate total costs, corrects for baseline differences with regression analysis and calculates utilities with a Dutch tariff
Sensitivity analyses values a rehabilitation treatment day as a rehabilitation contact (€116.81), calculates production costs with the friction cost method, estimates total cost from a healthcare perspective, correction for baseline differences in utility scores with Delta QALY, utilities are calculated with a UK tariff, Subgroup analysis values complete cases defined as patients with more than 3 items missing on primary study outcomes (n = 44 education-based intervention and n = 48 self-management intervention
^bNE (northeast quadrant): SM more effective and more costly compared to Edu
SE (southeast quadrant): SM more effective and less costly compared to Edu
SW (southwest quadrant): SM less effective and less costly compared to Edu
NW (northwest quadrant): SM less effective and more costly compared to Edu

ISSN: 1472-6963