Developing an adapted Charlson comorbidity index for ischemic stroke outcome studies

Table 3 Comparison of Model performance among ischemic stroke patients in the validation cohort (N = 2331, discharged between April 1, 2012 and March 31, 2013)

Outcome	Model	H-L X^2† (df)	P value	C-statistic (95% CI)	P value*	cNRI^¥ (95% CI)	P value*
In-hospital mortality	Age/sex adjusted CCI	9.56 (8)	0.297	0.722 (0.688, 0.756)
	Age/sex adjusted ISCCI	8.35 (8)	0.400	0.729 (0.695, 0.762)	0.343	−0.121 (−0.260,0.017)	0.08
	Age/sex adjusted ISCCI-AF	22.01 (8)	0.005	0.720 (0.686, 0.753)	–	–
30-day mortality	Age/sex adjusted CCI	10.42 (8)	0.236	0.732 (0.700, 0.763)
	Age/sex adjusted ISCCI	11.65 (8)	0.234	0.746 (0.715, 0.777)	0.009	0.041 (−0.087,0.170)	0.53
	Age/sex adjusted ISCCI-AF	12.95 (8)	0.113	0.737 (0.706, 0.768)		–
One-year mortality	Age/sex adjusted CCI	7.38 (8)	0.391	0.760 (0.738, 0.783)
	Age/sex adjusted ISCCI	7.33 (8)	0.501	0.764 (0.741, 0.786)	0.398	−0.086 (−0.181,0.010)	0.08
	Age/sex adjusted ISCCI-AF	15.63 (8)	0.075	0.755 (0.732, 0.777)		–

H-L Hosmer-Lemeshow, cNRI continuous net reclassification improvement, CCI Charlson comorbidity index, ISCCI Ischemic stroke Charlson comorbidity index, ISCCI-AF Ischemic stroke Charlson comorbidity index with atrial fibrillation included in the development model
†chi-square
*p-value for Area Under the Curve (AUC) and cNRI difference between age&sex adjusted CCI and age&sex adjusted ISCCI
¥difference between age/sex adjusted CCI and age/sex adjusted ISCCI

ISSN: 1472-6963