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Table 2 Parameters of the model

From: Modeling patients’ time, travel, and monitoring costs in anticoagulation management: societal savings achievable with the shift from warfarin to direct oral anticoagulants

ParameterDescriptionValueUnitAdditional information
TTravel time using the fastest route on a road network minCalculated with network analysis
VOTThe value of time based on the average hourly income of a zip code area EURAverage hourly gross wage converted from the monthly gross wage in 2017
PPatient’s productivity coefficient1.00 or 0.35Used as weightDepicts patient’s lost contribution to the society. Working time is valued as 100% and leisure time as 35% of the hourly wage
TpPrivate car parking time5minAdded to the total journey time
DTravel distance calculated from the fastest route on a road network kmCalculated with network analysis
VOCVehicle operating cost   
 Private car0.45EUR/kmIncludes fuel cost and vehicle maintenance and depreciation costs
 Taxi1.60EUR/kmMost common fare per km
TaNetwork access time   
 Taxi service time5minAdded to the total journey time
 Waiting time in a bus stop7minAdded to the total journey time
 Walking time to a bus stop5minAdded to the total journey time
 Walking time from a bus stop to home or clinic5minAdded to the total journey time
FFare paid for the journey   
 One-way bus fare2.00, 3.80 or 5.00EURFare depends on the fare zone
 Taxi initial fixed charge5.90EURMost common fee in the study area
TinrPatient time loss associated with INR monitoring40minBlood test and the adjustment of warfarin dosage
CinrCost of the INR monitoring visit25.00EURIncludes healthcare personnel costs (result examination, warfarin dosage counseling via SMS or phone call and making the next appointment) based on the service provider prices for nurse/doctor phone consultation
CtCost of the INR blood test10.50EURSampling 7.50 € + test 3.00 €
CmCost of the medication   
 Warfarin3.90/2.20EUR/mo.Retail price (excl. VAT)/distributor’s price. Calculated with the average consumption of 5 mg/day
 Apixaban82.40/59.50EUR/mo.Retail price (excl. VAT)/distributor’s price
 Dabigatran82.40/59.50EUR/mo.Retail price (excl. VAT)/distributor’s price
 Rivaroxaban74.00/59.40EUR/mo.Retail price (excl. VAT)/distributor’s price
 Edoxaban73.80/59.40EUR/mo.Retail price (excl. VAT)/distributor’s price
  1. All monetary values, except the value of time, are based on the prices (EUR) on October 1, 2018