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Table 2 Parameters of the model

From: Modeling patients’ time, travel, and monitoring costs in anticoagulation management: societal savings achievable with the shift from warfarin to direct oral anticoagulants

Parameter

Description

Value

Unit

Additional information

T

Travel time using the fastest route on a road network

 

min

Calculated with network analysis

VOT

The value of time based on the average hourly income of a zip code area

 

EUR

Average hourly gross wage converted from the monthly gross wage in 2017

P

Patient’s productivity coefficient

1.00 or 0.35

Used as weight

Depicts patient’s lost contribution to the society. Working time is valued as 100% and leisure time as 35% of the hourly wage

Tp

Private car parking time

5

min

Added to the total journey time

D

Travel distance calculated from the fastest route on a road network

 

km

Calculated with network analysis

VOC

Vehicle operating cost

   
 

Private car

0.45

EUR/km

Includes fuel cost and vehicle maintenance and depreciation costs

 

Taxi

1.60

EUR/km

Most common fare per km

Ta

Network access time

   
 

Taxi service time

5

min

Added to the total journey time

 

Waiting time in a bus stop

7

min

Added to the total journey time

 

Walking time to a bus stop

5

min

Added to the total journey time

 

Walking time from a bus stop to home or clinic

5

min

Added to the total journey time

F

Fare paid for the journey

   
 

One-way bus fare

2.00, 3.80 or 5.00

EUR

Fare depends on the fare zone

 

Taxi initial fixed charge

5.90

EUR

Most common fee in the study area

Tinr

Patient time loss associated with INR monitoring

40

min

Blood test and the adjustment of warfarin dosage

Cinr

Cost of the INR monitoring visit

25.00

EUR

Includes healthcare personnel costs (result examination, warfarin dosage counseling via SMS or phone call and making the next appointment) based on the service provider prices for nurse/doctor phone consultation

Ct

Cost of the INR blood test

10.50

EUR

Sampling 7.50 € + test 3.00 €

Cm

Cost of the medication

   
 

Warfarin

3.90/2.20

EUR/mo.

Retail price (excl. VAT)/distributor’s price. Calculated with the average consumption of 5 mg/day

 

Apixaban

82.40/59.50

EUR/mo.

Retail price (excl. VAT)/distributor’s price

 

Dabigatran

82.40/59.50

EUR/mo.

Retail price (excl. VAT)/distributor’s price

 

Rivaroxaban

74.00/59.40

EUR/mo.

Retail price (excl. VAT)/distributor’s price

 

Edoxaban

73.80/59.40

EUR/mo.

Retail price (excl. VAT)/distributor’s price

  1. All monetary values, except the value of time, are based on the prices (EUR) on October 1, 2018