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Table 2 Simulation Parameters

From: Estimating the effectiveness and cost-effectiveness of establishing additional endovascular Thrombectomy stroke Centres in England: a discrete event simulation

ParameterMean and Uncertainty; distribution and parametersSource
Cost of EVT£9116 (£2519); gamma (554.86, 16.42)Balami [20]
Cost of Category A ambulance per minute£6.86PSSRU [18]
Survival (years) following stroke at 70
 mRS 0, median (IQR)8.4 (4.7,14.1)Estimated from results of
 mRS 1, median (IQR)7.9 (4.3, 13.2)DESa
 mRS 2, median (IQR)7.2 (3.8, 12.3) 
 mRS 3, median (IQR)3.7 (1.4, 7.0) 
 mRS 4, median (IQR)2.7 (0.92, 5.8) 
 mRS 5, median (IQR)1.3 (0.42, 3.6) 
 mRS 6, median (IQR)NA 
Utilities
 mRS 00.95, 0.08; beta (48.4, 2.55)MR CLEAN [22]
 mRS 10.93, 0.13; beta (128.04, 9.64) 
 mRS 20.83, 0.21; beta (222.24, 45.52) 
 mRS 30.62, 0.27; beta (173.70, 106.46) 
 mRS 40.42; 0.28; beta (173.15, 239.11) 
 mRS 50.11; 0.28; beta (6.07, 49.12) 
 mRS 60 
Cost Year 1
 mRS 0£6620Dewilde et al. [17]
 mRS 1£11,196 
 mRS 2£18,929 
 mRS 3£35,771 
 mRS 4£60,118 
 mRS 5£60,458 
 mRS 6£0 
Yearly Cost Thereafter
 mRS 0£2122Dewilde et al. [17]
 mRS 1£2836 
 mRS 2£4722 
 mRS 3£12,291 
 mRS 4£30,750 
 mRS 5£28,853 
 mRS 6£0 
Proportion all strokes presenting early with LAO & NIHSS ≥610.6% (SD 0.1%)McMeekin et al. [23]
Monthly probability of deteriorationb (increased mRS) before year 6 Rothwell et al. [10]
 00.006 
 10.004 
 20.002 
 30.001 
4,5As mortality 
  1. aEstimated from modelled mortality based on OXVASC, UK lifetables, Lothian Stroke Register
  2. bTwo or more point increase in mRS