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Table 2 Characteristics and findings of included studies

From: A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments

Care Location

Year

Country

Design

Intervention

Comparator

Number of participants

Uptake (%)

SVR (%)

Primary Care

        

Bloom

2017

Australia

Prospective cohort study of treatment uptake and SVR

Adherence to DAA treatment protocols

Treatment by tertiary care provider

1044

503 (40.6)

253 (50.2)

Francheville

2017

Canada

Prospective observational study design

Specialist nurse-led care

No comparator group

242

93 (38.4)

82 (88.2)

Kattakuzhy

2017

USA

Non-randomised open label study

Treatment by primary care providers (PCP) and nurse practitioners (NP)

Standard care - Treatment by secondary care clinic

NP 150 PCP 160

 

NP 134 (89.3) PCP139(86.9)

McCLure

2017

Australia

Retrospective data analysis of SVR12

Nurse-led care and GP remote consultation

Specialist care in Tertiary centre

Nurse-led 70

50 (74.3)

46 (65.7)

Miller

2016

USA

Retrospective observational study

Treatment by primary care providers

No comparator group

95

 

79 (83)

Norton

2017

USA

Retrospective cohort study of SVR

Treatment in urban primary care centre

SVR 12 in PWIDs and non_PWIDs

89

 

85(95.5)

Wade

2018

Australia

Randomised controlled trial

Testing, assessment and treatment in primary care

Testing, assessment and treatment in tertiary care

59

31 (52.5)

14 (23.7)

Integrated Health Systems (ECHO)

        

Abdulameer

2016

USA

Retrospective data analysis of SVR 12

VA-Echo model supporting primary care providers

No comparator group

588

 

318 (54)

Beste

2017

USA

Retrospective cohort study of treatment uptake and SVR

VA-Echo model supporting primary care providers

Standard care - Treatment by unexposed primary care providers

6431

1303 (21.4)

(58.2)

Buchanan

2015

United Kingdom

Retrospective data analysis

Community-based outreach clinic

Standard care - Treatment by secondary care clinic

77

24 (31.2)

 

Georgie

2016

USA

Retrospective data analysis of SVR12

VA-Echo model supporting primary care providers

Treatment by sub-specialist providers

623

 

Genotype 1 (GT1) (99) GT2 (98) GT3 (79)

Opioid Treatment Centres

        

Butner

2017

USA

Retrospective data analysis

Opioid treatment programme

No comparator group

75

75.0

64 (85.0)

Morris

2017

Australia

Retrospective data analysis of treatment uptake and SVR

Treatment in a community-based harm reduction and treatment facility

No comparator group

127

122 (96)

102 (80.3)

Read

2017

Australia

Retrospective data analysis of SVR12

Treatment of PWIDs in primary care setting

No comparator group

72

 

59 (81.9)

Pharmacies / Pharmacist Clinics

        

David

2017

USA

Retrospective data analysis of SVR12

Pharmacy-managed clinics

Treatment by non-pharmacist providers

204

 

(83.6)

Radley

2017

United Kingdom

Pilot cluster RCT of treatment uptake and SVR

Treatment in community Pharmacy

Treatment by secondary care clinic

26

3 (11.5)

3 (11.5)

Telemedicine

        

Cooper

2017

Canada

Retrospective cohort study of treatment uptake and SVR

Use of telemedicine

Treatment by secondary care clinic

157

35.0

18 (11.5)