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Table 3 Interrupted time-series analysis for originator molecules in the supplementary .list, using pricing data from 1999 to 2014 with 2004 as the interruption in the series. Statistically significant values (P < 0,05)

From: Evaluating the impact of the single exit price policy on a basket of originator medicines in South Africa from 1999 to 2014 using a time series analysis

INN   Trend (P value) Change in level (P value) Change in slope (P value) Constant (P value) Int 1 % Change in level 2004
Acyclovir 200 mg tabs 30, Zovirax 0,677 0,000 −0,429 0,422 −0,2 0,187 8551 0,000 11,936 −3,59
Carbamazepine 200 mg tabs 31, Tegretol 0,175 0,000 −0,477 0,001 −0,078 0,023 1464 0,000 2339 −20,39
Amox/Clav inj 600 mg (146,147)a 32, Augmentin 3,13 0,000 −9,99 0,001 −2211 0,006 7841 0,000 23,491 −42,53
Digoxin 0,25 mg tab 33, Lanoxin 0,021 0,000 −0,09 0,000 −0,014 0,001 0,206 0,000 0,311 −28,94
Fluconazole 200 mg cap (149, 150, 151)a 34, Diflucan −0,238 0,729 −6626 0,013 2738 0,004 50,703 0,000 49,513 −13,38
Ketoconazole 200 mg Tab (153)a 35, Nizoral 2079 0,000 −3,45 0,017 −1107 0,031 13,609 0,000 24,004 −14,37
Losartan 50 mg Tab (154, 155)a 36, Cozaar −0,017 0,948 − 0,096 0,911 − 0,276 0,381 5213 0,000 5128 −1,87
Phenytoin 100 mg caps (156)a 37, Epanutin 0,13 0,000 −0,43 0,000 −0,055 0,028 0,979 0,000 1629 −26,40
Rifampicin 150 mg caps (157)a 38, Rimactane 0,185 0,000 −0,555 0,000 −0,132 0,000 0,542 0,000 1467 −37,83
Rosuvastatin 10 mg Tabs (158, 159, 160)a 39, Crestor (no data) 0,239 0,000      4551 0,000 5746 0,00
Ofloxacin 200 mg Tabs (162)a 40, Tarivid 2128 0,000 −5167 0,000 −1113 0,004 10,353 0,000 20,993 −24,61
Aminophylline 250 mg inj 41, Aminophylline 2178 0,000 −7891 0,000 −0,944 0,040 16,003 0,000 26,893 −29,34
Miconazole Nitrate 2% crm (166)a 42, Daktarin 0,526 0,000 −0,971 0,001 −0,269 0,003 2,4 0,000 5,03 −19,30
Erythromycin 250 mg tabs 43, Erythrocin 0,329 0,323 0,7 0,611 −1915 0,004 4346 0,000 5991 11,68
Azithromycin 500 mg Tabs (169, 170, 171)a 44, Zithromax 2872 0,000 −10,698 0,000 −1595 0,017 27,625 0,000 41,985 −25,48
Cimetidine 200 mg tabs 45, Lenamet −0,22 0,000 −0,31 0,001 −0,238 0,000 1655 0,000 0,555 −55,86
Lisinopril 10 mg Tabs (175, 177)a 46, Zestril 0,187 0,231 −1,66 0,231 −0,217 0,186 2917 0,000 3852 −43,09
Loratadine 10 mg Tabs (178, 179, 180)a 47, Clarityne 0,249 0,267 − 1013 0,230 −0,667 0,012 5342 0,000 6587 −15,38
Ceftazidime I1g/vial inj (181, 182, 183)a 48, Fortum 10,593 0,000 −35,972 0,000 −7382 0,004 98,727 0,000 151,692 −23,71
Isosorbide Mononitrate 20mgT 49, Ismo 0,377 0,000 −1195 0,000 −0,255 0,000 1153 0,000 3038 −39,34
Thyroxine 50mcg Tab (185, 186)a 50, Eltroxin 0,034 0,001 −0,028 0,303 −0,004 0,614 0,333 0,000 0,503 −5,57
  1. Each item carries the® for trademark reference
  2. Crestor- no pre- date available
  3. anumber for molecules with no data in the list
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