Table 3 Interrupted time-series analysis for originator molecules in the supplementary .list, using pricing data from 1999 to 2014 with 2004 as the interruption in the series. Statistically significant values (P < 0,05)
INN | Trend | (P value) | Change in level | (P value) | Change in slope | (P value) | Constant | (P value) | Int 1 | % Change in level 2004 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Acyclovir 200 mg tabs | 30, Zovirax | 0,677 | 0,000 | −0,429 | 0,422 | −0,2 | 0,187 | 8551 | 0,000 | 11,936 | −3,59 |
Carbamazepine 200 mg tabs | 31, Tegretol | 0,175 | 0,000 | −0,477 | 0,001 | −0,078 | 0,023 | 1464 | 0,000 | 2339 | −20,39 |
Amox/Clav inj 600 mg (146,147)a | 32, Augmentin | 3,13 | 0,000 | −9,99 | 0,001 | −2211 | 0,006 | 7841 | 0,000 | 23,491 | −42,53 |
Digoxin 0,25 mg tab | 33, Lanoxin | 0,021 | 0,000 | −0,09 | 0,000 | −0,014 | 0,001 | 0,206 | 0,000 | 0,311 | −28,94 |
Fluconazole 200 mg cap (149, 150, 151)a | 34, Diflucan | −0,238 | 0,729 | −6626 | 0,013 | 2738 | 0,004 | 50,703 | 0,000 | 49,513 | −13,38 |
Ketoconazole 200 mg Tab (153)a | 35, Nizoral | 2079 | 0,000 | −3,45 | 0,017 | −1107 | 0,031 | 13,609 | 0,000 | 24,004 | −14,37 |
Losartan 50 mg Tab (154, 155)a | 36, Cozaar | −0,017 | 0,948 | − 0,096 | 0,911 | − 0,276 | 0,381 | 5213 | 0,000 | 5128 | −1,87 |
Phenytoin 100 mg caps (156)a | 37, Epanutin | 0,13 | 0,000 | −0,43 | 0,000 | −0,055 | 0,028 | 0,979 | 0,000 | 1629 | −26,40 |
Rifampicin 150 mg caps (157)a | 38, Rimactane | 0,185 | 0,000 | −0,555 | 0,000 | −0,132 | 0,000 | 0,542 | 0,000 | 1467 | −37,83 |
Rosuvastatin 10 mg Tabs (158, 159, 160)a | 39, Crestor (no data) | 0,239 | 0,000 | 4551 | 0,000 | 5746 | 0,00 | ||||
Ofloxacin 200 mg Tabs (162)a | 40, Tarivid | 2128 | 0,000 | −5167 | 0,000 | −1113 | 0,004 | 10,353 | 0,000 | 20,993 | −24,61 |
Aminophylline 250 mg inj | 41, Aminophylline | 2178 | 0,000 | −7891 | 0,000 | −0,944 | 0,040 | 16,003 | 0,000 | 26,893 | −29,34 |
Miconazole Nitrate 2% crm (166)a | 42, Daktarin | 0,526 | 0,000 | −0,971 | 0,001 | −0,269 | 0,003 | 2,4 | 0,000 | 5,03 | −19,30 |
Erythromycin 250 mg tabs | 43, Erythrocin | 0,329 | 0,323 | 0,7 | 0,611 | −1915 | 0,004 | 4346 | 0,000 | 5991 | 11,68 |
Azithromycin 500 mg Tabs (169, 170, 171)a | 44, Zithromax | 2872 | 0,000 | −10,698 | 0,000 | −1595 | 0,017 | 27,625 | 0,000 | 41,985 | −25,48 |
Cimetidine 200 mg tabs | 45, Lenamet | −0,22 | 0,000 | −0,31 | 0,001 | −0,238 | 0,000 | 1655 | 0,000 | 0,555 | −55,86 |
Lisinopril 10 mg Tabs (175, 177)a | 46, Zestril | 0,187 | 0,231 | −1,66 | 0,231 | −0,217 | 0,186 | 2917 | 0,000 | 3852 | −43,09 |
Loratadine 10 mg Tabs (178, 179, 180)a | 47, Clarityne | 0,249 | 0,267 | − 1013 | 0,230 | −0,667 | 0,012 | 5342 | 0,000 | 6587 | −15,38 |
Ceftazidime I1g/vial inj (181, 182, 183)a | 48, Fortum | 10,593 | 0,000 | −35,972 | 0,000 | −7382 | 0,004 | 98,727 | 0,000 | 151,692 | −23,71 |
Isosorbide Mononitrate 20mgT | 49, Ismo | 0,377 | 0,000 | −1195 | 0,000 | −0,255 | 0,000 | 1153 | 0,000 | 3038 | −39,34 |
Thyroxine 50mcg Tab (185, 186)a | 50, Eltroxin | 0,034 | 0,001 | −0,028 | 0,303 | −0,004 | 0,614 | 0,333 | 0,000 | 0,503 | −5,57 |