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Table 2 Interrupted time-series analysis for originator molecules in the regional core list, using pricing data from 1999 to 2014 with 2004 as the interruption in the series. Statistically significant values (P < 0,05)

From: Evaluating the impact of the single exit price policy on a basket of originator medicines in South Africa from 1999 to 2014 using a time series analysis

INN   Trend (P value) Change in level (P value) Change in slope (P value) Constant (P value) Int 1 % Change in level 2004
Albendazole 200 mg tabs 15, Zentela 0,571 0,002 −2812 0,000 0,740 0,001 12,272 0,000 15,127 −18,59
Amlodipine 5 mg Tabs (99,100,101)g 16, Norvasc 0,305 0,082 −2447 0,002 −0,201 0,254 4278 0,000 5803 −42,17
Atovastatin 20 mg Tabs (102,103,104)g 17, Lipitor 0,349 0,001 −2645 0,000 −0,114 0,170 7665 0,000 9,41 −28,11
Beclomethasone100mcg/dose inh 18, Becotideb −17,698 0,035 − 6847 0,809 18,412 0,269 164,637 0,000 76,147 −8,99
Cephalexin 250 mg caps 19, Keflexc 0,78 0,004 −7919 0,000 −0,752 0,093 5665 0,000 9565 −82,79
Enalapril 10 mg tabs 20, Renitec −0,56 0,000 0,159 0,589 0,573 0,000 3859 0,000 1059 15,01
Fluoxetine 20 mg tabs 21, Prozac 0,579 0,000 −2787 0,000 −0,324 0,001 6021 0,000 8916 −31,26
Gliclazide 80 mg tabs 22, Diamicrond 0,093 0,004 −0,311 0,010 −0,055 0,084 0,873 0,000 1338 −23,24
Hydrochlorothiazide 25 mg tabs 23, Dichloridee 0,031 0,178      0,742 0,009 0,897 0,00
Ibuprofen 200 mg tabs 24, Brufenf 0,034 0,000 −0,103 0,000 −0,019 0,006 0,419 0,000 0,589 −17,49
Metformin 500 mg tabs 25, Glucophage −0,021 0,027 −0,2 0,000 0,038 0,001 0,606 0,000 0,501 −39,92
Metronidazole 200 mg tabs 26, Flagyl 0,195 0,000 −0,609 0,000 −0,125 0,000 0,721 0,000 1696 −35,91
Nifedipine Retard 10 mg tab 27, Adalat Ret 0,324 0,000 −0,632 0,003 −0,147 0,016 1788 0,000 3408 −18,54
Ranitidine 150 mg tabs 28, Zantac 0,333 0,005 −0,101 0,777 0,024 0,824 4038 0,000 5703 −1,77
Sodium Valproate200mg Tab 29, Epilim 0,151 0,000 −0,307 0,016 −0,035 0,292 1344 0,000 2099 −14,63
  1. Withdrawn a 2010 b 2006 c2006 d 2009 e2001 f 2009
  2. Each item carries the® for trademark reference
  3. gnumber for molecules with no data in the list
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