Table 1 Interrupted time-series analysis for originator molecules in the global core list, using pricing data from 1999 to 2014 with 2004 as the interruption in the series (P < 0,05)
INN | Trend | (P value) | Change in level | (P value) | Change in slope | (P value) | Constant | (P value) | Int 1 | % Change in level 2004 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Salbutamol 2 mg/5mls Syr | 1, Ventolin | 0,018 | 0,000 | −0,065 | 0,000 | −0,014 | 0,000 | 0,19 | 0,000 | 0,28 | −23,47 |
Glibenclamide 5 mg tab | 2, Daonil | 0,228 | 0,000 | −0,771 | 0,001 | −0,047 | 0,382 | 2,45 | 0,000 | 3,59 | −21,51 |
Atenolol 50 mg caps | 3, Tenormin | 0,427 | 0,000 | −1242 | 0,000 | −0,209 | 0,007 | 2,56 | 0,000 | 4,70 | −26,45 |
Captopril 25 mg tabs | 4, Capotena | 0,044 | 0,014 | −0,117 | 0,071 | 0,016 | 0,365 | 2,09 | 0,000 | 2,31 | −5,07 |
Simvastatin 20 mg tabs | 5, Zocor | −0,997 | 0,001 | − 1078 | 0,225 | 0,832 | 0,004 | 9,56 | 0,000 | 4,58 | −23,54 |
Amitriptyline 25 mg tabs | 6, Tryptanol | 0,176 | 0,000 | −0,397 | 0,000 | −0,169 | 0,000 | 1,70 | 0,000 | 2,58 | −15,42 |
Ciprofloxacin 500 mg tabs | 7, Ciprobay | −1028 | 0,002 | −5113 | 0,000 | 1560 | 0,000 | 18,21 | 0,000 | 13,07 | −39,12 |
Co-Trimoxazole 8 + 40 mg/ml syr | 8, Bactrim | 0,364 | 0,000 | −2267 | 0,000 | −0,247 | 0,000 | 2,46 | 0,000 | 4,28 | −52,94 |
Amoxicillin 500 mg caps | 9, Amoxilb | 0,334 | 0,000 | −0,127 | 0,429 | −0,274 | 0,001 | 3,52 | 0,000 | 5,19 | −2,45 |
Ceftriaxone 1 g/vial inj | 10, Rocephin | 4302 | 0,081 | −82,503 | 0,000 | −3371 | 0,237 | 121,81 | 0,000 | 143,32 | −57,57 |
Diazepam 5 mg | 11, Valium | 0,318 | 0,000 | −0,772 | 0,000 | −0,213 | 0,000 | 1,00 | 0,000 | 2,59 | −29,83 |
Diclofenac 50 mg tabs | 12, Voltaren | 0,063 | 0,013 | −0,209 | 0,025 | 0,021 | 0,373 | 1,16 | 0,000 | 1,48 | −14,17 |
Paracetamol 25 mg/ml syr | 13, Panado | 0,001 | 0,702 | −0,030 | 0,017 | 0,014 | 0,000 | 0,18 | 0,000 | 0,18 | −16,57 |
Omeprazole 20 mg tabs | 14, Losec | −0,610 | 0,036 | 1183 | 0,245 | 1298 | 0,000 | 11,58 | 0,000 | 8,53 | 13,87 |