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Table 1 Interrupted time-series analysis for originator molecules in the global core list, using pricing data from 1999 to 2014 with 2004 as the interruption in the series (P < 0,05)

From: Evaluating the impact of the single exit price policy on a basket of originator medicines in South Africa from 1999 to 2014 using a time series analysis

INN   Trend (P value) Change in level (P value) Change in slope (P value) Constant (P value) Int 1 % Change in level 2004
Salbutamol 2 mg/5mls Syr 1, Ventolin 0,018 0,000 −0,065 0,000 −0,014 0,000 0,19 0,000 0,28 −23,47
Glibenclamide 5 mg tab 2, Daonil 0,228 0,000 −0,771 0,001 −0,047 0,382 2,45 0,000 3,59 −21,51
Atenolol 50 mg caps 3, Tenormin 0,427 0,000 −1242 0,000 −0,209 0,007 2,56 0,000 4,70 −26,45
Captopril 25 mg tabs 4, Capotena 0,044 0,014 −0,117 0,071 0,016 0,365 2,09 0,000 2,31 −5,07
Simvastatin 20 mg tabs 5, Zocor −0,997 0,001 − 1078 0,225 0,832 0,004 9,56 0,000 4,58 −23,54
Amitriptyline 25 mg tabs 6, Tryptanol 0,176 0,000 −0,397 0,000 −0,169 0,000 1,70 0,000 2,58 −15,42
Ciprofloxacin 500 mg tabs 7, Ciprobay −1028 0,002 −5113 0,000 1560 0,000 18,21 0,000 13,07 −39,12
Co-Trimoxazole 8 + 40 mg/ml syr 8, Bactrim 0,364 0,000 −2267 0,000 −0,247 0,000 2,46 0,000 4,28 −52,94
Amoxicillin 500 mg caps 9, Amoxilb 0,334 0,000 −0,127 0,429 −0,274 0,001 3,52 0,000 5,19 −2,45
Ceftriaxone 1 g/vial inj 10, Rocephin 4302 0,081 −82,503 0,000 −3371 0,237 121,81 0,000 143,32 −57,57
Diazepam 5 mg 11, Valium 0,318 0,000 −0,772 0,000 −0,213 0,000 1,00 0,000 2,59 −29,83
Diclofenac 50 mg tabs 12, Voltaren 0,063 0,013 −0,209 0,025 0,021 0,373 1,16 0,000 1,48 −14,17
Paracetamol 25 mg/ml syr 13, Panado 0,001 0,702 −0,030 0,017 0,014 0,000 0,18 0,000 0,18 −16,57
Omeprazole 20 mg tabs 14, Losec −0,610 0,036 1183 0,245 1298 0,000 11,58 0,000 8,53 13,87
  1. Withdrawn- a2009 b 2008
  2. Each item carries the® for trademark reference
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