Table 5 PRIMEtime CE mediation factors, exposure parameters, outcomes, and modelled uncertainty distributions. Adapted and updated from Cobiac et al.[32]
Mediation factors | ||||||
|---|---|---|---|---|---|---|
Parameter | Exposure parameters | Outcomes | Unit of change | Distribution of uncertainty range | Change in value of outcome (SE) | Notes |
 Ischaemic stroke mediation | BMI (kg/m2) | Systolic blood pressure (mmHg) [74] |  | Normal | 0.65 (0.04) |  |
Fruit intake (g/day) | Systolic blood pressure (mmHg) [74] | Â | Normal | 0.42 (0.17 | Â | |
Vegetable intake (g/day) | Systolic blood pressure (mmHg) [74] | Â | Normal | 0.54 (0.2) | Â | |
Fruit intake (g/day) | Total cholesterol (mmol/L) [74] | Â | Normal | 0.027 (0.017) | Â | |
Vegetable intake (g/day) | Total cholesterol (mmol/L) [74] | Â | Normal | 0.047 (0.026) | Â | |
 Ischaemic heart disease mediation | BMI (kg/m2) | Systolic blood pressure (mmHg) [74] |  | Normal | 0.31 (0.016) |  |
Fruit intake (g/day) | Systolic blood pressure (mmHg) [74] | Â | Normal | 0.39 (0.15) | Â | |
Vegetable intake (g/day) | Systolic blood pressure (mmHg) [74] | Â | Normal | 0.47 (0.21) | Â | |
Fruit intake (g/day) | Total cholesterol (mmol/L) [74] | Â | Normal | 0.008 (0.0057) | Â | |
Vegetable intake (g/day) | Total cholesterol (mmol/L) [74] | Â | Normal | 0.012 (0.01) | Â | |