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Table 5 PRIMEtime CE mediation factors, exposure parameters, outcomes, and modelled uncertainty distributions. Adapted and updated from Cobiac et al.[32]

From: PRIMEtime CE: a multistate life table model for estimating the cost-effectiveness of interventions affecting diet and physical activity

Mediation factors
Parameter Exposure parameters Outcomes Unit of change Distribution of uncertainty range Change in value of outcome (SE) Notes
 Ischaemic stroke mediation BMI (kg/m2) Systolic blood pressure (mmHg) [74]   Normal 0.65 (0.04)  
Fruit intake (g/day) Systolic blood pressure (mmHg) [74]   Normal 0.42 (0.17  
Vegetable intake (g/day) Systolic blood pressure (mmHg) [74]   Normal 0.54 (0.2)  
Fruit intake (g/day) Total cholesterol (mmol/L) [74]   Normal 0.027 (0.017)  
Vegetable intake (g/day) Total cholesterol (mmol/L) [74]   Normal 0.047 (0.026)  
 Ischaemic heart disease mediation BMI (kg/m2) Systolic blood pressure (mmHg) [74]   Normal 0.31 (0.016)  
Fruit intake (g/day) Systolic blood pressure (mmHg) [74]   Normal 0.39 (0.15)  
Vegetable intake (g/day) Systolic blood pressure (mmHg) [74]   Normal 0.47 (0.21)  
Fruit intake (g/day) Total cholesterol (mmol/L) [74]   Normal 0.008 (0.0057)  
Vegetable intake (g/day) Total cholesterol (mmol/L) [74]   Normal 0.012 (0.01)  
  1. SD standard deviation, NDNS National Diet and Nutrition Survey, CHD coronary heart disease, BMI body mass index, MET Metabolic Equivalent of Task