Table 2 Observed mean (SD) at baseline, 6 months and 12 months. Estimated differences (95% Confidence Interval (CI)) within groups from baseline to 6 months and from baseline to 12 months, and differences between groups at 12 months

63.9 (13.2)

67.7 (14.5)

66.7 (14.3)

4.0 (0.4 to 7.5)

0.027

3.1 (−0.4 to 6.5)

0.084

4.0 (− 0.6 to 8.6)

0.085

63.0 (12.9)

64.9 (12.4)

62.2 (10.0)

1.4 (−2.2 to 5.0)

0.445

−1.0 (−4.5 to 2.6)

0.587

18.2 (6.5)

17.4 (7.4)

17.4 (6.8)

−0.8 (− 2.4 to 0.8)

0.320

− 0.5 (− 1.8 to 0.9)

0.486

0.6 (− 1.3 to 2.4)

0.526

18.8 (5.6)

18.1 (6.6)

17.4 (6.1)

−0.5 (−2.1 to 1.1)

0.550

−1.1 (−2.5 to 0.3)

0.124

29.2 (14.0)

27.9 (16.0)

25.9 (14.5)

−1.6 (−5.2 to 2.0)

0.379

−3.3 (−6.7 to 0.1)

0.061

−2.6 (−7.3 to 2.0)

0.269

32.6 (13.1)

30.8 (15.0)

31.0 (15.0)

−0.5 (−4.3 to 3.2)

0.779

−0.6 (− 4.2 to 2.9)

0.728

3.4 (3.3)

4.0 (2.8)

6.3 (14.5)

0.6 (−0.2 to 1.4)

0.134

2.9 (0.5 to 5.2)

0.017

2.9 (−0.1 to 5.8)

0.055

3.5 (2.9)

3.4 (2.9)

3.4 (2.9)

−0.1 (−0.9 to 0.8)

0.894

−0.003 (−2.4 to 2.4)

0.998

62.7 (18.2)

53.9 (21.5)

55.5 (23.6)

−8.7 (−14.2 to −3.3)

0.002

−7.0 (− 12.5 to − 1.4)

0.014

−0.5 (− 7.6 to 6.7)

0.901

62.8 (15.1)

56.1 (19.3)

56.0 (19.6)

−6.5 (−12.1 to − 1.0)

0.021

−6.5 (− 12.2 to −0.8)

0.026

4.4 (3.0)

4.8 (3.9)

4.8 (3.5)

0.4 (−0.4 to 1.1)

0.329

0.3 (−0.5 to 1.0)

0.468

0.3 (−0.7 to 1.3)

0.525

5.1 (3.1)

5.1 (3.7)

5.0 (3.6)

0.2 (−0.6 to 1.0)

0.672

−0.1 (− 0.8 to 0.7)

0.883

7.8 (3.4)

7.1 (4.5)

7.2 (4.3)

−0.7 (−1.4 to 0.002)

0.051

−0.6 (− 1.3 to 0.2)

0.132

0.1 (− 0.9 to 1.2)

0.798

8.1 (3.6)

7.8 (3.7)

7.5 (3.1)

−0.5 (−1.3 to 0.2)

0.163

−0.7 (−1.5 to 0.1)

0.072

38.1 (10.5)

39.1 (12.8)

39.1 (12.1)

1.0 (−1.5 to 3.3)

0.452

0.5 (−1.9 to 3.0)

0.678

1.5 (−1.9 to 4.9)

0.387

37.5 (10.4)

37.6 (10.8)

37.2 (11.2)

−0.7 (−3.2 to 1.7)

0.554

−1.0 (−3.5 to 1.6)

0.453

61.4 (12.4)

62.8 (15.2)

63.4 (15.5)

1.1 (−1.4 to 3.5)

0.401

1.1 (−1.4 to 3.5)

0.393

0.5 (−2.9 to 3.9)

0.771

61.8 (13.0)

63.7 (12.9)

62.1 (12.4)

1.5 (−1.0 to 4.0)

0.231

0.6 (−1.9 to 3.0)

0.657

0.63 (0.14)

0.64 (0.16)

0.63 (0.15)

0.02 (−0.01 to 0.05)

0.174

0.002 (− 0.03 to 0.03)

0.896

− 0.03 (− 0.1 to 0.01)

0.206

0.61 (0.14)

0.65 (0.14)

0.64 (0.16)

0.04 (0.004 to 0.07)

0.029

0.03 (−0.002 to 0.06)

0.069

46.3 (21.3)

51.8 (19.1)

45.1 (16.6)

6.5 (0.9 to 12.1)

0.023

0.2 (−5.8 to 6.1)

0.960

1.7 (−5.6 to 8.9)

0.649

43.4 (18.5)

45.5 (16.2)

43.3 (16.4)

0.8 (−5.0 to 6.5)

0.797

−1.5 (−7.7 to 4.6)

0.625

2.1 (0.89)

3.5 (0.9)

3.6 (0.9)

1.4 (1.1 to 1.6)

< 0.001

1.4 (1.2 to 1.7)

< 0.001

−0.1 (−0.4 to 0.2)

0.363

2.2 (0.69)

3.6 (0.7)

3.8 (0.6)

1.4 (1.1 to 1.7)

< 0.001

1.6 (1.3 to 1.8)

< 0.001

4.0 (0.87)

4.0 (1.0)

4.0 (0.9)

−0.002 (−0.2 to 0.2)

0.985

0.01 (−0.2 to 0.2)

0.927

0.01 (−0.3 to 0.3)

0.929

4.0 (1.02)

4.1 (0.8)

4.0 (0.8)

0.1 (−0.1 to 0.3)

0.356

−0.003 (− 0.2 to 0.2)

0.976

12.5 (4.1)

13.3 (6.6)

15.0 (4.7)

0.9 (−0.4 to 2.2)

0.161

2.2 (1.4 to 3.1)

< 0.001

−0.5 (−1.7 to 0.7)

0.383

11.5 (4.0)

12.8 (5.6)

14.4 (3.7)

1.0 (−0.4 to 2.3)

0.153

2.8 (1.9 to 3.6)

< 0.001