Table 5 Differences between therapeutic classes regarding the frequency of the “Not for Generic Substitution” mention use
Therapeutic class | NGS mention use | ||||
|---|---|---|---|---|---|
Never (0%) | Rarely (1–24%) | Sometimes (25–49%) | Often (50–74%) | Very often/always (75–100%) | |
Thyroid hormones – n, % | 21 (7.6) | 30 (10.8) | 30 (10.8) | 62 (22.4) | 134 (48.4) |
Antiepileptic drugs – n, % | 31 (11.2) | 51 (18.4) | 48 (17.3) | 68 (24.6) | 79 (28.5) |
Antiplatelet agents – n, % | 45 (16.2) | 110 (39.7) | 40 (14.4) | 60 (21.7) | 22 (7.9) |
Proton pump inhibitors – n, % | 74 (26.7) | 117 (42.2) | 40 (14.4) | 38 (13.7) | 8 (2.9) |
Neuroleptics – n, % | 95 (34.3) | 107 (38.6) | 44 (15.9) | 25 (9.0) | 6 (2.2) |
Oral antidiabetic drugs– n, % | 85 (30.7) | 115 (41.5) | 48 (17.3) | 23 (8.3) | 6 (2.2) |
Statins – n, % | 88 (31.8) | 124 (44.8) | 38 (13.7) | 22 (7.9) | 5 (1.8) |
Antidepressants – n, % | 74 (26.7) | 117 (42.2) | 57 (20.6) | 25 (9.0) | 4 (1.4) |
Hypnotic drugs – n, % | 80 (28.9) | 125 (45.1) | 40 (14.4) | 29 (10.5) | 3 (1.1) |
Angiotensin converting enzyme inhibitors/Angiotensin II receptor blockers – n, % | 81 (29.2) | 120 (43.3) | 48 (17.3) | 25 (9.0) | 3 (1.1) |
Step II-III analgesics – n, % | 106 (38.3) | 109 (39.4) | 47 (17.0) | 12 (4.3) | 3 (1.1) |
Diuretics – n, % | 106 (38.3) | 123 (44.4) | 31 (11.2) | 15 (5.4) | 2 (0.7) |
Antispasmodic drugs – n, % | 139 (50.2) | 96 (34.7) | 30 (10.8) | 10 (3.6) | 2 (0.7) |
Anti-inflammatory drugs (Nonsteroidal and steroidal) – n, % | 118 (42.6) | 108 (39.0) | 40 (14.4) | 9 (3.2) | 2 (0.7) |
Beta blockers – n, % | 88 (31.8) | 128 (46.2) | 36 (13.0) | 24 (8.7) | 1 (0.4) |
Antibiotics – n, % | 107 (38.6) | 108 (39.0) | 39 (14.1) | 22 (7.9) | 1 (0.4) |
Step I analgesics – n, % | 138 (49.8) | 100 (36.1) | 25 (9.0) | 13 (4.7) | 1 (0.4) |
Oral contraceptives – n, % | 116 (41.9) | 114 (41.2) | 34 (12.3) | 13 (4.7) | 0 (0.0) |