Drug Class | Drug | Frequency (No/%) | Degree of interaction | Effect on INR |
---|---|---|---|---|
Anti-infective Agents | Metronidazole | 16 (25) | Major | ↑ |
 | TMP/SMX | 9 (14) | Major | ↑ |
 | Fluconazole | 4 (6) | Major | ↑ |
 | Levofloxacin | 3 (5) | Major | ↑ |
 | Ciprofloxacin | 1 (2) | Major | ↑ |
 | Clarithromycin | 1 (2) | Major | ↑ |
 | Ceftriaxone | 34 (54) | Moderate | ↑ |
 | Amoxicillin/clavulanate | 10 (16) | Moderate | ↑ |
 | Azithromycin | 9 (14) | Moderate | ↑ |
 | Doxycycline | 7 (11) | Moderate | ↑ |
ARVs | Efavirenz | 3 (5) | Moderate | ↑/↓ |
 | Nevirapine | 1 (2) | Moderate | ↓ |
Anti-TBs | Isoniazid | 5 (8) | Moderate | ↑ |
 | Rifampicin | 5 (8) | Major | ↓ |
Anti-ulcer drugs | Esomeprazole | 26 (41) | Moderate | ↑ |
 | Omeprazole | 7 (11) | Moderate | ↑ |
Analgesics | Diclofenac | 5 (8) | Major | – |
 | Tramadol | 21 (33) | Moderate | ↑ |
 | Paracetamol | 20 (32) | Moderate? | ↑ |
 | Celecoxib | 1 (2) | Moderate | – |
CNS drugs | Carbamazepine | 2 (3) | Moderate | ↓ |
 | Phenytoin | 4 (6) | Moderate | ↑/↓ |
 | Fluoxetine | 2 (3) | Moderate | ↑ |
Glucocorticoids | Prednisone | 4 (6) | Moderate | ↑/↓ |
 | Dexamethasone | 1 (2) | Moderate | ↑/↓ |
 | Hydrocortisone | 1 (2) | Moderate | ↑/↓ |
Diuretics | Furosemide | 26 (41) | Minor | ↑ |
 | Spironolactone | 12 (19) | Minor | ↓ |
CVS drugs | Amiodarone | 16 (25) | Major | ↑ |