Table 1 Assumption used to develop the base case analysis
Assumption | References |
|---|---|
The target population is represented by patients with severe haemophilia A | Product indication |
The use of rFVIIIFc is considered only for prophylaxis treatment | Product indication |
Product consumption related to the use of drugs for surgery is not included in the analysis because no difference between the two scenario are hypothesized | Assumption based on the opinion of clinical experts |
Patients with inhibitors are excluded from the analysis because deserving particular treatment different from those analysed in the present analysis | Product indication |
Paediatric patients are exposed only to prophylaxis regimen, no on-demand treatment is considered for these patient according to current clinical practice in Italy | Assumption based on the opinion of clinical experts |
According to current clinical practice in Italy, paediatric patients are not exposed to treatment with plasma derived products | Assumption based on the opinion of clinical experts |
Age cut-off to differentiate treatment for paediatric and adults patients is considered equal to 12Â years old | Assumption based on the opinion of clinical experts, [7] |
An equal treatment schedule is considered for both plasma derived and conventional recombinant products | Assumption based on the opinion of clinical experts |
The incidence of spontaneous bleeding is equal between patients treated with plasma derived and conventional recombinant products | Assumption based on the opinion of clinical experts |
The consumption of products for the management of spontaneous bleeding is equal between patients treated with plasma derived and conventional recombinant products | Assumption based on the opinion of clinical experts |
For all products compliance with prophylaxis treatment is considered to be 100% | Assumption based on the opinion of clinical experts |
Percentage of patients switching to rFVIIIFc is considered to do not differ among the diverse products | Assumption based on the opinion of clinical experts |