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Table 2 Number of DDDs/1000 inhabitants/day of analgesics during the pre-withdrawal period (Jan-June 2009) and the post-withdrawal period (Jan-June 2012)

From: Use of analgesics in France, following dextropropoxyphene withdrawal

 

Pre-withdrawal

Post-withdrawal

Percentage changes

WHO ladder step 1

 NSAIDs

29,41

26,53

−9,8%

 PC

30,79

39,16

+ 27,2%

 ALL STEP 1

60,20

65,69

+ 9,1%

WHO ladder step 2

 DXP / PC

28,82

0,00

−100%

 CODEINE

0,03

0,05

+ 50,0%

 CODEINE / PC

3,04

5,06

+ 66,3%

 OPIUM / PC

1,40

2,55

+ 83,0%

 TRAMADOL

3,58

3,99

+ 11,3%

 TRAMADOL / PC

9,68

13,39

+ 38,3%

 ALL STEP 2

46,56

25,05

−46,2%

WHO ladder step 3

 MORPHINE-LIKE DRUGS

1,90

2,50

+ 31,3%

 MORPHINE

0,79

0,84

+ 5,5%

 ALL STEP 3

2,70

3,33

+ 23,7%

 ALL ANALGESICS

109,45

94,07

−14,1%