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Table 3 Hospitalizations and outpatient visits during first-line and second-line therapy

From: Health care resource use among patients with advanced non-small cell lung cancer: the PIvOTAL retrospective observational study

First-line therapy

Italy

Spain

Germany

Australia

Japanc

Korea

Taiwan

Brazil

(N = 174)

(N = 202)

(N = 139)

(N = 208)

(N = 175)

(N = 150)

(N = 217)

(N = 175)

Admitted to hospital or hospice, n

36

55

61

83

109

83

94

33

 Hospitalization

36 (100)

54 (98)

61 (100)

82 (99)

109 (100)

83 (100)

93 (99)

33 (100)

 Hospice

0

2 (4)

0

6 (7)

0

0

1 (1)

0

Total no. hospitalizationsa

75

112

140

284

242

251

200

42

 No. hospitalizations per patient, median (range)

1 (1–7)

2 (0–7)

2 (1–7)

2 (0–34)

2 (1–10)

2 (1–10)

1 (0–9)

1 (1–3)

Total days of hospitalization per patient, mean (SD)

12.7 (14.1)

17.9 (17.0)

20.6 (29.2)

16.1 (24.4)

42.5 (28.5)

21.3 (29.1)

19.0 (19.3)

21.8 (26.5)

 Median (range)

8 (1–77)

13 (1–100)

9 (1–160)

9 (1–199)

36 (3–146)

12 (1–178)

14 (2–139)

10 (1–90)

LOS per hospitalization (days)b

 Mean (SD)

6.1 (7.8)

8.7 (5.8)

9.0 (11.3)

4.6 (5.7)

19.1 (15.3)

7.1 (9.5)

8.9 (11.2)

17.0 (21.0)

 Median (range)

4 (1–50)

7 (1–28)

4 (1–32)

3 (1–48)

15 (1–81)

3 (1–47)

5 (1–71)

7 (1–77)

No. hospitalizations per 100 pt-wk

1.53

1.81

3.00

4.83

5.49

6.70

2.27

1.03

Total no. emergency visits

6

153

5

73

9

64

125

64

No. emergency visits per 100 pt-wk

0.12

2.47

0.11

1.24

0.20

1.71

1.42

1.57

Patients with OP visits, n

143

119

56

177

117

130

149

94

OP visits, mean (SD)

7.6 (6.9)

9.0 (9.5)

8.7 (9.8)

11.5 (12.7)

14.2 (16.6)

10.6 (10.5)

14.0 (15.3)

7.0 (7.1)

 OP visits, median (range)

5 (1–35)

7 (1–58)

4 (1–41)

7 (1–105)

9 (1–124)

8 (1–58)

10 (1–109)

5 (1–36)

No. OP visits per 100 pt-wk

22.02

17.33

10.43

34.74

37.65

36.94

23.57

16.24

Second-line therapy

N = 101

N = 96

N = 64

N = 128

N = 105

N = 96

N = 155

N = 91

Admitted to hospital or hospice, n

9

24

23

37

39

41

62

17

 Hospitalization

9 (100)

24 (100)

23 (100)

36 (97)

39 (100)

40 (98)

62 (100)

17 (100)

 Hospice

0

1 (4)

0

2 (5)

0

2 (5)

0

0

Total no. hospitalizationsa

13

47

39

87

77

78

161

22

 No. hospitalizations per patient, median (range)

1 (1–3)

1 (1–6)

1 (1–5)

1 (0–13)

1 (1–7)

1 (0–8)

2 (1–9)

1 (1–2)

Total days of hospitalization per patient, mean (SD)

10.3 (6.4)

20.1 (23.0)

14.5 (14.5)

13.4 (12.0)

42.3 (26.4)

14.6 (13.1)

20.3 (20.4)

11.6 (9.3)

 Median (range)

9 (3–21)

11 (2–88)

8 (1–49)

10 (2–54)

40 (3–108)

11 (1–56)

13 (2–104)

8 (2–30)

LOS per hospitalization (days)b

 Mean (SD)

7.2 (4.6)

10.5 (5.3)

8.5 (9.5)

5.5 (6.2)

21.7 (15.6)

7.5 (8.5)

7.8 (9.9)

9.0 (7.4)

 Median (range)

8 (1–15)

10 (2–19)

5 (1–32)

4 (1–44)

17 (3–74)

5 (1–56)

4 (1–69)

7 (2–30)

No. hospitalizations per 100 pt-wk

0.60

3.57

2.76

3.63

5.13

3.93

3.47

1.59

Total no. emergency visits

6

52

0

30

6

41

82

25

No. emergency visits per 100 pt-wk

0.28

3.95

0

1.25

0.40

2.07

1.77

1.81

Patients with OP visits, n

72

50

28

96

60

79

90

40

OP visits, mean (SD)

6.9 (7.3)

6.1 (4.2)

5.3 (6.0)

7.3 (6.1)

9.6 (10.0)

9.1 (10.5)

15.4 (17.7)

4.2 (3.9)

 OP visits, median (range)

4 (1–41)

6 (1–17)

3 (1–30)

5 (1–26)

5 (1–49)

5 (1–49)

10 (1–92)

3 (1–18)

No. OP visits per 100 pt-wk

23.00

23.26

10.40

29.08

38.23

36.29

29.79

12.18

  1. aHospitalizations did not include hospice stays
  2. bFor length of stay (LOS), extreme values at the upper end of the distribution were truncated at the 99th percentile of the study population
  3. cSome of the hospitalization, emergency visit, and OP visit data for Japan have been previously reported by Isobe et al. [14]
  4. LOS length of stay in days, No. number of, OP outpatient, pt-wk patient-weeks
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