Simulation modeling for stratified breast cancer screening – a systematic review of cost and quality of life assumptions

Arnold, Matthias

doi:10.1186/s12913-017-2766-2

Table 2 Phases of care delivery and input parameters

From: Simulation modeling for stratified breast cancer screening – a systematic review of cost and quality of life assumptions

Cluster	Study	Study perspective	Risk assessment		Detection (screening)		Diagnostic work up		Treatment
	Study	Study perspective	Cost	Utility	Cost	Utility	Cost	Utility	Cost	Utility
Screening in general population	[12]	Provider/Payer			✓ Charges		✓ Charges	✓ Assumption	✓ Charges	✓ EQ-5D S
	[16]	Provider/Payer			✓ Charges	✓ TTO expert	✓ Charges	✓ TTO expert	✓ Cost	✓ EQ-5D A
	[14]	Provider/Payer			✓ Charges	✓ TTO expert	✓ Charges	✓ TTO expert	✓ Cost	✓ EQ-5D A
	[17]	Not mentioned			✓ Charges	✓ TTO expert	✓ Charges	✓ TTO expert	✓ Cost	✓ EQ-5D A
	[15]	Societal and Provider/Payer			✓ Charges		✓ Charges		✓ Charges	✓ EQ-5D A
	[13]	Provider/Payer			✓ Cost		✓ Cost	✓ Assumption	✓ Cost	✓ EQ-5D S
Screening in high risk population	[19]	Societal			✓ Charges		✓ Charges		✓ Charges	✓ Expert VAS
	[22]	Not mentioned			✓ Charges	✓ Not described	✓ Charges	✓ Not described	✓ Cost	✓ Not described
	[21]	Provider/Payer			✓ Charges	✓ Not described	✓ Charges	✓ Not described	✓ Charges	✓ Not described
	[23]	Provider/Payer			✓ Cost		✓ Cost		✓ Cost	✓ TTO patient
	[24]	Societal			✓ Charges	✓ Assumption	✓ Charges	✓ Assumption	✓ Cost	✓ EQ-5D A
	[25]	Provider/Payer			✓ Charges	✓ Assumption	✓ Charges	✓ VAS - SG	✓ Charges	✓ SG patient
	[20]	Provider/Payer			✓ Cost	✓ Assumption	✓ Cost	✓ VAS - SG	✓ Charges	✓ SG patient
	[26]	Societal			✓ Charges	✓ Assumption	✓ Charges	✓ Assumption	✓ Charges	✓ Assumption
	[27]	Provider/Payer			✓ Charges		✓ Charges		✓ Charges	✓ Assumption
Screening after risk assessment	[31]	Not mentioned	✓ Charges		✓ Charges		✓ Charges		✓ Charges	✓ EQ-5D A
	[29]	Not mentioned	✓ Cost		✓ Charges				✓ Charges	✓ Assumption
	[28]	Not mentioned	✓ Cost						✓ Cost	✓ Mix

✓ indicates studies that included the respective phase in their cost or utility framework
EQ-5D S refers EQ-5D health utilities using an English tariff [56] in a Swedish population [49]
TTO expert describe expert interviews using a time-trade-off method to extract health utilities [36]
EQ-5D A refers EQ-5D health utilities using a tariff based on assumptions for disutility from breast cancer and a time-trade-off estimate for healthy individuals in an American population [50]
Expert VAS refers to visual analogue scale health utilities based on expert interviews [36]
VAS – SG refers to VAS health utilities in American women enrolled in mammography screening [57] which were transformed to represent standard gamble values
TTO patients refers to time-trade-off study with patients in the UK [58]
SG patient refers to standard gamble health utilities estimated in an American patient population [59]
Mix describes that the authors used a mean value of a selection of time-trade-off, standard gamble and rating scales [28]

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