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Table 2 List of determinants to vaccine coverage

From: Determinants of effective vaccine coverage in low and middle-income countries: a systematic review and interpretive synthesis

Theme

Determinant

Description

Relationship

Evidence

Label in Fig. 2

Facility Readiness

Facility Readiness (Routine)

Health facility is ready to vaccinate children

Directly impacts Utilization

[44]

1

Service HR/Mgmt

Adequate health facility staff to meet demand

Directly impacts Facility Readiness

[11, 18, 31, 43,44,45,46,47,48,49,50,51,52]

2

Training

Adequate health facility staff training

Moderates Service HR/Mgmt

[18, 27, 44, 49, 50, 51,52,53,54,55,56,57,58]

3

Performance Assessment

Procedures for facility staff performance assessment

Moderates Service HR/Mgmt

[11, 18, 54, 59, 60]

4

Disbursement/Fund Mgmt

Adequate resources and management for health facility staff

Directly impacts Service HR/Mgmt, Training, Performance Assessment

[18, 31, 44, 49]

5

Waste Disposal

Procedures and equipment for vaccine waste

Directly impacts Facility Readiness

[36, 54]

6

Facility Vaccine Supply

Health facility has vaccines to administer

Directly impacts Facility Readiness

[44, 48, 49,50,51,52, 55,56,57,58, 60, 61]

7

Facility Storage Capacity

Health facility has sufficient capacity in refrigerators and freezers to store vaccines

Moderates Facility Vaccine Supply

[44, 50, 52, 61,62,63,64]

8

Stock/Flow Awareness

Staff members know the status of vaccine inventory

Moderates Facility Vaccine Supply

[50, 52]

9

Consumption Forecasting

Appropriate anticipation of future demand

Directly impacts Stock/Flow Awareness

[18, 47]

10

Transaction Visibility

Adequate resources dedicated to supply chain transparency

Directly impacts Stock/Flow Awareness

[50, 52]

11

Transaction Reporting

Adequate resources dedicated to communication of transactions

Directly impacts Stock/Flow Awareness

[50, 52]

12

Supply LMIS

Logistics management information system for tracking supply

Moderates Transaction Reporting, Transaction Visibility

[50, 52]

13

Inventory HR/Mgmt

Adequate resources dedicated to inventory management

Directly impacts Stock/Flow Awareness

[5, 18, 50])

14

Training

Adequate inventory management training

Moderates Inventory HR/Mgmt

[18, 27, 44, 49, 50, 51,52,53,54,55,56,57,58]

15

Performance Assessment

Procedures for inventory management performance assessment

Moderates Inventory HR/Mgmt

[11, 18, 54, 59, 60]

16

Disbursement/Fund Mgmt

Adequate resources and management for inventory management

Directly impacts Inventory HR/Mgmt, Training, Performance Assessment

[18, 31, 44, 49]

17

Intermediary Vaccine Supply

Intermediate storage facility has vaccines to distribute

Directly impacts Facility Vaccine Supply

[31, 47, 60]

18

Intermediary Storage Capacity

Intermediate storage facility has sufficient capacity in refrigerators and freezers to store vaccines

Moderates Intermediary Vaccine Supply

[31, 47, 60]

19

Facility Distribution Method

Established means of transporting stock from intermediate storage to health facility

Directly impacts Facility Vaccine Supply

[31, 47, 60]

20

Distribution Equipment

Vehicles and other equipment to distribute supply from intermediate storage to health facility

Moderates Facility Distribution Method

[31, 47, 60]

21

Distribution HR/Mgmt

Adequate resources dedicated to distribution management

Moderates Facility Vaccine Supply, Intermediary Vaccine Supply

[31, 44, 52]

22

Training

Adequate distribution management training

Moderates Distribution HR/Mgmt

[18, 27, 44, 50, 51,52,53,54,55,56,57,58]

23

Performance Assessment

Procedures for distribution system performance assessment

Moderates Distribution HR/Mgmt

[11, 18, 54, 59, 60]

24

Disbursement/Fund Mgmt

Adequate resources and management for distribution systems

Directly impacts Distribution HR/Mgmt, Training, Performance Assessment

[18, 31, 44, 49]

25

Country Vaccine Supply

Central storage facility has vaccines to distribute

Directly impacts Intermediary Vaccine Supply

[18, 44, 50, 52, 65]

26

Country Storage Capacity

Central storage facility has sufficient capacity in refrigerators and freezers to store vaccines

Moderates Country Vaccine Supply

[18, 44, 50, 52, 65]

27

Intermediary Distribution Method

Established means of transporting stock from central to intermediate storage

Directly impacts Intermediary Vaccine Supply

[31, 47, 60]

28

Distribution Equipment

Vehicles and other equipment to distribute supply from central to intermediate storage

Moderates Intermediary Distribution Method

[31, 47, 60]

29

Leadership and Consistency

Oversight and decision-making in vaccine systems

Directly impacts Disbursement/Fund Mgmt, Outreach Protocol, Demand Generation Activities, Community Partnership, Service Cost, Supply LMIS

[8, 31, 44, 49, 66]

30

Political Commitment

High-level support for vaccination systems

Directly impacts Leadership and Consistency, Funding

[11, 18, 37, 38, 49, 65, 67]

31

Development Partner Participation

High-level engagement from development partners in vaccination systems

Directly Impacts Political Commitment, Funding, Country Vaccine Supply

[11, 18]

32

Funding

Adequate high-level funding for vaccination systems

Directly impacts Disbursement/Fund Mgmt, Facility Infrastructure, Service Cost

[18, 31, 44, 49]

33

Facility Readiness (Outreach)

Health facility is ready to vaccinate children through outreach activities

Directly impacts Utilization

[7, 9, 10, 18, 27, 31, 49, 51, 53]

34

Outreach Transportation

Adequate vehicles to conduct outreach activities

Directly impacts Facility Readiness (Outreach)

[18, 31]

35

Mobile Storage Capacity

Health facility has sufficient capacity to store vaccines during outreach activities

Directly impacts Facility Readiness (Outreach)

[31]

36

Outreach Protocol

Procedures and plans for outreach activities

Directly impacts Mobile Storage Capacity, Outreach Transportation

[10, 60]

37

Decision to Vaccinate

Community Partnership

Active and positive relationship between health facility and community

Directly impacts Quality of Care, Community Awareness, Attitude

[10, 11, 27, 31, 37, 49, 56, 66, 67,68,69,70]

38

Demand Generation Activities

Health facility encourages vaccine utilization in the community

Directly impacts Perceived Safety, Need, Effectiveness, Community Awareness, Attitude, Vaccine Awareness, Attitude

[8, 18, 31, 44, 56, 69, 71]

39

Quality of Care

Quality of care at health facility for vaccination

Directly impacts Wait Time, Perceived Quality of Care

[30, 44, 50]

40

Facility Infrastructure

Quality of health facility building and equipment

Directly impacts Wait Time, Perceived Quality of Care

[41, 44, 47, 53, 57]

41

Service Cost

Cost of vaccine services charged to the mother or caretaker by the health facility

Moderates Ability to Finance Service

[8, 10, 30, 37, 41, 68, 72]

42

Wait Time

Wait time at health facility for vaccination

Directly impacts Perceived Quality of Care

[8, 9, 27, 30, 45, 48, 54, 68, 72,73,74,75]

43

Patient Volume

Number of patients who typically visit health facility

Directly impacts Wait Time

[9]

44

Decision to Vaccinate

Mother or caretaker intends to vaccinate the child

Directly impacts Utilization

[8, 36, 41, 76]

45

Vaccine Awareness, Attitude

Mother or caretaker is aware of vaccine and perceives it to be beneficial

Directly impacts Decision to Vaccinate, Perceived Eligibility

[8, 28,29,30, 32, 41, 46, 48, 49, 51, 53, 54, 56, 59, 61, 65, 69, 72,73,74, 77,78,79,80,81,82,83]

46

Perceived Quality of Care

Mother or caretaker perceptions about the quality of care in the health facility

Directly impacts Vaccine Awareness, Attitude

[8, 9, 61, 83]

47

Education

Mother or caretaker education

Directly impacts Vaccine Awareness, Attitude

[8–10, 32, 37, 39, 44, 48, 51, 57, 59, 61, 66, 75, 76, 78, 81,82,83,84,85,86,87,88,89]

48

Prior Use

Child has been vaccinated previously

Directly impacts Vaccine Awareness, Attitude, Child Has Card

[8, 57, 66]

49

Child Has Card

Child has vaccine card for recording doses

Directly impacts Vaccine Awareness, Attitude

[10, 32, 54, 72, 73, 79, 81]

50

Perceived Safety, Need, Effectiveness

Mother or caretaker perceives that there is risk of disease and the vaccine is safe and effective

Directly impacts Vaccine Awareness, Attitude

[9, 29, 30, 38, 41, 45, 46, 51, 68, 72, 73, 75, 76,77,78,79, 90, 91]

51

Community Awareness, Attitude

Influential community members are aware of the vaccine and perceive it to be beneficial

Directly impacts Vaccine Awareness, Attitude, Perceived Safety, Need, Effectiveness, Patient Volume

[10, 27, 37, 57, 71]

52

Perceived Eligibility

Mother or caretaker perceives that child is eligible for vaccination

Directly impacts Decision to Vaccinate

[30, 57, 73, 77]

53

Child Eligibility

Child Eligibility

Child meets criteria to be eligible for vaccination

Directly impacts Utilization

[9, 48, 67, 70, 77, 78, 84, 92]

54

Child Health

Child is healthy enough to be vaccinated

Directly impacts Child Eligibility, Perceived Eligibility

[7, 9, 29, 38, 45, 46, 48, 54, 57, 71, 72, 79, 90]

55

Child Age

Child is of the appropriate age to be vaccinated

Directly impacts Child Eligibility, Perceived Eligibility

[9, 48, 67, 71, 77, 78, 84, 92]

56

Child Sex

Sex of child

Directly impacts Perceived Eligibility

[9, 38, 39, 48, 51, 59, 61, 65, 67, 88]

57

Mother Able

Mother Able

Mother or caretaker has access to the means and time to vaccinate the child

Directly impacts Utilization

[9, 10, 41, 48, 50, 57, 75]

58

Ability to Finance Service

Mother or caretaker can afford any cost of vaccine services

Directly impacts Mother Able, Decision to Vaccinate

[28, 45, 54, 68]

59

Ability to Finance Transport

Mother or caretaker can afford any cost of transportation

Directly impacts Mother Able, Decision to Vaccinate

[10, 30, 41, 48, 68]

60

Ability to Spare Time

Mother or caretaker can take time out of other responsibilities to vaccinate the child

Directly impacts Mother Able, Decision to Vaccinate

[9, 10, 28, 30, 46, 48, 57, 59, 61, 72, 73]

61

Insurance

Whether the mother or caretaker has health insurance

Moderates Ability to Finance Service

[8, 9, 41, 75]

62

SES

Socio-economic status of mother or caretaker

Directly impacts Ability to Finance Service

[10, 32, 37, 57, 67, 85, 88]

63

Transport Time/Cost

Duration and cost of transportation to health facility incurred by mother or caretaker

Moderates Ability to Finance Transport, Ability to Spare Time

[10, 30, 41, 48, 68]

64

Parity

Number of siblings of the child

Directly impacts Ability to Spare Time

[8–10, 29, 30, 39, 51, 57, 59, 61, 71, 75, 76, 79, 81, 83, 85, 88, 93]

65

Distance

Distance from household to health facility

Directly impacts Transport Time/Cost

[10, 27, 30, 32, 39, 45, 48, 54, 56, 57, 61, 65, 79, 88, 93]

66

Marital Status

Mother or caretaker marital status

Directly impacts Ability to Spare Time

[9, 39, 48, 57, 59, 75, 76, 78, 83, 87]

67

Maternal Health

Mother or caretaker health

Directly impacts Mother Able, Decision to Vaccinate

[9, 45, 46, 48, 57]

68