Table 5 Summary of risk of bias of included studies for non randomised trials, controlled before after studies, interrupted time series, and historically controlled trials (1=strong, 2=moderate, 3=weak, -=Not applicable)

Brenner et al, (2011) [92]

1

1

3

2

1

-

2

Chandir et al, (2010) [83]

2

2

1

2

-

3

2

Fatugase et al, (2013) [58]

2

2

1

3

2

1

2

Finocchario-Kessler et al, (2014) [37]

1

3

1

2

-

1

2

Galasso et al, [35]

2

3

3

2

1

3

3

Kundu et al, (2012) [85]

1

3

3

2

1

1

3

McCollum et al, (2012) [34]

2

2

3

2

-

1

2

Oche et al, (2011) [67]

1

2

3

2

-

1

2

Ridde et al, (2013) [93]

2

2

3

2

-

3

2

Robinson et al, (2001) [46]

3

2

3

2

-

-

3

Ryman et al, (2011) [47]

2

2

3

2

-

-

2

Schwartz et al, (2004) [52]

2

2

3

2

-

-

3

Simonyanm et al, (2013) [42]

1

2

1

2

-

1

1