Parameter | Variation | Cost / QALY | Incremental cost per QALY gained (€), Bedaquiline | |||||
---|---|---|---|---|---|---|---|---|
BR alone | Linezolid plus BR | Delamanid plus BR | Bedaquiline plus BR | Versus BR alone | Versus Linezolid plus BR | Versus Delamanid plus BR | ||
Base case | 60,962 / 3.68 | 80,460 / 3.91 | 81,079 / 4.21 | 85,575 / 4.79 | 22,238 | 5787 | 7774 | |
BR SCC rates at 6-months | +20% (37.2% SCC to 44.6%) | 58,648 / 4.00 | 78,179 / 4.24 | 78,192 / 4.58 | 82,170 / 5.17 | 20,105 | 4316 | 6713 |
−20%(37.2% SCC to 29.7%) | 63,037 / 3.36 | 82,518 / 3.56 | 83,807 / 3.82 | 89,010 / 4.35 | 26,384 | 8196 | 9802 | |
Effect of bedaquiline on SCC rates | +20% | 60,962 / 3.68 | 80,460 / 3.91 | 81,079 / 4.21 | 84,384 / 5.01 | 17,711 | 3569 | 4162 |
−20% | 60,962 / 3.68 | 80,460 / 3.91 | 81,079 / 4.21 | 86,986 / 4.52 | 30,960 | 10,565 | 18,921 | |
Maximum duration of linezolid treatment | 42 to 24Â weeks (duration of Bedaquiline treatment) | 60,962 / 3.68 | 73,307 / 3.88 | 81,079 / 4.21 | 85,575 / 4.79 | 22,238 | 13,553 | 7774 |
Relapse after cure | +20% | 61,232 / 3.65 | 80,732 / 3.87 | 81,421 / 4.16 | 85,716 / 4.77 | 21,809 | 5508 | 7092 |
−20% | 60,684 / 3.72 | 80,180 / 3.95 | 80,729 / 4.26 | 85,433 / 4.81 | 22,701 | 6094 | 8552 | |
Utility weight for no cure | plus20% | 60,962 / 3.95 | 80,460 / 4.16 | 81,079 / 4.46 | 85,575 / 5.02 | 22,988 | 5983 | 8056 |
−20% | 60,962 / 3.48 | 80,460 / 3.72 | 81,079 / 4.04 | 85,575 / 4.66 | 20,973 | 5465 | 7337 | |
Utility for cure | Perfect health after cure | 60,962 / 4.26 | 80,460 / 4.53 | 81,079 / 4.89 | 85,575 / 5.57 | 18,770 | 4905 | 6596 |
Discount rate | 0% cost 3% outcomes | 62,032 / 3.68 | 81,524 / 3.91 | 82,098 / 4.21 | 86,538 / 4.79 | 22,141 | 5672 | 7676 |
6% costs 3% outcomes | 60,039 / 3.68 | 79,547 / 3.91 | 80,210 / 4.21 | 84,765 / 4.79 | 22,340 | 5903 | 7875 | |
3% costs 0% outcomes | 60,962 / 4.12 | 80,460 / 4.38 | 81,079 / 4.73 | 85,575 / 5.4 | 19,224 | 5015 | 6712 | |
3% costs 6% outcomes | 60,962 / 3.33 | 80,460 / 3.52 | 81,079 / 3.79 | 85,575 / 4.29 | 25,473 | 6611 | 8914 | |
Cost for BR medication | +20% | 66,824 / 3.68 | 86,271 / 3.91 | 86,831 / 4.21 | 91,177 / 4.79 | 22,003 | 5550 | 7514 |
−20% | 55,099 / 3.68 | 74,649 / 3.91 | 75,327 / 4.21 | 79,974 / 4.79 | 22,474 | 6024 | 8034 | |
Cost for AE’s | +20% | 60,962 / 3.68 | 80,484 / 3.91 | 81,079 / 4.21 | 85,579 / 4.79 | 22,242 | 5764 | 7779 |
−20% | 60,962 / 3.68 | 80,436 / 3.91 | 81,078 / 4.21 | 85,572 / 4.79 | 22,235 | 5811 | 7768 |