Cost-effectiveness of adding novel or group 5 interventions to a background regimen for the treatment of multidrug-resistant tuberculosis in Germany

Table 1 Transition probabilities in the model

Health state	Transition to	Monthly probability (%)	Distribution for probabilistic analysis	Source
Active TB (MDR-TB; secondary MDR-TB and XDR-TB)	Sputum culture converted	Variable	Multivariate log-normal distribution	[14]
	Lost to follow-up	0.39	Beta	[14]
	Death	MDR-TB, no cure: 2.21, MDR-TB, cured: 0.32 XDR-TB, no cure: 2.69% XDR-TB, cured: 0.39	Beta	[21, 22]
Lost to follow-up	Death	6.87	Beta	[24]
Sputum culture converted	Active secondary MDR-TB (relapse)	0.98	Beta	[14]
Sputum culture converted	MDR-TB or active XDR-TB (relapse)	(21.4 to XDR-TB; 78.6 to MDR-TB)	Beta	[14]
Treatment completion and cured	Active secondary MDR-TB (reoccurrence)	0.20	Beta	[21]
Treatment completion and cured	MDR-TB or active XDR-TB (reoccurrence)	(21.4 to XDR-TB; 78.6 to MDR-TB)	Beta	[14]

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