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Table 5 Mean and median adherence rates and proportion with adherence ≥0.80 for patients on polytherapy (n = 777)

From: Measuring medication adherence in patients with incident hypertension: a retrospective cohort study

 

Range

Mean (SD)

Median (IQR)

Proportion ≥0.80

Overall

MPRi

Low

0.01–1.00

0.47 (0.32)

0.41 (0.16, 0.77)

24.1%

High

0.15–1.00

0.84 (0.21)

0.93 (0.74, 0.99)

69.6%

Sum

0.25–1.00

0.95 (0.13)

1.00 (1.00, 1.00)

90.5%

Mean

0.11–1.00

0.66 (0.23)

0.64 (0.49, 0.87)

33.7%

MPRp

Low

0.05–1.00

0.84 (0.21)

0.92 (0.77, 0.99)

71.2%

High

0.10–1.00

0.94 (0.13)

1.00 (0.94, 1.00)

89.5%

Sum

0.16–1.00

0.96 (0.12)

1.00 (1.00, 1.00)

92.7%

Mean

0.10–1.00

0.89 (0.15)

0.95 (0.84, 0.99)

81.0%

PDC

 

0.15–1.00

0.90 (0.18)

0.98 (0.90, 1.00)

83.0%

Age

65 to 74 years

MPRi

Low

0.01–1.00

0.50 (0.32)

0.48 (0.19, 0.82)

25.2%

High

0.16–1.00

0.85 (0.19)

0.92 (0.79, 0.99)

73.5%

Sum

0.33–1.00

0.97 (0.11)

1.00 (1.00, 1.00)

93.2%

Mean

0.11–1.00

0.67 (0.23)

0.69 (0.49, 0.88)

37.2%

MPRp

Low

0.05–1.00

0.83 (0.22)

0.91 (0.78, 0.98)

71.8%

High

0.10–1.00

0.93 (0.15)

1.00 (0.94, 1.00)

89.7%

Sum

0.20–1.00

0.96 (0.12)

1.00 (1.00, 1.00)

92.7%

Mean

0.10–1.00

0.88 (0.17)

0.94 (0.84, 0.99)

82.5%

PDC

0.16–1.00

0.91 (0.16)

0.98 (0.91, 1.00)

85.9%

75 years and over

MPRi

Low

0.01–1.00

0.46 (0.33)

0.39 (0.16, 0.76)

23.6%

High

0.15–1.00

0.83 (0.21)

0.94 (0.74, 0.99)

68.0%

Sum

0.25–1.00

0.95 (0.14)

1.00 (1.00, 1.00)

89.3%

Mean

0.11–1.00

0.65 (0.23)

0.63 (0.48, 0.87)

32.2%

MPRp

Low

0.08–1.00

0.84 (0.21)

0.93 (0.77, 0.99)

70.9%

High

0.20–1.00

0.94 (0.12)

1.00 (0.94, 1.00)

89.4%

Sum

0.16–1.00

0.96 (0.11)

1.00 (1.00, 1.00)

92.6%

Mean

0.15–1.00

0.89 (0.15)

0.96 (0.85, 0.99)

80.3%

PDC

0.15–1.00

0.89 (0.19)

0.99 (0.88, 1.00)

81.8%

Sex

Male

MPRi

Low

0.01–1.00

0.50 (0.33)

0.44 (0.16, 0.82)

26.2%

High

0.15–1.00

0.83 (0.22)

0.93 (0.74, 0.99)

69.2%

Sum

0.25–1.00

0.94 (0.15)

1.00 (1.00, 1.00)

89.1%

Mean

0.11–1.00

0.66 (0.24)

0.67 (0.48, 0.88)

36.6%

MPRp

Low

0.05–1.00

0.83 (0.22)

0.92 (0.78, 0.98)

70.5%

High

0.18–1.00

0.93 (0.14)

0.99 (0.93, 1.0)

90.8%

Sum

0.16–1.00

0.96 (0.13)

1.00 (1.00, 1.00)

91.9%

Mean

0.15–1.00

0.88 (0.16)

0.95 (0.84, 0.99)

80.9%

PDC

0.15–1.00

0.88 (0.20)

0.98 (0.85, 1.00)

80.4%

Female

MPRi

Low

0.01–1.00

0.45 (0.32)

0.38 (0.16, 0.74)

22.3%

High

0.16–1.00

0.84 (0.19)

0.94 (0.75, 0.99)

70.0%

Sum

0.33–1.00

0.96 (0.12)

1.00 (1.00, 1.00)

91.6%

Mean

0.11–1.00

0.65 (0.22)

0.63 (0.49, 0.86)

31.4%

MPRp

Low

0.10–1.00

0.84 (0.20)

0.93 (0.77, 0.99)

71.7%

High

0.10–1.00

0.94 (0.13)

1.00 (0.95, 1.00)

88.5%

Sum

0.20–1.00

0.97 (0.10)

1.00 (1.00, 1.00)

93.3%

Mean

0.10–1.00

0.89 (0.15)

0.95 (0.85, 0.99)

81.0%

PDC

0.16–1.00

0.91 (0.16)

0.99 (0.91, 1.00)

85.1%

Income

Lowest quintile

MPRi

Low

0.01–1.00

0.47 (0.31)

0.42 (0.16, 0.75)

20.1%

High

0.16–1.00

0.83 (0.21)

0.93 (0.74, 0.99)

66.9%

Sum

0.33–1.00

0.95 (0.14)

1.00 (1.00, 1.00)

90.7%

Mean

0. 11–1.00

0.65 (0.23)

0.63 (0.46, 0.86)

35.3%

MPRp

Low

0.10–1.00

0.79 (0.24)

0.89 (0.68, 0.99)

61.6%

High

0.10–1.00

0.92 (0.16)

1.00 (0.91, 1.00)

85.5%

Sum

0.16–1.00

0.94 (0.15)

1.00 (1.00, 1.00)

88.5%

Mean

0.10–1.00

0.86 (0.18)

0.92 (0.80, 0.99)

74.6%

PDC

0.16–1.00

0.88 (0.19)

0.98 (0.84, 1.00)

79.1%

Highest quintile

MPRi

Low

0.01–1.00

0.47 (0.32)

0.40 (0.16, 0.79)

24.6%

High

0.19–1.00

0.83 (0.20)

0.93 (0.69, 0.99)

67.5%

Sum

0.36–1.00

0.95 (0.12)

1.00 (1.00, 1.00)

90.5%

Mean

0. 12–1.00

0.65 (0.23)

0.63 (0.49, 0.88)

31.8%

MPRp

Low

0.14–1.00

0.87 (0.17)

0.94 (0.81, 0.99)

77.6%

High

0.42–1.00

0.94 (0.11)

1.00 (0.95, 1.00)

92.0%

Sum

0.35–1.00

0.96 (0.11)

1.00 (1.00, 1.00)

92.9%

Mean

0.31–1.00

0.91 (0.13)

0.96 (0.87, 0.99)

86.4%

PDC

0.19–1.00

0.91 (0.17)

0.99 (0.92, 0.99)

86.5%

Charlson comorbidities

0 or 1 comorbidities

MPRi

Low

0.01–1.00

0.46 (0.32)

0.41 (0.16, 0.76)

23.1%

High

0.15–1.00

0.83 (0.21)

0.93 (0.74, 0.99)

69.1%

Sum

0.25–1.00

0.95 (0.14)

1.00 (1.00, 1.00)

90.2%

Mean

0.11–1.00

0.65 (0.23)

0.63 (0.48, 0.87)

32.3%

MPRp

Low

0.05–1.00

0.83 (0.21)

0.92 (0.77, 0.99)

71.1%

High

0.10–1.00

0.94 (0.13)

1.00 (0.94, 1.00)

89.5%

Sum

0.16–1.00

0.96 (0.12)

1.00 (1.00, 1.00)

92.7%

Mean

0.10–1.00

0.89 (0.16)

0.95 (0.84, 0.99)

80.5%

PDC

0.15–1.00

0.90 (0.18)

0.98 (0.90, 1.00)

83.1%

2+ comorbidities

MPRi

Low

0.05–1.00

0.54 (0.34)

0.57 (0.16, 0.85)

33.3%

 

High

0.25–1.00

0.86 (0.19)

0.96 (0.80, 1.00)

74.7%

 

Sum

0.41–1.00

0.97 (0.10)

1.00 (1.00, 1.00)

93.3%

 

Mean

0.11–1.00

0.71 (0.24)

0.76 (0.51, 0.92)

46.7%

MPRp

Low

0.08–1.00

0.85 (0.19)

0.93 (0.75, 0.99)

72.0%

High

0.48–1.00

0.94 (0.12)

1.00 (0.96, 1.00)

89.3%

Sum

0.53–1.00

0.97 (0.09)

1.00 (1.00, 1.00)

92.0%

Mean

0.36–1.00

0.90 (0.13)

0.95 (0.85, 0.99)

85.3%

PDC

0.25–1.00

0.91 (0.15)

0.99 (0.88, 1.00)

82.7%

  1. Abbreviations: SD standard deviation, IQR interquartile range, MPRi interval based medication possession ratio, MPRp prescription based medication possession ratio, PDC proportion of days covered