Table 2 Methods of handling use of multiple concurrent anti-hypertensive medications when measuring adherence in hypertension literature
From: Measuring medication adherence in patients with incident hypertension: a retrospective cohort study
Measure | Method of handling concurrent medications | Method considers adherence to any medication versus adherence to each medication |
|---|---|---|
Sum of the total number of gap days (days the patient did not possess the medication) for each anti-hypertensive medication divided by the sum of the total number of days the patient was prescribed each anti-hypertensive medication [24, 26] | Any | |
Calculate and report CMG for each anti-hypertensive medication class [26] | Each | |
Calculate CMG for each anti-hypertensive medication class, then take the mean CMG for each patient [25] | Each | |
CSA [25] | Calculate CSA for each anti-hypertensive medication class, then take the mean CSA for each patient [25] | Each |
Exclude patients not on monotherapy [28] | N/A | |
Method of handling polytherapy not reported [33] | N/A | |
Calculate and report for each class of anti-hypertensive medication [27, 30] | Each | |
Take the single medication with the maximum number of days supply over one year period and use this single medication for the MPR estimate for the patient [35] | Each | |
Calculate MPR for each anti-hypertensive mediation class, then take the lowest MPR (for the medication with lowest adherence) as the MPR estimate for each patient [34, 39] | Each | |
Calculate MPR for each anti-hypertensive medication class, then take the mean MPR for each patient [25, 29, 32, 34] | Each | |
Include all days where at least one anti-hypertensive medication was available in the numerator of the ratio of number of days with medication to days in study period [13] | Any | |
Calculate numerator for MPR by taking sum of all days supply of all anti-hypertensive medications prescribed as the numerator [40] | Any | |
Include only days where all anti-hypertensive medications of interest were available [31] | Each | |
Include all days where at least one anti-hypertensive medication was available in the numerator of the ratio of number of days with medication to days in study period [36, 37] | Any | |
MedsIndex [33] | Method of handling polytherapy not reported [33] | N/A |