Table 2 Costs and utilities used in the economic model

 GP appointment

£37

PSSRU [40]

 Annual review

£397

NAO [41]

 Opportunistic screening for depression

£2

Assumption

 Antidepressants (daily costs)

£0.073

Tosh et al. [16]

 IAPT per session

£88

Tosh et al. [16]

 Diabetes — no complications

£252

Clarke et al. [32]

 CHF — year of event / subsequent years

£3,559 / £1,01

Clarke et al. [32]

 IHD — year of event / subsequent years

£3,139 / £790

Clarke et al. [32]

 MI — year of event / subsequent years

£6,522 / £744

Clarke et al. [32]

 Stroke — year of event / subsequent years

£3,793 / £399

Clarke et al. [32]

 Blindness — year of event / subsequent years

£1,397 / £450

Clarke et al. [32]

 Ulcer — year of event / subsequent years

£1,855 / £21

Ghatnekar et al. [42]

 Amputation — year of event / subsequent years

£13,556 / £481

Clarke et al. [32]

 Renal failure — year of event / subsequent years

£34,806 / £34,806

NICE STA for dapagliflozin [43]

 Severe hypoglycaemia

£390

NICE STA for dapagliflozin [43]

Health state utilities

Value

References

Baseline

0.807

Alva et al. [27]

 MI (year before)

−0.065

Alva et al. [27]

 MI (prior history)

0.008

Alva et al. [27]

 IHD

−0.028

Alva et al. [27]

 Stroke

−0.165

Alva et al. [27]

 Heart Failure

−0.101

Alva et al. [27]

 Amputation

−0.172

Alva et al. [27]

 Blindness

0.033

Alva et al. [27]

 Renal failure

−0.263

Klarenbach et al. [29]

 Foot ulcer

−0.016

Sollie et al. [28]

 Severe Hypoglycaemia

−0.00186

Marrett et al. [30]

 Minor depression

0

Kaltenthaler et al. [31]

 Major depression

−0.3

Kaltenthaler et al. [31]

 Effect of being on depression treatment on the decrement for major depression; responders only (multiplier)

x0.5

Assumption