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Table 3 Total and incremental results (bedaquiline plus BR versus BR) in the high burden countries analyzed

From: Health outcomes of bedaquiline in the treatment of multidrug-resistant tuberculosis in selected high burden countries

 

Estonia

Russia

South Africa

Peru

China

Philippines

India

Cohort

 Populationa, cases (n)

38

6,537

6,494

564

826

11

20,763

Estimated Total DALYs, avoided

 Bedaquiline + BR

438.41

72,824.26

78,816.95

8,318.51

7,329.94

152.50

299,598.12

 BR only

554.29

90,479.07

96,530.04

10,475.26

9,792.45

177.64

384,990.40

Estimated DALYs per patient, avoided

 Bedaquiline + BR

11.54

11.14

12.14

14.75

8.87

13.86

14.43

 BR only

14.59

13.84

14.86

18.57

11.86

16.15

18.54

 Incremental change in DALYs (bedaquiline + BR vs. BR) (%, relative to bedaquiline)

-20.90

-19.51

-18.35

-20.59

-25.15

-14.16

-22.18

Patients with successful outcomes (%)

 Bedaquiline + BR

40.66

38.67

36.50

40.09

47.25

28.69

42.76

 BR only

26.29

24.83

23.55

25.88

31.16

17.85

27.97

 Incremental change in successful outcomes (bedaquiline + BR vs. BR) (%, relative to bedaquiline)

+54.67

+55.78

+55.02

+54.87

+51.62

+60.78

+52.87

Number of cases of acquired resistance

 Bedaquiline + BR

2.16

349.72

28.20

31.88

52.90

0.50

1,274.00

 BR only

3.16

512.37

47.58

46.63

77.04

0.73

1,862.89

 Incremental change in acquired resistance (bedaquiline + BR vs. BR) (%, relative to bedaquiline)

-31.59

-31.75

-40.8

-31.62

-31.34

-32.22

-31.61

  1. BR background regimen, DALY disability-adjusted life years
  2. aPopulation cohort: Russia, China, Philippines: New lab-confirmed MDR-TB cases in 2012 [31]; South Africa: Total number of patients started on MDR-TB treatment in 2012 [31]; Estonia, Peru: laboratory-confirmed MDR-TB cases in 2012 [31]; India: Total number of patients started on MDR-TB treatment in 2013 [2]