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Table 1 Characteristics of the 696 patients and additional financial support after reaching the height limit

From: Effects of financial support on treatment of adolescents with growth hormone deficiency: a retrospective study in Japan

Variables

Ineligible

Eligiblea

p valueb

(n = 588)

(n = 108)

GH treatment, n (%)

 Stopped

282 (48.0)

26 (24.1)

<0.001

 Continued

306 (52.0)

82 (75.9)

 

Sex, n (%)

 Girls

196 (33.3)

49 (45.4)

0.016

 Boys

392 (66.7)

59 (54.6)

 

Age, y

 Mean (SD)

14.8 (1.4)

14.4 (1.3)

0.0015

 Girls

13.7 (1.0)

13.7 (1.0)

0.62

 Boys

15.4 (1.2)

15.0 (1.1)

0.017

Height SDS

 Median

−1.59

−1.525

0.16

 (Interquartile range)

(−1.89 to −1.21)

(−1.81 to −1.07)

Growth velocity, cm/y

 Mean (SD)

6.7 (2.9)

6.5 (2.5)

0.46

Bone age, y

(n = 520)

(n = 100)

 

 Mean (SD)

13.1 (1.4)

12.9 (1.2)

0.13

 Girls

12.1 (1.1)

12.2 (1.0)

0.82

 Boys

13.6 (1.3)

13.6 (0.9)

0.56

Puberty status, n (%)

(n = 562)

(n = 108)

 

 Pre-puberty

68 (12.1)

17 (15.7)

0.30

 Post-puberty

494 (87.9)

91 (84.3)

 

Adverse effects, n (%)

 

 No

560 (95.2)

105 (97.2)

0.46

 Yes

28 (4.8)

3 (2.8)

 

When patients reached height limit, n (%)

 Before October 2009

437 (74.3)

9 (8.3)

<0.001

 October 2009 and after

151 (25.7)

99 (91.7)

 
  1. GH growth hormone, SD standard deviation, SDS standard deviation score
  2. aEligible for at least one of the national or local programs of financial support after the child exceeded the height limit defined by the Medical Aid Program for Chronic Pediatric Disease of Specified Categories
  3. bChi-square tests, two-tailed t-tests, Wilcoxon rank sum tests, Welch t-tests, or Fisher’s exact tests