Potential drug-drug exposure | Frequency | Events per 100 person-years (Poisson exact 95 %–CI) | Number of patients with at least one DDE (%) | Clinical relevance of a potential interaction (as per prescribing information) |
---|---|---|---|---|
diazepam & omeprazole | 52 | 1.00 (0.74–1.31) | 17 (1.39) | Omeprazole may increase systemic exposure to diazepam [31] |
doxepin & venlafaxine | 54 | 1.03 (0.78–1.35) | 15 (1.23) | not mentioned |
doxepin & paroxetine | 44 | 0.84 (0.61–1.13) | 13 (1.06) | not mentioned |
amitriptyline & omeprazole | 58 | 1.11 (0.84–1.44) | 12 (0.98) | not mentioned |
doxepin & tramadol | 51 | 0.98 (0.73–1.28) | 11 (0.90) | Tramadol may increase the potential of seizures related to tricyclic antidepressants. Serotonin syndrome may occur [32] [unclear if due to CYP interactions] |
amitriptyline & paroxetine | 29 | 0.56 (0.37–0.80) | 9 (0.74) | Patients taking SSRIs should only be treated with amitriptyline with particular caution [33] [reason not given] |
amitriptyline & esomeprazole | 31 | 0.59 (0.40–0.84) | 8 (0.66) | not mentioned |
doxepin & risperidone | 95 | 1.82 (1.47–2.22) | 8 (0.66) | Mutual reinforcement of the central depressant effect [34] |
fluoxetine & omeprazole | 11 | 0.21 (0.11–0.38) | 8 (0.66) | not mentioned |
doxepin & duloxetine | 22 | 0.42 (0.26–0.64) | 7 (0.57) | not mentioned |
… | ||||
Sum | 1393 | 26.72 (25.34–28.16) | 330 |