Table 1 General model inputs

Accuracy of Screening Method

 Sensitivity, Isoelectric Focusing

100.0 %

99.9 %

100.0 %

Exponential

[13]

 Specificity, Isoelectric Focusing

100.0 %

99.9 %

100.0 %

Exponential

[13]

Annual Mortality Risk, Untreated

 Rural

37.0 %

13.3 %

64.8 %

Beta

[5]

 Urban

13.0 %

4.9 %

24.4 %

Beta

[5]

Annual Mortality Risk, Treated

 <= 5 years

7.3 %

4.1 %

10.5 %

Normal

[10]

 6–20 years

1.4 %

1.0 %

1.8 %

Normal

[10]

 21–30 years

1.8 %

1.1 %

2.5 %

Normal

[10]

 >31 years, general population multiplier

4.5

3.0

6.0

Normal

Own calculation

Disability Weight

0.04

0.02

0.06

Beta

[16]

Costs - Screening

 Isoelectric Focusing – fixed cost per sample

$0.044

$0.022

$0.088

Log-normal

[17]

 Isoelectric Focusing – all variable costs

$9.90

$4.45

$18.80

Log-normal

UNHL^a

Annual costs - treatment

 Pneumoccocal Vaccine, year 1 only

$80.64

$40.32

$120.96

Log-normal

AKTH^b

 Mosquito Net, annual for life

$10.00

$5.00

$15.00

Log-normal

[18]

 Proguanil 100 mg, daily for years 1–15

$17.48

$8.74

$26.22

Log-normal

[19]

 Proguanil 200 mg, daily for years >15

$34.97

$17.49

$52.46

Log-normal

[19]

 Folic Acid 5 mg, daily for life

$0.77

$0.39

$1.16

Log-normal

[19]

 Penicillin 125 mg, twice daily for years 1–5

$29.93

$14.97

$44.90

Log-normal

[19]

 Penicillin 250 mg, twice daily for years 6–10

$50.37

$25.19

$75.56

Log-normal

[19]

 Discount Rate

3.0 %

0.0 %

6.0 %

n/A

[11]