Table 3 Factors associated with having a low RDI (RDI < 100 %) among DLBCL patients treated with CHOP21/RCHVP (n = 294)

Age

56 – 65 y

1

1

1

66 to 75y

0.4

[0.2;

0.8]

0.008

0.4

[0.2;

0.8]

0.014

0.4

[0.2;

0.8]

0.010

At least 76y

0.6

[0.2;

1.4]

0.206

0.6

[0.3;

1.5]

0.265

0.6

[0.2;

1.4]

0.246

Gender

Men

1

1

1

Women

1.4

[0.8;

2.6]

0.242

1.4

[0.8;

2.6]

0.233

1.4

[0.8;

2.6]

0.251

Comorbidity

None

1

1

1

At least 1

1.2

[0.6;

2.2]

0.572

1.2

[0.6;

2.2]

0.653

1.2

[0.6;

2.3]

0.583

Performance status

Normal

1

1

1

Degraded

1.5

[0.7;

3.1]

0.310

1.4

[0.7;

3.1]

0.354

1.3

[0.6;

2.9]

0.480

Stage

I/II

1

1

1

III/IV

1.4

[0.8;

2.7]

0.282

1.5

[0.8;

2.8]

0.211

1.5

[0.8;

2.8]

0.235

B symptoms

Absence

1

1

1

Presence

1.4

[0.6;

3.1]

0.472

1.4

[0.6;

3.2]

0.441

1.2

[0.5;

2.9]

0.626

Lactate dehydrogenase

Normal

1

1

1

Elevated

1.2

[0.7;

2.3]

0.491

1.1

[0.6;

2.1]

0.679

1.1

[0.6;

2.0]

0.814

Social deprivation index

Highly fav.

1

1

Favored

0.6

[0.2;

1.8]

0.403

0.7

[0.2;

2.0]

0.508

Intermediate

0.7

[0.3;

1.7]

0.387

0.7

[0.3;

1.8]

0.444

Deprived

1.1

[0.5;

2.7]

0.842

1.1

[0.5;

2.8]

0.815

Highly dep.

1.0

[0.4;

2.6]

0.993

1.0

[0.4;

2.6]

0.935

Distance to the care center (km)

Up to 13 km

1

1

14 – 40 km

1.0

[0.5;

2.1]

0.995

1.2

[0.6;

2.5]

0.687

At least 41 km

1.6

[0.7;

3.3]

0.266

1.5

[0.7;

3.3]

0.323

Hospitalization for toxicity

None

1

At least 1 day

2.8

[1.4;

5.7]

0.006

Type of care center

UH

1

1

1

1

CH

2.3

[1.2;

4.6]

0.019

2.2

[1.0;

4.8]

0.039

2.6

[1.2;

5.6]

0.020

1.9

[0.8;

4.4]

0.120

PH

2.4

[1.2;

4.6]

0.010

2.8

[1.4;

5.6]

0.005

3.3

[1.6;

7.1]

0.002

3.3

[1.5;

7.1]

0.002