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Table 3 Factors associated with having a low RDI (RDI < 100 %) among DLBCL patients treated with CHOP21/RCHVP (n = 294)

From: The care center influences the management of lymphoma patients in a universal health care system: an observational cohort study

   Model 2a Model 2b Model 2c Model 2d
   beta [95 % CI] p-value beta [95 % CI] p-value beta [95 % CI] p-value beta [95 % CI] p-value
Age 56 – 65 y      1     1     1    
66 to 75y      0.4 [0.2; 0.8] 0.008 0.4 [0.2; 0.8] 0.014 0.4 [0.2; 0.8] 0.010
At least 76y      0.6 [0.2; 1.4] 0.206 0.6 [0.3; 1.5] 0.265 0.6 [0.2; 1.4] 0.246
Gender Men      1     1     1    
Women      1.4 [0.8; 2.6] 0.242 1.4 [0.8; 2.6] 0.233 1.4 [0.8; 2.6] 0.251
Comorbidity None      1     1     1    
At least 1      1.2 [0.6; 2.2] 0.572 1.2 [0.6; 2.2] 0.653 1.2 [0.6; 2.3] 0.583
Performance status Normal      1     1     1    
Degraded      1.5 [0.7; 3.1] 0.310 1.4 [0.7; 3.1] 0.354 1.3 [0.6; 2.9] 0.480
Stage I/II      1     1     1    
III/IV      1.4 [0.8; 2.7] 0.282 1.5 [0.8; 2.8] 0.211 1.5 [0.8; 2.8] 0.235
B symptoms Absence      1     1     1    
Presence      1.4 [0.6; 3.1] 0.472 1.4 [0.6; 3.2] 0.441 1.2 [0.5; 2.9] 0.626
Lactate dehydrogenase Normal      1     1     1    
Elevated      1.2 [0.7; 2.3] 0.491 1.1 [0.6; 2.1] 0.679 1.1 [0.6; 2.0] 0.814
Social deprivation index Highly fav.          1     1    
Favored          0.6 [0.2; 1.8] 0.403 0.7 [0.2; 2.0] 0.508
Intermediate          0.7 [0.3; 1.7] 0.387 0.7 [0.3; 1.8] 0.444
Deprived          1.1 [0.5; 2.7] 0.842 1.1 [0.5; 2.8] 0.815
Highly dep.          1.0 [0.4; 2.6] 0.993 1.0 [0.4; 2.6] 0.935
Distance to the care center (km) Up to 13 km          1     1    
14 – 40 km          1.0 [0.5; 2.1] 0.995 1.2 [0.6; 2.5] 0.687
At least 41 km          1.6 [0.7; 3.3] 0.266 1.5 [0.7; 3.3] 0.323
Hospitalization for toxicity None              1    
At least 1 day              2.8 [1.4; 5.7] 0.006
Type of care center UH 1     1     1     1    
CH 2.3 [1.2; 4.6] 0.019 2.2 [1.0; 4.8] 0.039 2.6 [1.2; 5.6] 0.020 1.9 [0.8; 4.4] 0.120
PH 2.4 [1.2; 4.6] 0.010 2.8 [1.4; 5.6] 0.005 3.3 [1.6; 7.1] 0.002 3.3 [1.5; 7.1] 0.002
  1. All the models were adjusted for centre effect using a random intercept which is not presented as its variance in all the models was smaller than 10−8, this may be interpreted as a random intercept variance not statistically different from zero. Global p-values in model 2a type of care center: p < 0.016; in model 2b age: p = 0.029, type of care center: p = 0.013; in model 2c age: p = 0.050, social deprivation index: p = 0.709, distance to the care center: p = 0.456, type of care center: p = 0.005; in model 2d age: p = 0.037, social deprivation index: p = 0.805, distance to the care center: p = 0.612, type of care center: p = 0.009