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Table 2 Relationship between disability (EDSS) and relapse and health care resource utilization among patients with MS

From: Quantifying the relationship between increased disability and health care resource utilization, quality of life, work productivity, health care costs in patients with multiple sclerosis in the US

Parameter, (95 % CI)

Disability (reference group EDSS <3; n = 411)

Relapsed (n = 303) (reference group no relapse; n = 341)

R2, %b

EDSS 3–5 (n = 167)

EDSS > 5 (n = 66)

Consultations in the last 12 monthsa

    

 Neurology

1.3* (1.2–1.5)

1.4* (1.2–1.6)

1.2* (1.1–1.4)

4.42

 Primary care physician

1.0 (0.6–1.5)

0.9 (0.5–1.5)

1.5* (1.1–2.0)

0.71

 MS specialist

1.0 (0.4–2.7)

0.5 (0.1–1.9)

2.4 (0.8–7.3)

1.84

 MS Nurse

6.6* (2.4–18.2)

44.4* (8.0–248.2)

0.8 (0.3–2.1)

7.28

 Internist

1.3 (0.5–3.2)

0.4 (0.1–1.3)

1.6 (0.6–4.2)

1.97

 Emergency room doctor

1.9 (0.6–5.7)

0.8 (0.2–3.6)

15.6* (2.2–109.9)

12.98

 Physiotherapist

3.2* (1.0–10.1)

9.9* (3.2–30.7)

1.5 (0.5–4.4)

5.06

 Ophthalmologist

1.6 (0.9–3.0)

2.3 (1.0–5.4)

4.3* (2.0–8.9)

8.68

 Urologist

4.8* (1.9–12.0)

7.2* (2.2–23.6)

1.8 (0.8–3.9)

7.67

 Gastroenterologist

4.4 (0.6–32.3)

9.7 (0.9–101.9)

7.0* (1.2–41.4)

11.24

 Psychiatrist

1.5 (0.4–5.4)

1.5 (0.3–7.1)

2.8* (1.0–7.7)

2.90

 Other physician

3.9 (0.9–17.6)

6.3 (1.0–40.6)

1.8 (0.7–4.2)

7.69

Hospitalizations in the last 12 monthsa

1.7 (0.8–3.3)

3.3* (1.6–6.8)

7.1* (3.3–15.5)

15.37

  1. EDSS Expanded Disability Status Scale, MS multiple sclerosis
  2. *p < 0.05
  3. aNegative binomial analysis to yield IRRs and 95 % CIs (covariates: patient age, sex and body mass index)
  4. bMcFadden’s R-Squared