Invasive Pneumococcal Disease | All cause pneumonia | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of person-years | Age <18 years | Age 18–64 years | Age ≥65 years | Age <18 years | Age 18–64 years | Age ≥65 years | |||||||||
Age <18 years | Age 18–64 years | Age ≥65 years | Rate per 100 K | Rate ratiosa (95 % CI) | Rate per 100 K | Rate ratiosa (95 % CI) | Rate per 100 K | Rate ratiosa (95 % CI) | Rate per 100 K | Rate ratiosa (95 % CI) | Rate per 100 K | Rate ratiosa (95 % CI) | Rate per 100 K | Rate ratiosa (95 % CI) | |
Risk Group | |||||||||||||||
Healthy | 24,406,759 | 63,445,448 | 5,389,930 | 2.5 | -- | 2.7 | -- | 8.3 | -- | 587 | -- | 458 | -- | 1874 | -- |
At-Risk | 2,002,374 | 13,368,935 | 4,579,505 | 5.9 | 2.4 (2.0–2.9) | 9.3 | 3.4 (3.2–3.7) | 23.0 | 2.8 (2.5–3.1) | 1801 | 3.1 (3.0–3.1) | 1652 | 3.6 (3.6–3.6) | 5662 | 3.0 (3.0–3.0) |
Alcoholism | 4591 | 333,634 | 23,905 | 0.0 | -- | 20.4 | 7.5 (5.9–9.6) | 41.8 | 5.0 (2.7–9.4) | 501 | 0.9 (0.6–1.3) | 2109 | 4.6 (4.5–4.7) | 7400 | 3.9 (3.8–4.1) |
Asthma | 1,252,480 | 2,185,510 | 362,183 | 3.7 | 1.5 (1.1–2.0) | 9.6 | 3.6 (3.1–4.1) | 34.2 | 4.1 (3.4–5.0) | 1718 | 2.9 (2.9–3.0) | 2078 | 4.5 (4.5–4.6) | 8570 | 4.6 (4.5–4.6) |
Chronic heart disease | 136,206 | 3,082,998 | 2,363,798 | 13.9 | 5.7 (3.6–8.9) | 11.5 | 4.3 (3.8–4.8) | 26.6 | 3.2 (2.8–3.6) | 3699 | 6.3 (6.1–6.5) | 2533 | 5.5 (5.5–5.6) | 7100 | 3.8 (3.8–3.8) |
Chronic liver disease | 3759 | 292,697 | 50,540 | 26.6 | 10.8 (1.5–76.7) | 24.6 | 9.1 (7.2–11.5) | 53.4 | 6.4 (4.4–9.5) | 3910 | 6.7 (5.7–7.8) | 3002 | 6.6 (6.4–6.7) | 7742 | 4.1 (4.0–4.3) |
Chronic lung disease | 192,731 | 1,251,143 | 882,061 | 8.3 | 3.4 (2.0–5.5) | 27.0 | 10.0 (8.9–11.2) | 51.1 | 6.2 (5.4–7.0) | 3488 | 5.9 (5.8–6.1) | 4802 | 10.5 (10.4–10.6) | 12,379 | 6.6 (6.6–6.7) |
Chronic use of oral steroids | 22,508 | 275,267 | 65,775 | 13.3 | 5.4 (1.7–16.8) | 8.0 | 3.0 (1.9–4.5) | 15.2 | 1.8 (1.0–3.4) | 1080 | 1.8 (1.6–2.1) | 1164 | 2.5 (2.5–2.6) | 3696 | 2.0 (1.9–2.1) |
Diabetes | 88,848 | 5,721,158 | 2,267,133 | 5.6 | 2.3 (0.9–5.5) | 9.5 | 3.5 (3.2–3.9) | 21.1 | 2.5 (2.2–2.9) | 808 | 1.4 (1.3–1.5) | 1683 | 3.7 (3.6–3.7) | 5266 | 2.8 (2.8–2.8) |
Down’s syndrome | 20,657 | 7649 | 63 | 19.4 | 7.9 (2.9–21.0) | 13.1 | 4.8 (0.7–34.4) | 0.0 | -- | 5514 | 9.4 (8.9–10.0) | 2915 | 6.4 (5.6–7.3) | 6316 | 3.4 (1.3–9.0) |
Neuromuscular/seizure disorders | 193,657 | 507,134 | 104,864 | 11.9 | 4.8 (3.2–7.3) | 12.8 | 4.7 (3.7–6.1) | 38.1 | 4.6 (3.3–6.3) | 2536 | 4.3 (4.2–4.4) | 2254 | 4.9 (4.8–5.0) | 8539 | 4.6 (4.5–4.7) |
Short gestation/low birthweight | 249,576 | 34,580 | 90 | 12.0 | 4.9 (3.4–7.0) | 5.8 | 2.1 (0.5–8.6) | 0.0 | -- | 2768 | 4.7 (4.6–4.8) | 581 | 1.3 (1.1–1.5) | 8864 | 4.7 (2.4–9.5) |
Rheumatoid arthritis/Crohn’s/Lupus | -- | 579,373 | 162,206 | -- | -- | 17.8 | 6.6 (5.4–8.0) | 33.3 | 4.0 (3.0–5.3) | -- | -- | 2131 | 4.7 (4.6–4.7) | 6465 | 3.5 (3.4–3.5) |
Smokers | 5019 | 2,128,945 | 180,504 | 0.0 | -- | 12.5 | 4.6 (4.1–5.3) | 34.9 | 4.2 (3.2–5.5) | 777 | 1.3 (1.0–1.8) | 1858 | 4.1 (4.0–4.1) | 6691 | 3.6 (3.5–3.6) |
High-Risk | 119,692 | 3,062,400 | 1,774,181 | 48.5 | 19.6 (15.0–25.7) | 26.3 | 9.7 (9.0–10.6) | 36.7 | 4.4 (3.9–5.0) | 3757 | 6.4 (6.2–6.6) | 3094 | 6.8 (6.7–6.8) | 7594 | 4.1 (4.0–4.1) |
Chronic renal failure | 17,112 | 356,088 | 344,160 | 64.3 | 26.1 (14.4–47.3) | 47.2 | 17.5 (14.9–20.5) | 50.0 | 6.0 (5.0–7.2) | 4202 | 7.2 (6.7–7.7) | 5566 | 12.2 (12.0–12.3) | 11,873 | 6.3 (6.3–6.4) |
Cochlear implant | 1989 | 2517 | 1144 | 50.3 | 20.4 (2.9–145.0) | 0.0 | -- | 87.4 | 10.5 (1.5–74.8) | 2062 | 3.5 (2.6–4.8) | 1708 | 3.7 (2.8–5.0) | 4544 | 2.4 (1.8–3.2) |
Congenital immunodeficiency | 21,047 | 76,771 | 14,392 | 42.8 | 17.3 (9.0–33.5) | 87.3 | 32.3 (25.3–41.2) | 118.1 | 14.2 (8.8–23.1) | 4409 | 7.5 (7.0–8.0) | 5919 | 12.9 (12.6–13.3) | 14,738 | 7.9 (7.5–8.2) |
Diseases of white blood cells | 15,493 | 149,802 | 46,869 | 122.6 | 49.7 (31.5–78.5) | 62.1 | 23.0 (18.6–28.3) | 110.9 | 13.3 (10.0–17.8) | 6048 | 10.3 (9.7–11.0) | 6797 | 14.8 (14.6–15.1) | 13,262 | 7.1 (6.9–7.3) |
Functional/anatomic asplenia | 19,321 | 109,298 | 42,976 | 119.0 | 48.3 (31.8–73.2) | 93.3 | 34.5 (28.3–42.2) | 116.3 | 14.0 (10.5–18.7) | 8566 | 14.6 (13.9–15.3) | 8721 | 19.0 (18.7–19.4) | 15,976 | 8.5 (8.3–8.7) |
HIV | 1484 | 193,184 | 7306 | 0.0 | -- | 46.6 | 17.2 (13.9–21.3) | 27.4 | 3.3 (0.8–13.2) | 2291 | 3.9 (2.8–5.5) | 2457 | 5.4 (5.2–5.5) | 6461 | 3.4 (3.2–3.8) |
Immuno. conditions/drugs | 63,702 | 2,495,776 | 1,523,021 | 54.9 | 22.3 (15.8–31.3) | 24.4 | 9.0 (8.2–9.9) | 36.4 | 4.4 (3.9–5.0) | 3595 | 6.1 (5.9–6.4) | 3146 | 6.9 (6.8–6.9) | 7248 | 3.9 (3.8–3.9) |