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Table 1 30 top-selling agents on PRISCUS list (Prices in €, Reference year 2009)

From: Potentially inappropriate medication in the elderly in Germany: an economic appraisal of the PRISCUS list

    Aged 65 and above Entire SHI population Ratio aged ≥65 and entire SHI
No. ATC-Code Agent DDD (in Mio.) ≥65 years Prescriptions ≥65 (in Mio.) Sales ≥65 (in Mio. €) Costs per DDD ≥65 Total DDD (in Mio) Total prescriptions (in Mio) Total sales (in Mio. €) Costs per DDD DDD Prescriptions Sales
1 C02CA04 Doxazosin 51.4 0.56 19.5 0.38 € 60.2 0.81 28.1 0.38 € 85.38 % 69.47 % 69.37 %
2 N06AA09 Amitriptyline 45.7 1.13 19.8 0.43 € 94.5 2.28 40.5 0.43 € 48.36 % 49.66 % 48.88 %
3 C07AA07 Sotalol 34.0 0.53 10.2 0.30 € 36.6 0.68 13.0 0.30 € 92.90 % 78.39 % 78.56 %
4 C01AA02 Acetyldigoxin 32.5 0.93 11.7 0.36 € 36.4 1.05 13.3 0.36 € 89.29 % 88.62 % 88.06 %
5 N05CF01 Zopiclona 28.0 1.44 21.5 0.77 € 47.3 2.62 38.7 0.79 € 59.20 % 54.87 % 55.56 %
6 M01AH05 Etoricoxib 25.2 0.50 30.6 1.21 € 51.7 1.07 62.4 1.21 € 48.74 % 46.61 % 49.04 %
7 N06AA12 Doxepin 24.2 0.77 13.1 0.54 € 54.2 1.68 29.1 0.52 € 44.65 % 45.71 % 45.07 %
8 G04BD08 Solifenacin 22.6 0.24 32.5 1.44 € 31.3 0.33 44.8 1.43 € 72.20 % 72.84 % 72.54 %
9 N05CF02 Zolpidema 21.3 1.09 16.3 0.77 € 32.5 1.81 26.7 0.78 € 65.54 % 60.36 % 61.14 %
10 N06BX03 Piracetam 18.3 0.41 8.2 0.45 € 20.6 0.48 9.7 0.45 € 88.83 % 85.85 % 84.86 %
11 C04AD03 Pentoxifylline 15.0 0.35 7.2 0.48 € 17.7 0.57 11.0 0.54 € 84.75 % 61.29 % 65.61 %
12 N05BA08 Bromazepam 14.9 0.66 8.6 0.58 € 21.2 1.04 13.5 0.60 € 70.28 % 63.40 % 63.65 %
13 N06AA06 Trimipramine 14.6 0.49 10.8 0.74 € 31.6 1.12 24.5 0.73 € 46.20 % 43.66 % 44.17 %
14 N05BA01 Diazepam 13.1 0.53 6.0 0.46 € 31.0 1.30 15.3 0.47 € 42.26 % 40.71 % 39.16 %
15 N05CD06 Lormetazepama 12.5 0.38 5.2 0.42 € 15.3 0.51 7.0 0.42 € 81.70 % 74.50 % 74.20 %
16 C02CA08 Terazosin 12.3 0.19 6.6 0.54 € 8.0 0.24 8.2 0.56 € -b - -
17 C02AC01 Clonidine 11.7 0.33 5.9 0.50 € 17.7 0.71 13.5 0.34 € 66.10 % 46.72 % 43.86 %
18 C02LA01 Reserpine and Diuretics 11.3 0.12 4.7 0.42 € 13.1 0.14 5.5 0.42 € 86.26 % 88.82 % 85.45 %
19 C01BC04 Flecainide 9.7 0.22 11.4 1.18 € 14.1 0.34 17.5 1.17 € 68.79 % 64.05 % 65.30 %
20 G04BD04 Oxybutynin 9.3 0.30 8.8 0.95 € 11.3 0.45 15.1 0.95 € 82.30 % 66.64 % 58.14 %
21 M01AC06 Meloxicam 9.3 0.21 3.3 0.35 € 14.8 0.41 6.3 0.38 € 62.84 % 50.66 % 52.12 %
22 N06AB03 Fluoxetine 8.8 0.10 2.9 0.33 € 43.3 0.58 17.3 0.32 € 20.32 % 17.32 % 16.79 %
23 M01AB01 Indometacin 8.7 0.25 4.0 0.46 € 14.2 0.53 8.6 0.48 € 61.27 % 47.36 % 46.63 %
24 C01AA08 Metildigoxin 8.4 0.17 2.7 0.32 € 9.5 0.20 3.0 0.32 € 88.42 % 86.65 % 90.00 %
25 M03BX07 Tetrazepam 8.3 0.57 8.0 0.96 € 22.0 2.08 26.8 1.19 € 37.73 % 27.46 % 29.90 %
26 C04AX21 Naftidrofuryl 7.5 0.34 8.2 1.09 € 9.0 0.43 10.2 1.11 € 83.33 % 78.49 % 80.17 %
27 C08CA05 Nifedipinea 6.5 0.26 3.8 0.58 € 69.7 1.32 22.2 0.29 € 9.33 % 19.70 % 17.11 %
28 M01AB11 Acemetacin 6.4 0.16 4.9 0.77 € 9.8 0.28 8.3 0.80 € 65.31 % 56.34 % 58.76 %
29 M03BX01 Baclofen 6.0 0.26 5.2 0.87 € 17.1 0.66 16.1 0.93 € 35.09 % 39.12 % 32.31 %
30 J01XE01 Nitrofurantoin 5.4 0.26 4.1 0.76 € 8.7 0.43 6.7 0.85 € 62.07 % 59.99 % 61.45 %
Sum Top30    502.9 13.75 305.7   864.40 26.15 562.71   58.18 % 52.59 % 54.33 %
Sum all 83 agents    598.7 16.93 387.8   1,124.00 37.71 1,037.37   53.27 % 44.89 % 37.38 %
  1. aPRISCUS agents which are potentially inappropriate at certain dose or release form
  2. bThe PPR does include the 3,000 top-selling drugs. Several traded products with terazosin as agent are sold less frequently and therefore not included. The published amount of DDD of terazosin is lower than the share of DDD taken by the elderlies. Consequently, calculation is misleading