Table 2 Identifying a history of major IHD or cerebrovascular disease using GP diagnoses as a reference standard
From: Identification of major cardiovascular events in patients with diabetes using primary care data
Drug (at least 1 prescription) | TP | FP | TN | FN | Sens (95 % CI) | Spec (95 % CI) | PPV (95 % CI) | NPV (95 % CI) |
|---|---|---|---|---|---|---|---|---|
IHD/cerebrovascular history | ||||||||
Vitamin K antagonists | 424 | 1029 | 12996 | 2010 | 17 (16–19) | 93 (92–93) | 29 (27–32) | 87 (86–87) |
Platelet aggregation inhibitors | 1696 | 2500 | 11525 | 738 | 70 (68–72) | 82 (82–83) | 40 (39–42) | 94 (94–94) |
Nitrates | 487 | 441 | 13584 | 1947 | 20 (18–22) | 97 (97–97) | 52 (49–56) | 87 (87–88) |
Vitamin K antagonists/Platelet aggregation inhibitors | 2045 | 3441 | 10584 | 389 | 84 (83–85) | 75 (75–76) | 37 (36–39) | 96 (96–97) |
Vitamin K antagonists/Platelet aggregation inhibitors/Nitrates | 2077 | 3519 | 10506 | 357 | 85 (84–87) | 75 (75–76) | 37 (36–38) | 97 (96–97) |
IHD history | ||||||||
Vitamin K antagonists | 354 | 1099 | 13453 | 1553 | 19 (17–20) | 92 (92–93) | 24 (22–27) | 90 (89–90) |
Platelet aggregation inhibitors | 1312 | 2884 | 11668 | 595 | 69 (67–71) | 80 (80–81) | 31 (30–33) | 95 (95–96) |
Nitrates | 466 | 462 | 14090 | 1441 | 24 (23–26) | 97 (97–97) | 50 (47–53) | 91 (90–91) |
Vitamin K antagonists/Platelet aggregation inhibitors | 1603 | 3883 | 10669 | 304 | 84 (82–86) | 73 (73–74) | 29 (28–30) | 97 (97–98) |
Vitamin K antagonists/Platelet aggregation inhibitors/Nitrates | 1907 | 3961 | 10591 | 0 | 100 (100–100) | 73 (72–74) | 32 (31–34) | 100 (100–100) |
Cerebrovascular history | ||||||||
Vitamin K antagonists | 119 | 1334 | 14424 | 582 | 17 (14–20) | 92 (91–92) | 8 (7–10) | 96 (96–96) |
Platelet aggregation inhibitors | 506 | 3690 | 12068 | 195 | 72 (69–75) | 77 (76–77) | 12 (11–13) | 98 (98–99) |
Nitrates | 67 | 861 | 14897 | 634 | 10 (7–12) | 95 (94–95) | 7 (6–9) | 96 (96–96) |
Vitamin K antagonists/Platelet aggregation inhibitors | 604 | 4882 | 10876 | 97 | 86 (83–89) | 69 (68–70) | 11 (10–12) | 99 (99–99) |
Vitamin K antagonists/Platelet aggregation inhibitors/Nitrates | 604 | 4992 | 10766 | 97 | 86 (83–89) | 68 (68–69) | 11 (10–12) | 99 (99–99) |